Protein Gnai2

URN	urn:agi-llid:2771
Total Entities	0
Connectivity	554
Name	Gnai2
Description	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Notes	The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GO Molecular Function	GTPase activity
	signal transducer activity
	G-protein beta-gamma-subunit complex binding
	G-protein coupled receptor binding
	nucleotide binding
	GTP binding
	guanyl nucleotide binding
	metal ion binding

GO Cellular Component	membrane
	membrane raft
	heterotrimeric G-protein complex
	extrinsic component of cytoplasmic side of plasma membrane
	centrosome
	midbody
	plasma membrane
	cytoplasm
	cytosol
	cytoskeleton
	nucleus

GO Biological Process	cell proliferation
	negative regulation of adenylate cyclase activity
	activation of MAPKK activity
	GTP catabolic process
	blood coagulation
	platelet activation
	regulation of heart contraction
	cell division
	cell cycle
	signal transduction
	intracellular signal transduction
	G-protein coupled receptor signaling pathway
	gamma-aminobutyric acid signaling pathway
	G-protein coupled glutamate receptor signaling pathway
	G-protein coupled acetylcholine receptor signaling pathway
	adenosine receptor signaling pathway
	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
	synaptic transmission
	negative regulation of synaptic transmission
	positive regulation of cell proliferation
	regulation of calcium ion transport
	response to nutrient

Pathway	Effect of NO on Vasodilation and Triptans on Vasoconstriction in Familial Hemiplegic Migraine
	Melanoma Overview
	Contraction due Vasospasm
	ADORA3 -> mast cell degranulation
	GRM2-4/6-8 (presynaptic) -> glutamate release attenuation
	OPRD/OPRM -> ion channels
	P2RY2/12/13/14 -> N-type calcium channel
	BDKRB1/2 -> prostaglandin generation
	BDKRB1/2 -> interleukins production
	BDKRB1/2 -> vasodilation
	BDKRB1/2 -> ion channels
	CRH -> synthesis of corticosteroids
	HTR1 -> vascular motility
	HTR1 -> IL6 production
	HTR1 -> membrane transport
	CNR1/2 -> membrane transport
	CNR1/2 -> vascular motility
	CNR1/2 -> IL1B/2/4/6/10 production
	CHRM1/2/3/5 -> ion channels
	CHRM1/2/3 -> vascular motility
	CHRM1 -> IL2 production
	NPY1R -> CRH/POMC production
	GALR1/2/3 -> neurotransmitter metabolism
	GALR1/2/3 -> POMC/NPY production
	Regulation of potassium flux
	Summarized nociception-related expression targets
	Summarized vascular motility pathway
	Regulation of calcium flux
	CholinergicRm -> CREB/ELK-SRF signaling
	CannabinoidR -> AP-1/EGR signaling
	NeuropeptideYR -> ATF/CREB signaling
	SerotoninR1 -> FOS signaling
	IL8R -> CREB/EGR signaling
	NPY Expression Targets
	Dronabinol/Anandamide Expression Targets
	Acetylcholine Expression Targets
	CXCL1 Expression Targets
	CXCL2 Expression Targets
	CXCL3 Expression Targets
	CXCL5 Expression Targets
	CXCL6 Expression Targets
	dopamine signaling pathway

Group	Gi/o
	cell proliferation
	negative regulation of adenylate cyclase activity
	activation of MAPKK activity
	GTP catabolic process
	GTPase activity
	blood coagulation
	platelet activation
	regulation of heart contraction
	cell division
	cell cycle
	signal transduction
	signal transducer activity
	intracellular signal transduction
	G-protein coupled receptor signaling pathway
	gamma-aminobutyric acid signaling pathway
	G-protein coupled glutamate receptor signaling pathway
	G-protein coupled acetylcholine receptor signaling pathway
	adenosine receptor signaling pathway
	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
	synaptic transmission
	negative regulation of synaptic transmission
	positive regulation of cell proliferation
	regulation of calcium ion transport
	response to nutrient
	G-protein beta-gamma-subunit complex binding
	G-protein coupled receptor binding
	nucleotide binding
	GTP binding
	guanyl nucleotide binding
	metal ion binding
	membrane
	membrane raft
	heterotrimeric G-protein complex
	extrinsic component of cytoplasmic side of plasma membrane
	centrosome
	midbody
	plasma membrane
	cytoplasm
	cytosol
	cytoskeleton
	nucleus

Cell Localization	Cytoplasm
	Cytoskeleton
	Microtubule organizing center
	Centrosome
	Cell membrane

Alias	GIP
	GNAI2B
	H_LUCA15.1
	H_LUCA16.1
	guanine nucleotide-binding protein G(i) subunit alpha-2
	adenylate cyclase-inhibiting G alpha protein
	GTP-binding regulatory protein Gi alpha-2 chain
	guanine nucleotide-binding protein G(i), alpha-2 subunit
	Gia
	C76432
	Gnai-2
	Galphai2
	guanine nucleotide binding protein, alpha inhibiting 2
	G alpha inhibitory type 2 (a)
	G alpha inhibitory type 2 (b)
	GTP-binding protein (G-alpha-i2)
	guanine nucleotide binding protein (G protein), alpha inhibiting 2
	GTP-binding regulatory Gi alpha-2 chain
	OTTHUMP00000211067
	guanine nucleotide binding protein, alpha inhibiting II
	GTP-binding regulatory protein Gi alpha-2 chain (adenylate
	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
	Guanine nucleotide-binding protein (G protein), alpha-inhibiting
	WUGSC:H_LUCA16.1
	WUGSC:H_LUCA15.1
	OTTHUMP00000211066
	G protein alpha inhibiting activity polypeptide 2
	Gnai2
	Adenylate cyclase-inhibiting G alpha protein 2
	Adenylate cyclase-inhibiting G alpha protein II
	G alpha i2
	g alpha inhibitory type 2
	OTTHUMP00000211070
	G protein alpha inhibiting activity polypeptide II
	G(i), alpha II
	G(i), alpha-2
	G(i2)
	GBI2
	GBI2_HUMAN

Mouse chromosome position	9 58.43 cM

OMIM ID	139360
	192605

Rat chromosome position	8q32

Hugo ID	4385

Human chromosome position	3p21.31

Homologene ID	55539

MGI ID	95772

RGD ID	620243

MedScan ID	2771