| URN | urn:agi-llid:5503 |
|---|---|
| Total Entities | 0 |
| Connectivity | 469 |
| Name | Ppp1r1b |
| Description | protein phosphatase 1, regulatory (inhibitor) subunit 1B |
| Notes | This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| GO Molecular Function | protein kinase inhibitor activity |
|---|---|
| protein phosphatase inhibitor activity | |
| protein serine-threonine phosphatase inhibitor activity | |
| protein phosphatase type 1 regulator activity | |
| receptor binding | |
| D1 dopamine receptor binding | |
| D2 dopamine receptor binding | |
| D3 dopamine receptor binding | |
| D4 dopamine receptor binding | |
| D5 dopamine receptor binding |
| GO Cellular Component | intracellular |
|---|---|
| cytoplasm | |
| cytosol | |
| nucleus | |
| neuronal cell body |
| GO Biological Process | negative regulation of female receptivity |
|---|---|
| visual learning | |
| signal transduction | |
| intracellular signal transduction | |
| response to amphetamine | |
| negative regulation of protein kinase activity | |
| negative regulation of catalytic activity | |
| transcription, DNA-templated |
| Pathway | Induction of Apoptosis and Immediate Early Gene Activation in Hippocampal Neurons Following Seizures |
|---|---|
| dopamine signaling pathway | |
| dopamine signaling pathway |
| Group | Phosphatases |
|---|---|
| negative regulation of female receptivity | |
| visual learning | |
| signal transduction | |
| intracellular signal transduction | |
| response to amphetamine | |
| negative regulation of protein kinase activity | |
| protein kinase inhibitor activity | |
| negative regulation of catalytic activity | |
| protein phosphatase inhibitor activity | |
| protein serine-threonine phosphatase inhibitor activity | |
| protein phosphatase type 1 regulator activity | |
| transcription, DNA-templated | |
| receptor binding | |
| D1 dopamine receptor binding | |
| D2 dopamine receptor binding | |
| D3 dopamine receptor binding | |
| D4 dopamine receptor binding | |
| D5 dopamine receptor binding | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| neuronal cell body | |
| Biofluids assayable substances |
| LocusLink ID | 5503 |
|---|---|
| 84152 | |
| 19049 | |
| 360616 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0004860 |
|---|---|
| 0004864 | |
| 0008599 | |
| 0005102 | |
| 0035556 | |
| 0007621 | |
| 0006469 | |
| 0001975 | |
| 0007165 | |
| 0006351 | |
| 0008542 | |
| 0005737 | |
| 0005829 | |
| 0043025 | |
| 0005634 | |
| 0031748 | |
| 0031749 | |
| 0031750 | |
| 0031751 | |
| 0031752 | |
| 0004865 | |
| 0043086 | |
| 0005622 |
| Alias | DARPP32 |
|---|---|
| DARPP-32 | |
| protein phosphatase 1 regulatory subunit 1B | |
| dopamine and cAMP-regulated neuronal phosphoprotein 32 | |
| AU040756 | |
| RP23-355L10.2 | |
| dopamine- and cAMP-regulated neuronal phosphoprotein | |
| neuronal phosphoprotein DARPP-32 | |
| dopamine- and cAMP-regulated phosphoprotein DARPP-32 | |
| dopamine and cAMP-regulated phosphoprotein 32 | |
| Ppp1r1b | |
| protein phosphatase 1, regulatory (inhibitor) subunit 1B | |
| protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP | |
| protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32) | |
| OTTMUSP00000044846 | |
| dopamine and adenosine 3',5' monophosphate regulated phosphoprotein 32,000 | |
| OTTMUSP00000044847 | |
| dopamine and cyclic amp regulated phosphoprotein 32 | |
| dopamine and cyclic amp regulated phosphoprotein 32,000 | |
| phosphoprotein DARPP 32 | |
| OTTMUSP00000002442 | |
| dopamine and cAMP regulated phosphoprotein | |
| FLJ20940 | |
| LOC192855 | |
| MGC18770 | |
| OTTHUMP00000164275 | |
| OTTHUMP00000164276 |
| Mouse chromosome position | 11 |
|---|
| OMIM ID | 604399 |
|---|
| Rat chromosome position | 10q31 |
|---|
| Hugo ID | 9287 |
|---|
| Human chromosome position | 17q12 |
|---|
| Swiss-Prot Accession | Q9UD71 |
|---|---|
| B3KVQ9 | |
| Q60829 | |
| Q6J4I0 | |
| A2A564 | |
| Q3URF2 | |
| Q6DV86 | |
| Q91XB5 | |
| Q547V9 | |
| Q547W0 | |
| Q9H7G1 |
| Unigene ID | Hs.286192 |
|---|---|
| Mm.45372 | |
| Rn.70366 |
| KEGG ID | hsa:84152 |
|---|---|
| mmu:19049 | |
| rno:360616 |
| Swiss-Prot ID | PPR1B_RAT |
|---|---|
| PPR1B_MOUSE | |
| PPR1B_HUMAN |
| EC Number | 3.1.3.16 |
|---|
| Ensembl ID | ENSG00000131771 |
|---|---|
| ENSP00000377808 | |
| ENST00000394265 | |
| ENSP00000254079 | |
| ENST00000254079 | |
| ENSP00000377810 | |
| ENST00000394267 | |
| ENSMUSG00000061718 | |
| ENSMUSP00000077760 | |
| ENSMUST00000078694 | |
| ENSRNOG00000028404 | |
| ENSRNOP00000034614 | |
| ENSRNOT00000037752 |
| Homologene ID | 12972 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 94860 |
|---|
| RGD ID | 621859 |
|---|
| MedScan ID | 5503 |
|---|