Elsevier Inc. S-adenosylhomocysteine <--> homocysteine 5-methyl-THF ---> THF Cbl Mtr remethylation pathway of homocysteine metabolism - cobalamin dependent 5-methyl-THF homocysteine adenosine S-adenosylmethionine Bhmt Mtrr Mthfr Ahcy transsulfuration pathway of homocysteine metabolism methionine dimethylglycine THF dimethylglycine ---| Bhmt S-adenosylmethionine ---| remethylation pathway of homocysteine metabolism - cobalamin dependent S-adenosylmethionine --+> transsulfuration pathway of homocysteine metabolism betaine S-adenosylhomocysteine homocysteine ---> cysteine, donwstream metabolites S-adenosylhomocysteine ---> adenosine betaine ---> dimethylglycine Mtrr ---> Mtr cysteine, donwstream metabolites folate cycle metabolic pathway folate mediated one-carbon metabolic pathway methionine cycle/metabolic pathway remethylation pathway of homocysteine metabolism - cobalamin independent, betaine dependent S-adenosylmethionine ---> S-adenosylhomocysteine homocysteine ---> methionine