| URN | urn:agi-llid:5049 |
|---|---|
| Connectivity | 5 |
| Name | Pafah1b2 |
| Description | platelet-activating factor acetylhydrolase, isoform Ib, subunit 2 (30kDa) |
| Notes | Platelet-activating factor (PAF) is a biologically active phospholipid with diverse biologic effects. PAF is degraded to inactive products by hydrolysis of the acetyl group at the sn-2 position to produce the biologically inactive products LYSO-PAF and acetate. This reaction is catalyzed by PAF acetylhydrolase (PAFAH). The various monomeric and multimeric forms of the enzyme are composed of alpha (MIM 601545), beta, and gamma (MIM 603074) PAFAH subunits.[supplied by OMIM] |
| Pathway | reelin signaling pathway |
|---|---|
| Reelin signaling pathway | |
| Reelin signaling pathway |
| GO Molecular Function | hydrolase activity |
|---|---|
| hydrolase activity, acting on ester bonds | |
| platelet-activating factor acetyltransferase activity | |
| 1-alkyl-2-acetylglycerophosphocholine esterase activity |
| GO Cellular Component | cytoplasm |
|---|
| GO Biological Process | cellular component movement |
|---|---|
| spermatogenesis | |
| lipid metabolic process | |
| lipid catabolic process |
| Ariadne Ontology | Phospholipid biosynthesis |
|---|
| Group | Phospholipid biosynthesis |
|---|---|
| cellular component movement | |
| spermatogenesis | |
| lipid metabolic process | |
| lipid catabolic process | |
| hydrolase activity | |
| hydrolase activity, acting on ester bonds | |
| platelet-activating factor acetyltransferase activity | |
| 1-alkyl-2-acetylglycerophosphocholine esterase activity | |
| cytoplasm |
| MedScan ID | 5049 |
|---|
| Hugo ID | 8575 |
|---|
| Human chromosome position | 11q23 |
|---|
| LocusLink ID | 5049 |
|---|---|
| 18475 | |
| 64189 |
| Alias | platelet-activating factor acetylhydrolase IB subunit beta |
|---|---|
| PAFAH subunit beta | |
| PAF-AH subunit beta | |
| PAF-AH 30 kDa subunit | |
| PAF-AH1b alpha 2 subunit | |
| PAF acetylhydrolase 30 kDa subunit | |
| intracellular platelet-activating factor acetylhydrolase alpha 2 subunit | |
| platelet-activating factor acetylhydrolase, isoform Ib, subunit 2 (30kDa) | |
| Pafahb | |
| mus[b] | |
| AI747451 | |
| AU021353 | |
| platelet-activating factor acetylhydrolase, isoform 1b, alpha2 subunit | |
| MGC93124 | |
| PAF-AH alpha 2 | |
| platelet-activating factor acetylhydrolase, isoform Ib, subunit 2 | |
| platelet-activating factor acetylhydrolase, isoform Ib, beta subunit | |
| platelet-activating factor acetylhydrolase alpha 2 subunit (PAF-AH alpha 2) | |
| 30 kDa platelet-activating factor acetylhydrolase, isoform Ib, beta subunit | |
| mus(b) | |
| PAF-AH 30 | |
| PAFAH beta subunit | |
| PAF-AH beta subunit | |
| Pafah1b2 | |
| platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | |
| platelet-activating factor acetylhydrolase alpha 2 subunit | |
| Platelet-activating factor acetylhydrolase IB beta subunit | |
| platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 | |
| platelet-activating factor acetylhydrolase, isoform Ib, beta subunit (30kD) | |
| platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa | |
| PAF-AH 30 kDa subunit |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602508 |
|---|
| Mouse chromosome position | 9 |
|---|---|
| 9 A5.2 |
| GO ID | 0003847 |
|---|---|
| 0016788 | |
| 0016042 | |
| 0006629 | |
| 0007283 | |
| 0005737 | |
| 0016787 | |
| 0006928 | |
| 0047179 | |
| 0005515 | |
| 0016298 |
| Rat chromosome position | 8q22 |
|---|
| Swiss-Prot Accession | P68402 |
|---|---|
| Q6IBR6 | |
| Q9BUZ1 | |
| Q61206 | |
| Q8BTA2 | |
| O35264 | |
| Q6PKE6 | |
| Q7TNP3 | |
| O00687 | |
| Q29459 |
| PIR ID | JC5409 |
|---|
| Unigene ID | Hs.724435 |
|---|---|
| Mm.200859 | |
| Rn.24751 | |
| Hs.718419 |
| KEGG ID | hsa:5049 |
|---|---|
| mmu:18475 | |
| rno:64189 |
| EC Number | 3.1.1.47 |
|---|
| Swiss-Prot ID | PA1B2_MOUSE |
|---|---|
| PA1B2_HUMAN | |
| PA1B2_RAT | |
| Q6IBR6_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00118821 |
|---|---|
| IPI00026546 | |
| IPI00207335 | |
| IPI00815864 |
| Homologene ID | 1932 |
|---|
| RGD ID | 620332 |
|---|
| MGI ID | 108415 |
|---|