| URN | urn:agi-llid:1491 |
|---|---|
| Connectivity | 87 |
| Name | Cth |
| Description | cystathionase (cystathionine gamma-lyase) |
| Notes | This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq] |
| Pathway | transsulfuration pathway of homocysteine metabolism |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| lyase activity | |
| pyridoxal phosphate binding | |
| cystathionine beta-lyase activity | |
| cystathionine gamma-lyase activity |
| GO Cellular Component | cytoplasm |
|---|
| GO Biological Process | negative regulation of cell proliferation |
|---|---|
| negative regulation of cell growth | |
| glutathione metabolic process | |
| cellular amino acid metabolic process | |
| hydrogen sulfide biosynthetic process | |
| cysteine metabolic process | |
| homocysteine metabolic process | |
| transsulfuration | |
| cysteine biosynthetic process | |
| cellular amino acid biosynthetic process | |
| protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine | |
| protein homotetramerization |
| Ariadne Ontology | Ser-Gly metabolism |
|---|---|
| Asp-Lys-Thr-Met-Cys metabolsm |
| Group | Ser-Gly metabolism |
|---|---|
| Asp-Lys-Thr-Met-Cys metabolsm | |
| catalytic activity | |
| negative regulation of cell proliferation | |
| negative regulation of cell growth | |
| glutathione metabolic process | |
| cellular amino acid metabolic process | |
| hydrogen sulfide biosynthetic process | |
| cysteine metabolic process | |
| homocysteine metabolic process | |
| transsulfuration | |
| cysteine biosynthetic process | |
| cellular amino acid biosynthetic process | |
| protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine | |
| protein homotetramerization | |
| lyase activity | |
| pyridoxal phosphate binding | |
| cystathionine beta-lyase activity | |
| cystathionine gamma-lyase activity | |
| cytoplasm |
| MedScan ID | 1491 |
|---|
| Hugo ID | 2501 |
|---|
| Human chromosome position | 1p31.1 |
|---|
| LocusLink ID | 1491 |
|---|---|
| 107869 | |
| 24962 |
| Alias | MGC9471 |
|---|---|
| cystathionine gamma-lyase | |
| gamma-cystathionase | |
| homoserine deaminase | |
| cysteine desulfhydrase | |
| homoserine dehydratase | |
| Cys3 | |
| AI314617 | |
| BC019483 | |
| MGC28655 | |
| 0610010I13Rik | |
| OTTMUSP00000038207 | |
| H | |
| PRB-RA | |
| CTL target antigen | |
| probasin-related antigen | |
| 0610010I13 | |
| Cth | |
| cystathionase | |
| cystathionase (cystathionine gamma-lyase) | |
| cystathionase isoform 1 | |
| cystathionase isoform 2 | |
| cystathionase isoform I | |
| cystathionase isoform II | |
| cysteine (sulfite) lyase | |
| cysteine (sulfite) lyases | |
| cysteine lyase | |
| cysteine lyases | |
| homoserine dehydrase | |
| LOC63046 | |
| OTTHUMP00000010945 | |
| OTTHUMP00000010946 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607657 |
|---|---|
| 219500 |
| Mouse chromosome position | 3 |
|---|
| GO ID | 0004121 |
|---|---|
| 0004123 | |
| 0016829 | |
| 0030170 | |
| 0008652 | |
| 0019344 | |
| 0006534 | |
| 0006749 | |
| 0050667 | |
| 0070814 | |
| 0030308 | |
| 0008285 | |
| 0051289 | |
| 0018272 | |
| 0005737 | |
| 0003824 | |
| 0006520 | |
| 0019346 |
| Rat chromosome position | 2q45 |
|---|
| Swiss-Prot Accession | P32929 |
|---|---|
| Q8VCN5 | |
| P18757 | |
| Q9EQS4 | |
| Q53FB3 | |
| Q53Y79 | |
| Q9H4W7 | |
| Q9H4W8 | |
| Q6H324 |
| PIR ID | JC1362 |
|---|---|
| A49864 |
| Unigene ID | Hs.19904 |
|---|---|
| Mm.28301 | |
| Rn.3881 |
| KEGG ID | hsa:1491 |
|---|---|
| mmu:107869 | |
| rno:24962 |
| EC Number | 4.4.1.1 |
|---|
| Swiss-Prot ID | CGL_HUMAN |
|---|---|
| CGL_RAT | |
| CGL_MOUSE | |
| Q53Y79_HUMAN | |
| Q6H324_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00031557 |
|---|---|
| IPI00221301 | |
| IPI00194550 | |
| IPI00122344 |
| Homologene ID | 1432 |
|---|
| RGD ID | 2443 |
|---|
| MGI ID | 1339968 |
|---|