| URN | urn:agi-llid:2890 |
|---|---|
| Connectivity | 265 |
| Name | Gria1 |
| Description | glutamate receptor, ionotropic, AMPA 1 |
| Notes | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | reelin signaling pathway |
|---|---|
| Reelin signaling pathway | |
| Reelin signaling pathway |
| GO Molecular Function | protein domain specific binding |
|---|---|
| PDZ domain binding | |
| small GTPase binding | |
| protein kinase binding | |
| myosin V binding | |
| receptor activity | |
| glutamate receptor activity | |
| ionotropic glutamate receptor activity | |
| kainate selective glutamate receptor activity | |
| ion channel activity | |
| extracellular-glutamate-gated ion channel activity |
| GO Cellular Component | synapse |
|---|---|
| protein complex | |
| postsynaptic membrane | |
| postsynaptic density | |
| membrane | |
| asymmetric synapse | |
| plasma membrane | |
| neuronal cell body | |
| dendritic spine | |
| dendritic shaft | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| early endosome | |
| endocytic vesicle membrane | |
| membrane fraction | |
| synaptosome | |
| cell junction | |
| integral to membrane | |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex |
| GO Biological Process | transport |
|---|---|
| positive regulation of synaptic transmission | |
| regulation of synaptic transmission | |
| regulation of synaptic plasticity | |
| long-term memory | |
| signal transduction | |
| synaptic transmission | |
| regulation of receptor recycling | |
| receptor internalization | |
| regulation of action potential in neuron | |
| ion transport |
| Ariadne Ontology | K+ import-homeostasis |
|---|
| Group | K+ import-homeostasis |
|---|---|
| synapse | |
| transport | |
| positive regulation of synaptic transmission | |
| regulation of synaptic transmission | |
| regulation of synaptic plasticity | |
| long-term memory | |
| signal transduction | |
| synaptic transmission | |
| regulation of receptor recycling | |
| receptor internalization | |
| regulation of action potential in neuron | |
| ion transport | |
| protein domain specific binding | |
| PDZ domain binding | |
| small GTPase binding | |
| protein kinase binding | |
| myosin V binding | |
| receptor activity | |
| glutamate receptor activity | |
| ionotropic glutamate receptor activity | |
| kainate selective glutamate receptor activity | |
| ion channel activity | |
| extracellular-glutamate-gated ion channel activity | |
| protein complex | |
| postsynaptic membrane | |
| postsynaptic density | |
| membrane | |
| asymmetric synapse | |
| plasma membrane | |
| neuronal cell body | |
| dendritic spine | |
| dendritic shaft | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| early endosome | |
| endocytic vesicle membrane | |
| membrane fraction | |
| synaptosome | |
| cell junction | |
| integral to membrane | |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex |
| MedScan ID | 2890 |
|---|
| Hugo ID | 4571 |
|---|
| Human chromosome position | 5q33 |
|---|
| LocusLink ID | 2890 |
|---|---|
| 14799 |
| Alias | GLUH1 |
|---|---|
| GLUR1 | |
| GLURA | |
| GluA1 | |
| HBGR1 | |
| MGC133252 | |
| glutamate receptor 1 | |
| AMPA 1 | |
| gluR-1 | |
| gluR-A | |
| gluR-K1 | |
| AMPA-selective glutamate receptor 1 | |
| Glr1 | |
| Glr-1 | |
| HIPA1 | |
| AI853806 | |
| 2900051M01Rik | |
| RP23-102H8.1 | |
| OTTMUSP00000005878 | |
| OTTMUSP00000005879 | |
| glutamate receptor A | |
| glutamate receptor ionotropic, AMPA 1 | |
| 2900051M01 | |
| AMPA I | |
| Glr I | |
| GLUH I | |
| GLUR I | |
| GLUR-K I | |
| Glutamate receptor ionotropic, AMPA I | |
| glutamate receptor subunit glur1 | |
| glutamate receptor, ionotropic, AMPA1 (alpha 1) | |
| Gria I | |
| Gria1 | |
| HBGR I | |
| glutamate receptor, ionotropic, AMPA 1 | |
| Glutamate receptor ionotropic, AMPA 1 | |
| Glutamate receptor ionotropic, AMPA I | |
| RIKEN cDNA 2900051M01 gene | |
| Glutamate receptor 1 precursor | |
| glutamate receptor, ionotropic, AMPA |
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| OMIM ID | 138248 |
|---|
| Mouse chromosome position | 11 31.0 cM |
|---|
| GO ID | 0005234 |
|---|---|
| 0008066 | |
| 0005216 | |
| 0015277 | |
| 0004872 | |
| 0006811 | |
| 0007616 | |
| 0031623 | |
| 0007165 | |
| 0007268 | |
| 0032281 | |
| 0030054 | |
| 0030666 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0005624 | |
| 0005886 | |
| 0014069 | |
| 0045211 | |
| 0045202 | |
| 0030165 | |
| 0004970 | |
| 0031489 | |
| 0019904 | |
| 0019901 | |
| 0031267 | |
| 0050806 | |
| 0019228 | |
| 0001919 | |
| 0048167 | |
| 0050804 | |
| 0006810 | |
| 0032279 | |
| 0043198 | |
| 0043197 | |
| 0005769 | |
| 0016020 | |
| 0043025 | |
| 0043234 | |
| 0019717 | |
| 0005515 |
| Swiss-Prot Accession | P42261 |
|---|---|
| Q59GL5 | |
| P23818 | |
| Q6P9M2 | |
| Q7TNB5 | |
| Q5NBY0 | |
| Q5NBY1 | |
| Q5SSK5 | |
| Q9CUV0 | |
| Q9QXM6 | |
| Q2NKM6 | |
| D3DQI4 |
| PIR ID | S12874 |
|---|---|
| A40222 | |
| A41273 | |
| S25852 | |
| S38723 |
| Unigene ID | Hs.519693 |
|---|---|
| Mm.4920 |
| KEGG ID | hsa:2890 |
|---|---|
| mmu:14799 |
| Swiss-Prot ID | GRIA1_MOUSE |
|---|---|
| GRIA1_HUMAN | |
| Q6P9M2_MOUSE | |
| Q7TNB5_MOUSE | |
| D3DQI4_HUMAN | |
| Q59GL5_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Endoplasmic reticulum membrane | |
| Cell junction | |
| synapse | |
| postsynaptic cell membrane | |
| Plasma membrane |
| IPI ID | IPI00136965 |
|---|---|
| IPI00030880 | |
| IPI00219124 | |
| IPI00407939 | |
| IPI00853699 |
| Homologene ID | 20226 |
|---|
| RGD ID | 621531 |
|---|
| MGI ID | 95808 |
|---|