Protein Gnal

URN	urn:agi-llid:2774
Total Entities	0
Connectivity	90
Name	Gnal
Description	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
Notes	This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GO Molecular Function	adenylate cyclase activity
	GTPase activity
	signal transducer activity
	G-protein beta-gamma-subunit complex binding
	toxin receptor binding
	G-protein coupled receptor binding
	nucleotide binding
	GTP binding
	guanyl nucleotide binding
	metal ion binding

GO Cellular Component	heterotrimeric G-protein complex
	extrinsic component of cytoplasmic side of plasma membrane
	plasma membrane

GO Biological Process	cAMP biosynthetic process
	activation of adenylate cyclase activity
	GTP catabolic process
	sensory perception of smell
	signal transduction
	G-protein coupled receptor signaling pathway
	adenylate cyclase-activating dopamine receptor signaling pathway
	adenylate cyclase-activating G-protein coupled receptor signaling pathway
	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
	synaptic transmission
	response to caffeine
	response to amphetamine

Pathway	dopamine signaling pathway

Group	Gs
	cAMP biosynthetic process
	adenylate cyclase activity
	activation of adenylate cyclase activity
	GTP catabolic process
	GTPase activity
	sensory perception of smell
	signal transduction
	signal transducer activity
	G-protein coupled receptor signaling pathway
	adenylate cyclase-activating dopamine receptor signaling pathway
	adenylate cyclase-activating G-protein coupled receptor signaling pathway
	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
	synaptic transmission
	response to caffeine
	response to amphetamine
	G-protein beta-gamma-subunit complex binding
	toxin receptor binding
	G-protein coupled receptor binding
	nucleotide binding
	GTP binding
	guanyl nucleotide binding
	metal ion binding
	heterotrimeric G-protein complex
	extrinsic component of cytoplasmic side of plasma membrane
	plasma membrane

Cell Localization	Cytoplasm

Alias	DYT25
	guanine nucleotide-binding protein G(olf) subunit alpha
	adenylate cyclase-stimulating G alpha protein, olfactory type
	guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide, olfactory type
	Golf
	Gna10
	Galphaolf
	2610011C15Rik
	9630020G10Rik
	G alpha 10
	guanine nucleotide binding protein, alpha 10
	Olf
	RGD1305940
	Olf-alpha protein (olfactory neuron-specific G protein)
	guanine nucleotide-binding protein G(olf), alpha subunit
	RIKEN cDNA 9630020G10 gene
	MGC90869
	2610011C15
	guanine nucleotide binding protein, alpha stimulating, olfactory type
	guanine nucleotide-binding protein, alpha-subunit, olfactory type
	olfactory neuron-specific G
	Olf-alpha
	G(a)10
	RIKEN cDNA 2610011C15 gene
	Golf protein
	G[a]10
	9630020G10
	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
	Adenylate cyclase-stimulation G alpha protein, olfactory type
	AI843190
	G alpha protein, olfactory type
	G protein, alpha stimulating activity polypeptide, olfactory type
	G protein, alpha stimulation activity polypeptide, olfactory type
	G(olf), alpha subunit
	GNAL
	G alpha olf

Mouse chromosome position	18 39.85 cM

OMIM ID	139312
	615073

Rat chromosome position	18q12.1-q12.2

Hugo ID	4388

Human chromosome position	18p11.22-p11.21

PIR ID	I53271
	A33833

Swiss-Prot ID	GNAL_HUMAN
	GNAL_MOUSE

Homologene ID	68222

MGI ID	95774

RGD ID	2715

MedScan ID	2774