| URN | urn:agi-llid:1600 |
|---|---|
| Connectivity | 101 |
| Name | Dab1 |
| Description | disabled homolog 1 (Drosophila) |
| Notes | The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. |
| Pathway | reelin signaling pathway |
|---|---|
| Reelin signaling pathway | |
| Reelin signaling pathway | |
| Reelin signaling pathway |
| GO Molecular Function | phospholipid binding |
|---|---|
| SH2 domain binding | |
| phosphoinositide 3-kinase binding |
| GO Cellular Component | postsynaptic density |
|---|---|
| apical part of cell | |
| intracellular | |
| brush border | |
| neuron projection | |
| neuronal cell body | |
| perinuclear region of cytoplasm | |
| cytosol | |
| membrane fraction |
| GO Biological Process | multicellular organismal development |
|---|---|
| cerebellum structural organization | |
| cerebral cortex development | |
| cell differentiation | |
| nervous system development | |
| central nervous system development | |
| midgut development | |
| brain development | |
| negative regulation of cell adhesion | |
| small GTPase mediated signal transduction | |
| intracellular protein kinase cascade | |
| positive regulation of protein kinase activity | |
| neuron migration | |
| radial glia guided migration of Purkinje cell | |
| cerebral cortex cell migration | |
| cerebral cortex radially oriented cell migration | |
| cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration | |
| response to drug |
| Group | multicellular organismal development |
|---|---|
| cerebellum structural organization | |
| cerebral cortex development | |
| cell differentiation | |
| nervous system development | |
| central nervous system development | |
| midgut development | |
| brain development | |
| negative regulation of cell adhesion | |
| small GTPase mediated signal transduction | |
| intracellular protein kinase cascade | |
| positive regulation of protein kinase activity | |
| neuron migration | |
| radial glia guided migration of Purkinje cell | |
| cerebral cortex cell migration | |
| cerebral cortex radially oriented cell migration | |
| cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration | |
| response to drug | |
| phospholipid binding | |
| SH2 domain binding | |
| phosphoinositide 3-kinase binding | |
| postsynaptic density | |
| apical part of cell | |
| intracellular | |
| brush border | |
| neuron projection | |
| neuronal cell body | |
| perinuclear region of cytoplasm | |
| cytosol | |
| membrane fraction |
| MedScan ID | 1600 |
|---|
| Hugo ID | 2661 |
|---|
| Human chromosome position | 1p32-p31 |
|---|
| LocusLink ID | 1600 |
|---|---|
| 13131 | |
| 266729 |
| Alias | RP6-239D12.2 |
|---|---|
| disabled homolog 1 | |
| OTTHUMP00000010045 | |
| OTTHUMP00000011753 | |
| OTTHUMP00000011801 | |
| scm | |
| scr | |
| yot | |
| AI956902 | |
| scrambler | |
| C630028C02Rik | |
| RP23-356E21.1 | |
| yotari | |
| OTTMUSP00000008462 | |
| OTTMUSP00000008463 | |
| OTTMUSP00000008465 | |
| OTTMUSP00000008466 | |
| C630028C02 | |
| DAB I | |
| DAB1 | |
| disabled (Drosophila) homolog 1 | |
| disabled (Drosophila) homolog I | |
| disabled homolog 1 (Drosophila) | |
| disabled homolog I | |
| LOC545665 | |
| mammalian disabled 1 | |
| mammalian disabled I | |
| mDAB1 | |
| scrambler protein | |
| RIKEN cDNA C630028C02 gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603448 |
|---|
| Mouse chromosome position | 4 52.7 cM |
|---|
| GO ID | 0030154 |
|---|---|
| 0021813 | |
| 0021589 | |
| 0021799 | |
| 0007275 | |
| 0007162 | |
| 0007399 | |
| 0001764 | |
| 0045860 | |
| 0021942 | |
| 0007264 | |
| 0048471 | |
| 0042169 | |
| 0043548 | |
| 0005543 | |
| 0007417 | |
| 0021795 | |
| 0007243 | |
| 0045177 | |
| 0005903 | |
| 0005829 | |
| 0005622 | |
| 0005624 | |
| 0043005 | |
| 0043025 | |
| 0014069 | |
| 0007420 | |
| 0021987 | |
| 0007494 | |
| 0042493 | |
| 0005515 |
| Rat chromosome position | 5q34 |
|---|
| Swiss-Prot Accession | O75553 |
|---|---|
| Q8NFD0 | |
| P97318 | |
| B2RRQ8 | |
| Q8C423 | |
| Q8CJH2 | |
| A2A963 | |
| A2A964 | |
| A2A965 | |
| A2A966 | |
| A2A967 | |
| A2A970 | |
| P97316 | |
| P97317 | |
| Q9DAP9 | |
| A4FU90 | |
| B3KTG3 | |
| Q4LE59 | |
| Q5T6M6 | |
| Q5T6M9 | |
| Q5T835 | |
| Q5T836 | |
| Q5T837 | |
| Q6NWS9 | |
| Q6NWT0 | |
| Q6NWT1 | |
| Q9NYA8 |
| Unigene ID | Hs.477370 |
|---|---|
| Mm.289682 | |
| Rn.206534 |
| KEGG ID | hsa:1600 |
|---|---|
| mmu:13131 | |
| rno:266729 |
| Swiss-Prot ID | DAB1_RAT |
|---|---|
| DAB1_MOUSE | |
| DAB1_HUMAN | |
| B2RRQ8_MOUSE | |
| B3KTG3_HUMAN |
| IPI ID | IPI00194850 |
|---|---|
| IPI00123898 | |
| IPI00230573 | |
| IPI00230574 | |
| IPI00230575 | |
| IPI00750727 | |
| IPI00849536 | |
| IPI00850021 | |
| IPI00026889 | |
| IPI00433142 | |
| IPI00433150 | |
| IPI00514371 | |
| IPI00514638 | |
| IPI00847156 | |
| IPI00848179 | |
| IPI00225188 | |
| IPI00191489 |
| Homologene ID | 32084 |
|---|
| RGD ID | 628770 |
|---|
| MGI ID | 108554 |
|---|