| URN | urn:agi-llid:5649 |
|---|---|
| Connectivity | 169 |
| Name | Reln |
| Description | reelin |
| Notes | This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. |
| Pathway | reelin signaling pathway |
|---|---|
| Reelin signaling pathway | |
| Reelin signaling pathway | |
| Reelin signaling pathway |
| GO Molecular Function | hydrolase activity |
|---|---|
| metal ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| peptidase activity | |
| protein serine-threonine-tyrosine kinase activity | |
| serine-type peptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| perikaryon | |
| extracellular space | |
| neuron projection | |
| neuronal cell body | |
| cytoplasm | |
| axon | |
| dendrite | |
| proteinaceous extracellular matrix |
| GO Biological Process | cell adhesion |
|---|---|
| multicellular organismal development | |
| social behavior | |
| cerebral cortex development | |
| dentate gyrus development | |
| orbitofrontal cortex development | |
| hypothalamus development | |
| spinal cord patterning | |
| central nervous system development | |
| midgut development | |
| brain development | |
| glial cell differentiation | |
| cell morphogenesis involved in differentiation | |
| response to pain | |
| memory | |
| axon guidance | |
| positive regulation of small GTPase mediated signal transduction | |
| positive regulation of protein kinase activity | |
| neuron migration | |
| cerebral cortex tangential migration | |
| peptidyl-tyrosine phosphorylation | |
| cellular response to dexamethasone stimulus | |
| response to mechanical stimulus | |
| response to electrical stimulus | |
| response to drug | |
| response to toxin | |
| locomotory behavior | |
| response to hormone stimulus | |
| response to amino acid stimulus | |
| response to insecticide | |
| response to organic cyclic substance | |
| response to ethanol | |
| response to lithium ion | |
| response to fatty acid | |
| response to progesterone stimulus | |
| response to corticosterone stimulus | |
| response to axon injury | |
| thyroid hormone metabolic process |
| Ariadne Ontology | Extracellular matrix polymerization |
|---|
| Group | Extracellular matrix polymerization |
|---|---|
| extracellular region | |
| cell adhesion | |
| multicellular organismal development | |
| social behavior | |
| cerebral cortex development | |
| dentate gyrus development | |
| orbitofrontal cortex development | |
| hypothalamus development | |
| spinal cord patterning | |
| central nervous system development | |
| midgut development | |
| brain development | |
| glial cell differentiation | |
| cell morphogenesis involved in differentiation | |
| response to pain | |
| memory | |
| axon guidance | |
| positive regulation of small GTPase mediated signal transduction | |
| positive regulation of protein kinase activity | |
| neuron migration | |
| cerebral cortex tangential migration | |
| peptidyl-tyrosine phosphorylation | |
| cellular response to dexamethasone stimulus | |
| response to mechanical stimulus | |
| response to electrical stimulus | |
| response to drug | |
| response to toxin | |
| locomotory behavior | |
| response to hormone stimulus | |
| response to amino acid stimulus | |
| response to insecticide | |
| response to organic cyclic substance | |
| response to ethanol | |
| response to lithium ion | |
| response to fatty acid | |
| response to progesterone stimulus | |
| response to corticosterone stimulus | |
| response to axon injury | |
| thyroid hormone metabolic process | |
| hydrolase activity | |
| metal ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| peptidase activity | |
| protein serine-threonine-tyrosine kinase activity | |
| serine-type peptidase activity | |
| perikaryon | |
| extracellular space | |
| neuron projection | |
| neuronal cell body | |
| cytoplasm | |
| axon | |
| dendrite | |
| proteinaceous extracellular matrix |
| MedScan ID | 5649 |
|---|
| Hugo ID | 9957 |
|---|
| Human chromosome position | 7q22 |
|---|
| LocusLink ID | 5649 |
|---|---|
| 19699 | |
| 24718 |
| Alias | RL |
|---|---|
| PRO1598 | |
| reelin | |
| OTTHUMP00000211830 | |
| reeler | |
| extracellular matrix serine protease | |
| Reelen | |
| reeler protein | |
| RELN |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600514 |
|---|---|
| 257320 |
| Mouse chromosome position | 5 8.0 cM |
|---|
| GO ID | 0046872 |
|---|---|
| 0008233 | |
| 0004712 | |
| 0008236 | |
| 0007411 | |
| 0007420 | |
| 0007155 | |
| 0000904 | |
| 0007417 | |
| 0021800 | |
| 0010001 | |
| 0007275 | |
| 0001764 | |
| 0018108 | |
| 0045860 | |
| 0051057 | |
| 0048265 | |
| 0021511 | |
| 0005737 | |
| 0030425 | |
| 0005576 | |
| 0005615 | |
| 0005578 | |
| 0016787 | |
| 0021542 | |
| 0007626 | |
| 0042403 | |
| 0030424 | |
| 0043005 | |
| 0043025 | |
| 0043204 | |
| 0071549 | |
| 0021987 | |
| 0021854 | |
| 0007613 | |
| 0007494 | |
| 0021769 | |
| 0043200 | |
| 0048678 | |
| 0051412 | |
| 0042493 | |
| 0051602 | |
| 0045471 | |
| 0070542 | |
| 0009725 | |
| 0017085 | |
| 0010226 | |
| 0009612 | |
| 0014070 | |
| 0032570 | |
| 0009636 | |
| 0035176 | |
| 0005509 | |
| 0008270 | |
| 0005515 | |
| 0004252 |
| Rat chromosome position | 4q11.2 |
|---|
| Swiss-Prot Accession | A4D0P9 |
|---|---|
| P78509 | |
| Q75MM8 | |
| Q60841 | |
| Q148P9 | |
| Q64FW1 | |
| Q8C978 | |
| Q8CBK6 | |
| P58751 | |
| Q9CUA6 | |
| A4D0Q0 | |
| Q86UJ0 | |
| Q86UJ8 | |
| Q8NDV0 | |
| Q9UDQ2 | |
| Q80T65 |
| PIR ID | S58870 |
|---|
| Unigene ID | Hs.655654 |
|---|---|
| Mm.425236 | |
| Rn.222531 | |
| Rn.98353 |
| KEGG ID | hsa:5649 |
|---|---|
| mmu:19699 | |
| rno:24718 |
| EC Number | 3.4.21.- |
|---|
| Swiss-Prot ID | RELN_MOUSE |
|---|---|
| RELN_HUMAN | |
| RELN_RAT | |
| A4D0P9_HUMAN |
| Cell Localization | Secreted |
|---|---|
| extracellular space | |
| extracellular matrix | |
| Extracellular |
| IPI ID | IPI00121421 |
|---|---|
| IPI00230330 | |
| IPI00230331 | |
| IPI00241562 | |
| IPI00294776 | |
| IPI00847589 | |
| IPI00202873 | |
| IPI00337207 | |
| IPI00337208 | |
| IPI00828831 | |
| IPI00228349 | |
| IPI00886066 | |
| IPI00387954 |
| Homologene ID | 3699 |
|---|
| RGD ID | 3553 |
|---|
| MGI ID | 103022 |
|---|