| URN | urn:agi-llid:635 |
|---|---|
| Total Entities | 0 |
| Connectivity | 170 |
| Name | Bhmt |
| Description | betaine--homocysteine S-methyltransferase |
| Notes | This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq] |
| GO Molecular Function | methyltransferase activity |
|---|---|
| homocysteine S-methyltransferase activity | |
| betaine-homocysteine S-methyltransferase activity | |
| protein complex binding | |
| zinc ion binding |
| GO Cellular Component | protein complex |
|---|---|
| cytoplasm | |
| cytosol |
| GO Biological Process | small molecule metabolic process |
|---|---|
| methionine biosynthetic process | |
| sulfur amino acid metabolic process | |
| regulation of homocysteine metabolic process | |
| response to organonitrogen compound | |
| methylation | |
| cellular nitrogen compound metabolic process | |
| amino-acid betaine catabolic process | |
| protein methylation |
| Pathway | homocysteine metabolic pathway |
|---|
| Group | Asp/Lys/Thr/Met/Cys metabolsm |
|---|---|
| Ser/Gly metabolism | |
| small molecule metabolic process | |
| methionine biosynthetic process | |
| sulfur amino acid metabolic process | |
| regulation of homocysteine metabolic process | |
| response to organonitrogen compound | |
| methylation | |
| methyltransferase activity | |
| homocysteine S-methyltransferase activity | |
| betaine-homocysteine S-methyltransferase activity | |
| cellular nitrogen compound metabolic process | |
| amino-acid betaine catabolic process | |
| protein methylation | |
| protein complex binding | |
| zinc ion binding | |
| protein complex | |
| cytoplasm | |
| cytosol | |
| Secreted proteins |
| LocusLink ID | 635 |
|---|---|
| 12116 | |
| 81508 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0047150 |
|---|---|
| 0008898 | |
| 0032403 | |
| 0008270 | |
| 0006579 | |
| 0034641 | |
| 0009086 | |
| 0006479 | |
| 0050666 | |
| 0044281 | |
| 0000096 | |
| 0005737 | |
| 0005829 | |
| 0043234 | |
| 0008168 | |
| 0032259 | |
| 0010243 | |
| 0046872 | |
| 0016740 |
| Alias | BHMT1 |
|---|---|
| HEL-S-61p | |
| betaine--homocysteine S-methyltransferase 1 | |
| epididymis secretory sperm binding protein Li 61p | |
| betaine-homocysteine methyltransferase | |
| LOC328308 | |
| MGC117976 | |
| MGC46866 | |
| LOC83323 | |
| BHMT | |
| LOC116122 | |
| Betaine-homocysteine S-methyltransferase | |
| OTTMUSP00000029215 | |
| betaine homocysteine methyltransferase |
| Mouse chromosome position | 13 |
|---|
| OMIM ID | 602888 |
|---|
| Rat chromosome position | 2q12 |
|---|
| Hugo ID | 1047 |
|---|
| Human chromosome position | 5q14.1 |
|---|---|
| 5q13.1-q15 |
| Swiss-Prot Accession | Q93088 |
|---|---|
| E5RJH0 | |
| O35490 | |
| O09171 | |
| Q6AZ06 | |
| Q3UEM1 | |
| Q3UL72 | |
| Q561N0 | |
| Q9UNI9 | |
| Q6EI07 | |
| Q3UEP0 |
| Unigene ID | Hs.80756 |
|---|---|
| Mm.329582 | |
| Mm.423099 | |
| Rn.11406 |
| KEGG ID | hsa:635 |
|---|---|
| mmu:12116 | |
| rno:81508 |
| Swiss-Prot ID | BHMT1_RAT |
|---|---|
| BHMT1_MOUSE | |
| BHMT1_HUMAN |
| EC Number | 2.1.1.5 |
|---|
| Ensembl ID | ENSG00000145692 |
|---|---|
| ENSP00000274353 | |
| ENST00000274353 | |
| ENSMUSG00000074768 | |
| ENSMUSP00000096912 | |
| ENSMUST00000099309 | |
| ENSRNOG00000011200 | |
| ENSRNOP00000015336 | |
| ENSRNOT00000015336 |
| Homologene ID | 1295 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1339972 |
|---|
| RGD ID | 621496 |
|---|
| MedScan ID | 635 |
|---|
| IPI ID | IPI00332027 |
|---|---|
| IPI00130950 | |
| IPI00004101 | |
| IPI00910055 | |
| IPI00652371 |