| URN | urn:agi-llid:191 |
|---|---|
| Connectivity | 66 |
| Name | Ahcy |
| Description | adenosylhomocysteinase |
| Notes | S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | methionine cycle/metabolic pathway |
|---|---|
| homocysteine metabolic pathway | |
| methionine cycle-metabolic pathway |
| GO Molecular Function | hydrolase activity |
|---|---|
| NAD or NADH binding | |
| protein self-association | |
| adenyl nucleotide binding | |
| copper ion binding | |
| adenosylhomocysteinase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| melanosome | |
| nucleus | |
| synaptosome |
| GO Biological Process | metabolic process |
|---|---|
| one-carbon metabolic process | |
| S-adenosylhomocysteine catabolic process | |
| chronic inflammatory response to antigenic stimulus | |
| response to nutrient | |
| response to hypoxia | |
| circadian sleep-wake cycle |
| Ariadne Ontology | Asp-Lys-Thr-Met-Cys metabolsm |
|---|
| Group | Asp-Lys-Thr-Met-Cys metabolsm |
|---|---|
| metabolic process | |
| one-carbon metabolic process | |
| S-adenosylhomocysteine catabolic process | |
| chronic inflammatory response to antigenic stimulus | |
| response to nutrient | |
| response to hypoxia | |
| circadian sleep-wake cycle | |
| hydrolase activity | |
| NAD or NADH binding | |
| protein self-association | |
| adenyl nucleotide binding | |
| copper ion binding | |
| adenosylhomocysteinase activity | |
| cytoplasm | |
| cytosol | |
| melanosome | |
| nucleus | |
| synaptosome |
| MedScan ID | 191 |
|---|
| Hugo ID | 343 |
|---|
| Human chromosome position | 20cen-q13.1 |
|---|
| LocusLink ID | 191 |
|---|---|
| 269378 | |
| 29443 |
| Alias | SAHH |
|---|---|
| adenosylhomocysteinase | |
| adoHcyase | |
| S-adenosylhomocysteine hydrolase | |
| S-adenosyl-L-homocysteine hydrolase | |
| CuBP | |
| AA987153 | |
| AL024110 | |
| MGC19228 | |
| MGC102079 | |
| MGC118063 | |
| RP23-192A6.3 | |
| OTTMUSP00000017088 | |
| liver copper-binding protein | |
| AHCY | |
| OTTHUMP00000030684 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 180960 |
|---|
| Mouse chromosome position | 2 89.0 cM |
|---|
| GO ID | 0004013 |
|---|---|
| 0016787 | |
| 0008152 | |
| 0006730 | |
| 0005737 | |
| 0042470 | |
| 0051287 | |
| 0030554 | |
| 0005507 | |
| 0043621 | |
| 0019510 | |
| 0002439 | |
| 0042745 | |
| 0007584 | |
| 0005829 | |
| 0005634 | |
| 0019717 | |
| 0001666 |
| Rat chromosome position | 3q42 |
|---|
| Swiss-Prot Accession | B3KUN3 |
|---|---|
| P23526 | |
| Q1RMG2 | |
| P50247 | |
| Q3TF14 | |
| Q5M9P0 | |
| Q3U4D1 | |
| Q3U5U5 | |
| Q8BPI7 | |
| P10760 | |
| Q6P743 | |
| Q91WF1 | |
| A8K307 | |
| Q96A36 |
| PIR ID | A26583 |
|---|---|
| A43629 |
| Unigene ID | Hs.388004 |
|---|---|
| Mm.330692 | |
| Mm.371964 | |
| Rn.5878 |
| KEGG ID | hsa:191 |
|---|---|
| mmu:269378 | |
| rno:29443 |
| EC Number | 3.3.1.1 |
|---|
| Swiss-Prot ID | SAHH_RAT |
|---|---|
| SAHH_MOUSE | |
| SAHH_HUMAN | |
| Q5M9P0_MOUSE | |
| B3KUN3_HUMAN | |
| Q3TF14_MOUSE | |
| A8K307_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Melanosome |
| IPI ID | IPI00476295 |
|---|---|
| IPI00230440 | |
| IPI00012007 | |
| IPI00750092 |
| Homologene ID | 554 |
|---|
| RGD ID | 69260 |
|---|
| MGI ID | 87968 |
|---|