| URN | urn:agi-llid:191 |
|---|---|
| Total Entities | 0 |
| Connectivity | 233 |
| Name | Ahcy |
| Description | adenosylhomocysteinase |
| Notes | S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| GO Molecular Function | adenosylhomocysteinase activity |
|---|---|
| protein self-association | |
| NAD binding | |
| adenyl nucleotide binding | |
| copper ion binding |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| melanosome | |
| nucleus | |
| neuron projection |
| GO Biological Process | chronic inflammatory response to antigenic stimulus |
|---|---|
| small molecule metabolic process | |
| homocysteine biosynthetic process | |
| S-adenosylhomocysteine catabolic process | |
| one-carbon metabolic process | |
| sulfur amino acid metabolic process | |
| response to nutrient | |
| xenobiotic metabolic process | |
| response to hypoxia | |
| circadian sleep-wake cycle | |
| methylation | |
| cellular nitrogen compound metabolic process |
| Pathway | homocysteine metabolic pathway |
|---|
| Group | Asp/Lys/Thr/Met/Cys metabolsm |
|---|---|
| chronic inflammatory response to antigenic stimulus | |
| small molecule metabolic process | |
| homocysteine biosynthetic process | |
| S-adenosylhomocysteine catabolic process | |
| one-carbon metabolic process | |
| sulfur amino acid metabolic process | |
| response to nutrient | |
| xenobiotic metabolic process | |
| response to hypoxia | |
| circadian sleep-wake cycle | |
| methylation | |
| adenosylhomocysteinase activity | |
| cellular nitrogen compound metabolic process | |
| protein self-association | |
| NAD binding | |
| adenyl nucleotide binding | |
| copper ion binding | |
| cytoplasm | |
| cytosol | |
| melanosome | |
| nucleus | |
| neuron projection |
| LocusLink ID | 191 |
|---|---|
| 269378 | |
| 29443 |
| Cell Localization | Cytoplasm |
|---|---|
| Melanosome |
| GO ID | 0004013 |
|---|---|
| 0034641 | |
| 0032259 | |
| 0006730 | |
| 0044281 | |
| 0000096 | |
| 0006805 | |
| 0005737 | |
| 0005829 | |
| 0042470 | |
| 0051287 | |
| 0030554 | |
| 0005507 | |
| 0043621 | |
| 0019510 | |
| 0002439 | |
| 0042745 | |
| 0071268 | |
| 0007584 | |
| 0043005 | |
| 0005634 | |
| 0001666 | |
| 0016787 | |
| 0008152 | |
| 0019717 |
| Alias | SAHH |
|---|---|
| adoHcyase | |
| adenosylhomocysteinase | |
| S-adenosylhomocysteine hydrolase | |
| S-adenosyl-L-homocysteine hydrolase | |
| CuBP | |
| AA987153 | |
| AL024110 | |
| RP23-192A6.3 | |
| liver copper-binding protein | |
| MGC118063 | |
| OTTMUSP00000017088 | |
| MGC19228 | |
| OTTHUMP00000030684 | |
| AHCY | |
| MGC102079 |
| Mouse chromosome position | 2 76.94 cM |
|---|---|
| 2 89.0 cM |
| OMIM ID | 180960 |
|---|---|
| 613752 |
| Rat chromosome position | 3q42 |
|---|
| Hugo ID | 343 |
|---|
| Human chromosome position | 20q11.22 |
|---|---|
| 20cen-q13.1 |
| Swiss-Prot Accession | P23526 |
|---|---|
| P50247 | |
| Q3TF14 | |
| Q5M9P0 | |
| P10760 | |
| Q91WF1 | |
| A8K307 | |
| B3KUN3 | |
| E1P5P2 | |
| F5H737 | |
| Q96A36 | |
| Q1RMG2 | |
| Q3U4D1 | |
| Q3U5U5 | |
| Q8BPI7 | |
| Q6P743 |
| PIR ID | A26583 |
|---|---|
| A43629 |
| Unigene ID | Hs.388004 |
|---|---|
| Mm.330692 | |
| Mm.371964 | |
| Rn.5878 |
| KEGG ID | hsa:191 |
|---|---|
| mmu:269378 | |
| rno:29443 |
| Swiss-Prot ID | SAHH_MOUSE |
|---|---|
| SAHH_RAT | |
| SAHH_HUMAN | |
| Q5M9P0_MOUSE | |
| B3KUN3_HUMAN | |
| Q3TF14_MOUSE | |
| A8K307_HUMAN |
| EC Number | 3.3.1.1 |
|---|
| Ensembl ID | ENSG00000101444 |
|---|---|
| ENSP00000217426 | |
| ENST00000217426 | |
| ENSP00000442820 | |
| ENST00000538132 | |
| ENSMUSG00000027597 | |
| ENSMUSP00000061851 | |
| ENSMUST00000054607 | |
| ENSRNOG00000017777 | |
| ENSRNOP00000024310 | |
| ENSRNOT00000024310 |
| Homologene ID | 554 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 87968 |
|---|
| RGD ID | 69260 |
|---|
| MedScan ID | 191 |
|---|
| IPI ID | IPI00476295 |
|---|---|
| IPI00230440 | |
| IPI00012007 | |
| IPI00750092 |