| URN | urn:agi-llid:2903 |
|---|---|
| Connectivity | 173 |
| Name | Grin2a |
| Description | glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
| Notes | N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | reelin signaling pathway |
|---|---|
| Reelin signaling pathway | |
| Reelin signaling pathway |
| GO Molecular Function | transporter activity |
|---|---|
| neurotransmitter binding | |
| protein complex binding | |
| cell adhesion molecule binding | |
| ATPase binding | |
| glutamate receptor binding | |
| protein kinase binding | |
| glutamate binding | |
| metal ion binding | |
| magnesium ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| receptor activity | |
| ionotropic glutamate receptor activity | |
| N-methyl-D-aspartate selective glutamate receptor activity | |
| ion channel activity | |
| cation channel activity | |
| calcium channel activity | |
| voltage-gated cation channel activity | |
| extracellular-glutamate-gated ion channel activity |
| GO Cellular Component | synapse |
|---|---|
| presynaptic membrane | |
| postsynaptic membrane | |
| postsynaptic density | |
| membrane | |
| plasma membrane | |
| outer membrane-bounded periplasmic space | |
| neuron projection | |
| dendritic spine | |
| membrane fraction | |
| synaptosome | |
| flotillin complex | |
| cell junction | |
| integral to membrane | |
| integral to plasma membrane | |
| N-methyl-D-aspartate selective glutamate receptor complex | |
| terminal button |
| GO Biological Process | locomotion |
|---|---|
| rhythmic process | |
| sleep | |
| response to other organism | |
| directional locomotion | |
| transport | |
| cerebral cortex development | |
| spinal cord development | |
| hippocampus development | |
| neurogenesis | |
| visual learning | |
| regulation of synaptic transmission | |
| regulation of sensory perception of pain | |
| regulation of synaptic plasticity | |
| regulation of long-term neuronal synaptic plasticity | |
| learning or memory | |
| startle response | |
| memory | |
| learning | |
| sensory perception of pain | |
| positive regulation of cell death | |
| synaptic transmission | |
| positive regulation of apoptosis | |
| serotonin metabolic process | |
| dopamine metabolic process | |
| regulation of membrane potential | |
| regulation of action potential | |
| regulation of postsynaptic membrane potential | |
| regulation of excitatory postsynaptic membrane potential | |
| cellular response to growth factor stimulus | |
| cellular response to lipid | |
| cellular response to dsRNA | |
| cellular response to protein stimulus | |
| cellular response to amino acid stimulus | |
| cellular response to zinc ion | |
| cellular response to magnesium ion | |
| cellular response to manganese ion | |
| response to drug | |
| locomotory behavior | |
| response to wounding | |
| response to ammonium ion | |
| response to fungicide | |
| response to organic cyclic substance | |
| response to methylmercury | |
| response to carbohydrate stimulus | |
| response to ethanol | |
| response to manganese ion | |
| response to calcium ion | |
| response to cocaine | |
| response to amine stimulus | |
| response to amphetamine | |
| detection of mechanical stimulus involved in sensory perception of pain | |
| response to light stimulus | |
| negative regulation of protein catabolic process | |
| ion transport | |
| calcium ion transport | |
| glutamate signaling pathway | |
| ionotropic glutamate receptor signaling pathway | |
| protein localization |
| Group | synapse |
|---|---|
| transporter activity | |
| locomotion | |
| rhythmic process | |
| sleep | |
| response to other organism | |
| directional locomotion | |
| transport | |
| cerebral cortex development | |
| spinal cord development | |
| hippocampus development | |
| neurogenesis | |
| visual learning | |
| regulation of synaptic transmission | |
| regulation of sensory perception of pain | |
| regulation of synaptic plasticity | |
| regulation of long-term neuronal synaptic plasticity | |
| learning or memory | |
| startle response | |
| memory | |
| learning | |
| sensory perception of pain | |
| positive regulation of cell death | |
| synaptic transmission | |
| positive regulation of apoptosis | |
| serotonin metabolic process | |
| dopamine metabolic process | |
| regulation of membrane potential | |
| regulation of action potential | |
| regulation of postsynaptic membrane potential | |
| regulation of excitatory postsynaptic membrane potential | |
| cellular response to growth factor stimulus | |
| cellular response to lipid | |
| cellular response to dsRNA | |
| cellular response to protein stimulus | |
| cellular response to amino acid stimulus | |
| cellular response to zinc ion | |
| cellular response to magnesium ion | |
| cellular response to manganese ion | |
| response to drug | |
| locomotory behavior | |
| response to wounding | |
| response to ammonium ion | |
