| URN | urn:agi-llid:3675 |
|---|---|
| Connectivity | 111 |
| Name | Itga3 |
| Description | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) |
| Notes | The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq] |
| Pathway | reelin signaling pathway |
|---|---|
| Reelin signaling pathway | |
| Reelin signaling pathway |
| GO Molecular Function | collagen binding |
|---|---|
| laminin binding | |
| protein domain specific binding | |
| fibronectin binding | |
| integrin binding | |
| protein heterodimerization activity | |
| calcium ion binding | |
| receptor activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| plasma membrane | |
| growth cone | |
| perinuclear region of cytoplasm | |
| synaptosome | |
| basolateral plasma membrane | |
| integrin complex | |
| integral to membrane | |
| alpha3-beta1 integrin complex |
| GO Biological Process | cell adhesion |
|---|---|
| heart development | |
| positive regulation of neuron projection development | |
| maternal process involved in female pregnancy | |
| positive regulation of epithelial cell migration | |
| memory | |
| negative regulation of cell projection organization | |
| positive regulation of cell-substrate adhesion | |
| fusion of sperm to egg plasma membrane | |
| neuron migration | |
| cell-matrix adhesion | |
| response to drug | |
| response to gonadotropin stimulus | |
| positive regulation of gene expression | |
| integrin-mediated signaling pathway |
| Ariadne Ontology | ITG |
|---|
| Group | ITG |
|---|---|
| cell adhesion | |
| heart development | |
| positive regulation of neuron projection development | |
| maternal process involved in female pregnancy | |
| positive regulation of epithelial cell migration | |
| memory | |
| negative regulation of cell projection organization | |
| positive regulation of cell-substrate adhesion | |
| fusion of sperm to egg plasma membrane | |
| neuron migration | |
| cell-matrix adhesion | |
| response to drug | |
| response to gonadotropin stimulus | |
| positive regulation of gene expression | |
| integrin-mediated signaling pathway | |
| collagen binding | |
| laminin binding | |
| protein domain specific binding | |
| fibronectin binding | |
| integrin binding | |
| protein heterodimerization activity | |
| calcium ion binding | |
| receptor activity | |
| cell surface | |
| membrane | |
| plasma membrane | |
| growth cone | |
| perinuclear region of cytoplasm | |
| synaptosome | |
| basolateral plasma membrane | |
| integrin complex | |
| integral to membrane | |
| alpha3-beta1 integrin complex |
| MedScan ID | 3675 |
|---|
| Hugo ID | 6139 |
|---|
| Human chromosome position | 17q21.33 |
|---|
| LocusLink ID | 3675 |
|---|---|
| 16400 | |
| 360606 |
| Alias | VL3A |
|---|---|
| CD49C | |
| GAPB3 | |
| MSK18 | |
| VCA-2 | |
| VLA3a | |
| GAP-B3 | |
| FLJ34631 | |
| FLJ34704 | |
| integrin alpha-3 | |
| FRP-2 | |
| galactoprotein B3 | |
| VLA-3 subunit alpha | |
| CD49 antigen-like family member C | |
| antigen identified by monoclonal antibody J143 | |
| very late activation protein 3 receptor, alpha-3 subunit | |
| AA407068 | |
| RP23-112C19.6 | |
| VLA-3 alpha 3 | |
| alpha3-integrin | |
| OTTMUSP00000001529 | |
| OTTMUSP00000001530 | |
| OTTMUSP00000001531 | |
| VLA-3 receptor, alpha 3 subunit | |
| alpha 3 a integrin | |
| alpha 3 subunit of VLA-3 receptor | |
| alpha 3 subunit of VLA-3 receptors | |
| alpha iii integrin | |
| alpha-3 Integrin | |
| integrin alpha 3 | |
| integrin alpha 3 (Cd49c) | |
| integrin alpha 3 isoform a | |
| integrin alpha 3 isoform b, | |
| Integrin alpha III | |
| integrin VLA-3 alpha-3 chain | |
| integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | |
| ITA3 | |
| ITA3_HUMAN | |
| Itga3 | |
| VLA-3 alpha | |
| VLA-3 receptor alpha 3 subunit | |
| VLA3-alpha3 | |
| integrin alpha 3 isoform a precursor | |
| integrin VLA-3 alpha-3 chain precursor | |
| integrin alpha 3 isoform b, precursor | |
| GAP-B3s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605025 |
|---|
| Mouse chromosome position | 11 56.0 cM |
|---|
| GO ID | 0004872 |
|---|---|
| 0007155 | |
| 0007160 | |
| 0007229 | |
| 0016021 | |
| 0008305 | |
| 0005886 | |
| 0005518 | |
| 0001968 | |
| 0005178 | |
| 0043236 | |
| 0019904 | |
| 0046982 | |
| 0007342 | |
| 0007613 | |
| 0031345 | |
| 0001764 | |
| 0010811 | |
| 0010634 | |
| 0010628 | |
| 0010976 | |
| 0034667 | |
| 0016323 | |
| 0009986 | |
| 0030426 | |
| 0016020 | |
| 0048471 | |
| 0019717 | |
| 0007507 | |
| 0060135 | |
| 0042493 | |
| 0034698 | |
| 0005509 | |
| 0005515 |
| Rat chromosome position | 10q31 |
|---|
| Swiss-Prot Accession | P26006 |
|---|---|
| Q59F03 | |
| Q86SW1 | |
| Q62470 | |
| Q5SWA8 | |
| Q6P6I1 | |
| Q8C8X8 | |
| Q8K4Q3 | |
| Q08441 | |
| Q08442 | |
| Q5SWB9 | |
| A7E246 | |
| B9EGQ1 | |
| D3DTX4 | |
| D3DTX5 |
| PIR ID | B41543 |
|---|---|
| I55534 | |
| A40021 |
| Unigene ID | Hs.265829 |
|---|---|
| Mm.57035 | |
| Rn.154664 |
| KEGG ID | hsa:3675 |
|---|---|
| mmu:16400 | |
| rno:360606 |
| Swiss-Prot ID | ITA3_MOUSE |
|---|---|
| ITA3_HUMAN | |
| D3DTX4_HUMAN | |
| D3DTX5_HUMAN | |
| B9EGQ1_HUMAN | |
| Q5SWB9_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00126090 |
|---|---|
| IPI00468674 | |
| IPI00215995 | |
| IPI00290043 | |
| IPI00648237 | |
| IPI00894660 | |
| IPI00372689 | |
| IPI00389072 | |
| IPI00776642 |
| Homologene ID | 21129 |
|---|
| RGD ID | 1310333 |
|---|
| MGI ID | 96602 |
|---|