| URN | urn:agi-llid:2222 |
|---|---|
| Total Entities | 0 |
| Connectivity | 139 |
| Name | Fdft1 |
| Description | farnesyl-diphosphate farnesyltransferase 1 |
| Notes | This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. |
| Ariadne Ontology | Cholesterol-isoprenoid metabolism |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| oxidoreductase activity | |
| transferase activity | |
| transferase activity, transferring alkyl or aryl (other than methyl) groups | |
| squalene synthase activity | |
| farnesyl-diphosphate farnesyltransferase activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| integral to membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| GO Biological Process | metabolic process |
|---|---|
| cellular lipid metabolic process | |
| farnesyl diphosphate metabolic process | |
| isoprenoid biosynthetic process | |
| biosynthetic process | |
| lipid metabolic process | |
| lipid biosynthetic process | |
| steroid metabolic process | |
| steroid biosynthetic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| oxidation-reduction process | |
| small molecule metabolic process |
| Pathway | IGF1/STAT Expression Targets |
|---|---|
| IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| cholesterol biosynthetic pathway | |
| cholesterol biosynthetic pathway |
| Group | Cholesterol-isoprenoid metabolism |
|---|---|
| metabolic process | |
| cellular lipid metabolic process | |
| farnesyl diphosphate metabolic process | |
| isoprenoid biosynthetic process | |
| biosynthetic process | |
| lipid metabolic process | |
| lipid biosynthetic process | |
| steroid metabolic process | |
| steroid biosynthetic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| oxidation-reduction process | |
| small molecule metabolic process | |
| catalytic activity | |
| oxidoreductase activity | |
| transferase activity | |
| transferase activity, transferring alkyl or aryl (other than methyl) groups | |
| squalene synthase activity | |
| farnesyl-diphosphate farnesyltransferase activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| integral to membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| MedScan ID | 2222 |
|---|
| Hugo ID | 3629 |
|---|
| Human chromosome position | 8p23.1-p22 |
|---|
| LocusLink ID | 2222 |
|---|---|
| 14137 | |
| 29580 |
| Alias | SS |
|---|---|
| SQS | |
| DGPT | |
| ERG9 | |
| squalene synthase | |
| squalene synthetase | |
| FPP:FPP farnesyltransferase | |
| presqualene-di-diphosphate synthase | |
| farnesyl-diphosphate farnesyltransferase | |
| farnesyl diphosphate farnesyltransferase | |
| presqualene synthase | |
| presqualene synthases | |
| presqualene synthetase | |
| presqualene-diphosphate synthases | |
| presqualene synthetases | |
| presqualene-diphosphate synthetase | |
| presqualene-diphosphate synthetases | |
| presqualene-diphosphate synthase | |
| farnesyl diphosphate farnesyl transferase I | |
| presqualene-di-diphosphate synthetase | |
| MGC93486 | |
| farnesyl diphosphate farnesyl transferase 1 | |
| farnesyl-diphosphate farnesyltransferase 1 | |
| Farnesyl-diphosphate farnesyltransferase 1 (squalene synthase) | |
| Farnesyl-diphosphate farnesyltransferase 1 (squalene synthetase) | |
| farnesyl-diphosphate farnesyltransferase I | |
| FDFT I | |
| FDFT1 | |
| Squalene synthetase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 184420 |
|---|
| Unigene ID | Hs.593928 |
|---|---|
| Mm.474432 | |
| Rn.154404 | |
| Mm.471602 |
| KEGG ID | hsa:2222 |
|---|---|
| mmu:14137 | |
| rno:29580 |
| Swiss-Prot Accession | P37268 |
|---|---|
| Q6IAX1 | |
| P53798 | |
| Q02769 | |
| Q96GT0 | |
| Q8BPF5 | |
| Q3TS40 | |
| Q9QYT0 | |
| Q8BHH4 |
| EC Number | 2.5.1.21 |
|---|
| GO ID | 0004310 |
|---|---|
| 0016491 | |
| 0051996 | |
| 0044255 | |
| 0006695 | |
| 0045338 | |
| 0008299 | |
| 0044281 | |
| 0006694 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0003824 | |
| 0016740 | |
| 0016765 | |
| 0009058 | |
| 0008203 | |
| 0008610 | |
| 0006629 | |
| 0008152 | |
| 0055114 | |
| 0008202 | |
| 0016126 | |
| 0043231 | |
| 0016020 | |
| 0005792 | |
| 0000287 | |
| 0005515 |
| PIR ID | A45105 |
|---|---|
| A45998 | |
| I38245 | |
| I52090 | |
| S52075 |
| Swiss-Prot ID | FDFT_RAT |
|---|---|
| FDFT_HUMAN | |
| FDFT_MOUSE | |
| Q8BPF5_MOUSE | |
| Q6IAX1_HUMAN |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Endoplasmic reticulum |
| IPI ID | IPI00210233 |
|---|---|
| IPI00020944 | |
| IPI00134836 | |
| IPI00338068 | |
| IPI00798406 | |
| IPI00796512 | |
| IPI00789762 | |
| IPI00797743 | |
| IPI00882422 |
| Mouse chromosome position | 14 3.0 cM |
|---|
| Rat chromosome position | 15p12 |
|---|
| Homologene ID | 3281 |
|---|
| MGI ID | 102706 |
|---|
| RGD ID | 61834 |
|---|
| Primary Cell Localization | Endoplasmic reticulum |
|---|