| response to fungicide | |
| response to organic cyclic substance | |
| response to methylmercury | |
| response to carbohydrate stimulus | |
| response to ethanol | |
| response to manganese ion | |
| response to calcium ion | |
| response to cocaine | |
| response to amine stimulus | |
| response to amphetamine | |
| detection of mechanical stimulus involved in sensory perception of pain | |
| response to light stimulus | |
| negative regulation of protein catabolic process | |
| ion transport | |
| calcium ion transport | |
| glutamate signaling pathway | |
| ionotropic glutamate receptor signaling pathway | |
| protein localization | |
| neurotransmitter binding | |
| protein complex binding | |
| cell adhesion molecule binding | |
| ATPase binding | |
| glutamate receptor binding | |
| protein kinase binding | |
| glutamate binding | |
| metal ion binding | |
| magnesium ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| receptor activity | |
| ionotropic glutamate receptor activity | |
| N-methyl-D-aspartate selective glutamate receptor activity | |
| ion channel activity | |
| cation channel activity | |
| calcium channel activity | |
| voltage-gated cation channel activity | |
| extracellular-glutamate-gated ion channel activity | |
| presynaptic membrane | |
| postsynaptic membrane | |
| postsynaptic density | |
| membrane | |
| plasma membrane | |
| outer membrane-bounded periplasmic space | |
| neuron projection | |
| dendritic spine | |
| membrane fraction | |
| synaptosome | |
| flotillin complex | |
| cell junction | |
| integral to membrane | |
| integral to plasma membrane | |
| N-methyl-D-aspartate selective glutamate receptor complex | |
| terminal button |
| MedScan ID | 2903 |
|---|
| Hugo ID | 4585 |
|---|
| Human chromosome position | 16p13.2 |
|---|
| LocusLink ID | 2903 |
|---|---|
| 14811 | |
| 24409 |
| Alias | NR2A |
|---|---|
| NMDAR2A | |
| glutamate [NMDA] receptor subunit epsilon-1 | |
| hNR2A | |
| OTTHUMP00000160135 | |
| OTTHUMP00000174531 | |
| NMDA receptor subtype 2A | |
| N-methyl D-aspartate receptor subtype 2A | |
| N-methyl-D-aspartate receptor subunit 2A | |
| N-methyl-D-aspartate receptor channel, subunit epsilon-1 | |
| GluRepsilon1 | |
| OTTMUSP00000017426 | |
| GRIN2A | |
| GluRepsilon I | |
| Glutamate (NMDA) receptor subunit epsilon 1 | |
| glutamate receptor, ionotropic, NMDA2A (epsilon 1) | |
| glutamate receptor, ionotropic, N-methyl D-aspartate 2A | |
| NMDA2A | |
| N-methyl D- aspartate receptor subtype 2A | |
| N-methyl-D-aspartate receptor subunit 2A precursor | |
| Glutamate (NMDA) receptor subunit epsilon 1 precursor |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 138253 |
|---|
| Mouse chromosome position | 16 3.4 cM |
|---|
| GO ID | 0004972 |
|---|---|
| 0005262 | |
| 0050839 | |
| 0005234 | |
| 0016595 | |
| 0046872 | |
| 0042165 | |
| 0004872 | |
| 0005215 | |
| 0022843 | |
| 0008270 | |
| 0006816 | |
| 0033058 | |
| 0042417 | |
| 0007215 | |
| 0006811 | |
| 0035235 | |
| 0007612 | |
| 0007611 | |
| 0007613 | |
| 0042177 | |
| 0022008 | |
| 0043065 | |
| 0008104 | |
| 0001508 | |
| 0060079 | |
| 0048169 | |
| 0051930 | |
| 0048167 | |
| 0001975 | |
| 0042493 | |
| 0045471 | |
| 0009611 | |
| 0048511 | |
| 0042428 | |
| 0030431 | |
| 0001964 | |
| 0007268 | |
| 0006810 | |
| 0008542 | |
| 0017146 | |
| 0030054 | |
| 0043197 | |
| 0005887 | |
| 0043005 | |
| 0030288 | |
| 0005886 | |
| 0014069 | |
| 0045211 | |
| 0042734 | |
| 0045202 | |
| 0019717 | |
| 0051117 | |
| 0005261 | |
| 0035254 | |
| 0005216 | |
| 0004970 | |
| 0032403 | |
| 0019901 | |
| 0071230 | |
| 0071445 | |
| 0071294 | |
| 0050966 | |
| 0040011 | |
| 0007626 | |
| 0010942 | |
| 0042391 | |
| 0060078 | |
| 0050804 | |
| 0019233 | |
| 0016600 | |
| 0016021 | |
| 0016020 | |
| 0005624 | |
| 0043195 | |
| 0071359 | |
| 0071363 | |
| 0071396 | |
| 0071286 | |
| 0071287 | |
| 0021987 | |
| 0021766 | |
| 0014075 | |
| 0060359 | |
| 0051592 | |
| 0009743 | |
| 0042220 | |
| 0060992 | |
| 0009416 | |
| 0010042 | |
| 0051597 | |
| 0014070 | |
| 0051707 | |
| 0021510 | |
| 0005509 | |
| 0000287 | |
| 0005515 | |
| 0005737 |
| Rat chromosome position | 10q11 |
|---|
| Swiss-Prot Accession | Q12879 |
|---|---|
| Q547U9 | |
| Q59EW6 | |
| B4DII7 | |
| Q17RZ6 | |
| P35436 | |
| Q00959 | |
| Q8CGM3 | |
| Q8VDA3 | |
| O00669 | |
| O08948 | |
| Q63728 |
| PIR ID | S47555 |
|---|---|
| A43274 | |
| S29159 |
| Unigene ID | Hs.411472 |
|---|---|
| Mm.2953 | |
| Rn.9710 |
| KEGG ID | hsa:2903 |
|---|---|
| mmu:14811 | |
| rno:24409 |
| Swiss-Prot ID | NMDE1_HUMAN |
|---|---|
| NMDE1_RAT | |
| NMDE1_MOUSE | |
| Q547U9_HUMAN | |
| Q59EW6_HUMAN | |
| B4DII7_HUMAN | |
| Q17RZ6_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Cell junction | |
| synapse | |
| postsynaptic cell membrane |
| IPI ID | IPI00029768 |
|---|---|
| IPI00326054 | |
| IPI00118380 | |
| IPI00902706 |
| Homologene ID | 645 |
|---|
| RGD ID | 2737 |
|---|
| MGI ID | 95820 |
|---|