Protein Gnao1

URN	urn:agi-llid:2775
Total Entities	0
Connectivity	436
Name	Gnao1
Description	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Notes	guanine nucleotide binding protein involved in mediating signal transduction between membrane receptors and intracellular second messengers [RGD, Feb 2006]

GO Molecular Function	GTPase activity
	signal transducer activity
	protein complex binding
	GTPase activating protein binding
	G-protein beta-gamma-subunit complex binding
	G-protein coupled serotonin receptor binding
	mu-type opioid receptor binding
	corticotropin-releasing hormone receptor 1 binding
	nucleotide binding
	GDP binding
	GTP binding
	guanyl nucleotide binding
	metal ion binding

GO Cellular Component	membrane
	heterotrimeric G-protein complex
	extrinsic component of cytoplasmic side of plasma membrane
	protein complex
	intracellular
	plasma membrane
	neuron projection

GO Biological Process	cellular process
	GTP catabolic process
	positive regulation of GTPase activity
	muscle contraction
	regulation of heart contraction
	forebrain development
	neuron projection development
	aging
	signal transduction
	G-protein coupled receptor signaling pathway
	dopamine receptor signaling pathway
	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
	negative regulation of calcium ion transport
	response to drug
	response to hydrogen peroxide
	response to cytokine
	response to organonitrogen compound
	response to organic cyclic compound
	response to morphine
	locomotory behavior

Pathway	Effect of NO on Vasodilation and Triptans on Vasoconstriction in Familial Hemiplegic Migraine
	Congenital Hypothyroidism Due to Thyroid-Stimulating Hormone Resistance
	Thyroid Dysfunction in Graves Disease
	Primary Overt Hypothyroidism Overview
	Contraction due Vasospasm
	GRM2-4/6-8 (presynaptic) -> glutamate release attenuation
	P2RY2/12/13/14 -> N-type calcium channel
	CRH -> synthesis of corticosteroids
	HTR1 -> vascular motility
	HTR1 -> IL6 production
	HTR1 -> membrane transport
	Summarized nociception-related expression targets
	Summarized vascular motility pathway
	Regulation of calcium flux
	SerotoninR1 -> FOS signaling
	dopamine signaling pathway

Group	Gi/o
	cellular process
	GTP catabolic process
	GTPase activity
	positive regulation of GTPase activity
	muscle contraction
	regulation of heart contraction
	forebrain development
	neuron projection development
	aging
	signal transduction
	signal transducer activity
	G-protein coupled receptor signaling pathway
	dopamine receptor signaling pathway
	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
	negative regulation of calcium ion transport
	response to drug
	response to hydrogen peroxide
	response to cytokine
	response to organonitrogen compound
	response to organic cyclic compound
	response to morphine
	locomotory behavior
	protein complex binding
	GTPase activating protein binding
	G-protein beta-gamma-subunit complex binding
	G-protein coupled serotonin receptor binding
	mu-type opioid receptor binding
	corticotropin-releasing hormone receptor 1 binding
	nucleotide binding
	GDP binding
	GTP binding
	guanyl nucleotide binding
	metal ion binding
	membrane
	heterotrimeric G-protein complex
	extrinsic component of cytoplasmic side of plasma membrane
	protein complex
	intracellular
	plasma membrane
	neuron projection
	Genes with Mutations Associated with Breast Cancer
	Genes with Mutations Associated with Ovarian Cancer
	Secreted proteins

Cell Localization	Cytoplasm

Alias	GNAO
	EIEE17
	G-ALPHA-o
	guanine nucleotide-binding protein G(o) subunit alpha
	alphaO
	Galphao
	AW050213
	Go alpha
	GTP-binding protein alpha-o subunit
	RATBPGTPC
	GTP-binding protein alpha o
	guanine nucleotide binding protein, alpha O polypeptide 1
	Guanine nucleotide-binding protein G(O), alpha subunit II
	Goalpha
	Go-alpha
	guanine nucleotide binding (G), alpha activating activity polypeptide O
	guanine nucleotide binding protein, alpha activating polypeptide O
	guanine nucleotide binding protein, alpha o
	Guanine nucleotide-binding protein G(O), alpha subunit 2
	alpha-subunit of Go
	Gnao1
	DKFZp686O0962
	G protein alpha activating activity polypeptide O
	G(alphao)
	G(O), alpha 2
	G(O), alpha subunit 2
	G(O), alpha subunit II
	G(o1)
	Gnao I
	G(O), alpha II
	OTTMUSP00000046458

Mouse chromosome position	8 45.94 cM

OMIM ID	139311
	615473

Rat chromosome position	19p12

Hugo ID	4389

Human chromosome position	16q13

Homologene ID	39203

MGI ID	95775

RGD ID	628732

MedScan ID	2775