| URN | urn:agi-llid:2534 |
|---|---|
| Connectivity | 706 |
| Name | Fyn |
| Description | fyn proto-oncogene |
| Notes | may mediate tyrosine phosphorylation of Cbl protein in cerebellum in response to ethanol administration [RGD] |
| Pathway | EphrinR -> STAT signaling |
|---|---|
| NCAM1 -> CREB/ELK-SRF/MYC signaling | |
| IL7R -> FOXO/NF-kB signaling | |
| CD2 -> NFATC1 signaling | |
| T-cell receptor -> AP-1 signaling | |
| T-cell receptor -> ATF/CREB signaling | |
| T-cell receptor -> CREBBP signaling | |
| T-cell receptor -> NF-kB signaling | |
| T-cell receptor -> NFATC signaling | |
| T-cell receptor -> STAT signaling | |
| PTPRC -> BCL6 signaling | |
| UrokinaseR -> ELK-SRF signaling | |
| CholinergicRn -> CREB signaling | |
| vascular endothelial growth factor signaling pathway | |
| reelin signaling pathway | |
| Reelin signaling pathway | |
| Reelin signaling pathway | |
| Reelin signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| glycoprotein binding | |
| protein complex binding | |
| receptor binding | |
| tubulin binding | |
| T cell receptor binding | |
| CD4 receptor binding | |
| CD8 receptor binding | |
| peptide hormone receptor binding | |
| phosphoinositide 3-kinase binding | |
| ATP binding | |
| metal ion binding | |
| manganese ion binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| non-membrane spanning protein tyrosine kinase activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| endosome | |
| cytosol | |
| mitochondrial envelope | |
| membrane fraction | |
| microsome |
| GO Biological Process | multicellular organismal development |
|---|---|
| interspecies interaction between organisms | |
| forebrain development | |
| regulation of cell shape | |
| learning | |
| intracellular protein kinase cascade | |
| activated T cell proliferation | |
| neuron migration | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| myelination | |
| cellular response to growth factor stimulus | |
| cellular response to peptide hormone stimulus | |
| T cell receptor signaling pathway | |
| response to drug | |
| feeding behavior | |
| response to ethanol | |
| detection of mechanical stimulus involved in sensory perception of pain | |
| calcium ion transport | |
| cell surface receptor linked signaling pathway | |
| ionotropic glutamate receptor signaling pathway |
| Ariadne Ontology | Src |
|---|---|
| Oncogenes |
| Group | Src |
|---|---|
| Oncogenes | |
| multicellular organismal development | |
| interspecies interaction between organisms | |
| forebrain development | |
| regulation of cell shape | |
| learning | |
| intracellular protein kinase cascade | |
| activated T cell proliferation | |
| neuron migration | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| myelination | |
| cellular response to growth factor stimulus | |
| cellular response to peptide hormone stimulus | |
| T cell receptor signaling pathway | |
| response to drug | |
| feeding behavior | |
| response to ethanol | |
| detection of mechanical stimulus involved in sensory perception of pain | |
| calcium ion transport | |
| cell surface receptor linked signaling pathway | |
| ionotropic glutamate receptor signaling pathway | |
| nucleotide binding | |
| transferase activity | |
| glycoprotein binding | |
| protein complex binding | |
| receptor binding | |
| tubulin binding | |
| T cell receptor binding | |
| CD4 receptor binding | |
| CD8 receptor binding | |
| peptide hormone receptor binding | |
| phosphoinositide 3-kinase binding | |
| ATP binding | |
| metal ion binding | |
| manganese ion binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| non-membrane spanning protein tyrosine kinase activity | |
| membrane | |
| plasma membrane | |
| endosome | |
| cytosol | |
| mitochondrial envelope | |
| membrane fraction | |
| microsome |
| MedScan ID | 2534 |
|---|
| Hugo ID | 4037 |
|---|
| Human chromosome position | 6q21 |
|---|
| LocusLink ID | 2534 |
|---|---|
| 14360 | |
| 25150 |
| Alias | SLK |
|---|---|
| SYN | |
| MGC45350 | |
| RP1-66H14.1 | |
| tyrosine-protein kinase Fyn | |
| p59-Fyn | |
| src-like kinase | |
| OTTHUMP00000017916 | |
| OTTHUMP00000017917 | |
| proto-oncogene Syn | |
| c-syn protooncogene | |
| proto-oncogene c-Fyn | |
| src/yes-related novel | |
| tyrosine kinase p59fyn(T) | |
| protein-tyrosine kinase fyn | |
| OKT3-induced calcium influx regulator | |
| proto-oncogene tyrosine-protein kinase fyn | |
| AI448320 | |
| AW552119 | |
| MGC115870 | |
| Src Kinase p59 | |
| OTTMUSP00000046779 | |
| OTTMUSP00000046780 | |
| OTTMUSP00000046781 | |
| OTTMUSP00000046784 | |
| fyn proto-oncogene | |
| Feline yes-related protein | |
| Fyn | |
| FYN oncogene related to SRC, FGR, YES | |
| Fyn SH2 domain | |
| OTTHUMP00000017914 | |
| OTTHUMP00000017915 | |
| p59fyn(T) | |
| protein-tyrosine kinase fyn isoform a | |
| protein-tyrosine kinase fyn isoform b | |
| protein-tyrosine kinase fyn isoform c | |
| Src-family kinase fyn | |
| Src-family protein-tyrosine kinase fyn | |
| tyrosine kinase p59fyn | |
| src/yes-related novel gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 137025 |
|---|
| Mouse chromosome position | 10 25.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0001948 | |
| 0046872 | |
| 0004715 | |
| 0000166 | |
| 0004713 | |
| 0016740 | |
| 0015631 | |
| 0050852 | |
| 0050798 | |
| 0006816 | |
| 0007166 | |
| 0050966 | |
| 0007631 | |
| 0030900 | |
| 0044419 | |
| 0007243 | |
| 0007612 | |
| 0007275 | |
| 0001764 | |
| 0018108 | |
| 0046777 | |
| 0006468 | |
| 0008360 | |
| 0045471 | |
| 0005829 | |
| 0005768 | |
| 0005740 | |
| 0005886 | |
| 0042609 | |
| 0042610 | |
| 0042608 | |
| 0016301 | |
| 0051428 | |
| 0043548 | |
| 0032403 | |
| 0004672 | |
| 0005102 | |
| 0042552 | |
| 0016020 | |
| 0005624 | |
| 0005792 | |
| 0071363 | |
| 0071375 | |
| 0035235 | |
| 0042493 | |
| 0030145 | |
| 0042802 | |
| 0005515 | |
| 0048168 | |
| 0008372 | |
| 0008542 | |
| 0007242 |
| Rat chromosome position | 20q13 |
|---|
| Swiss-Prot Accession | P06241 |
|---|---|
| Q5R3A8 | |
| P39688 | |
| Q62844 | |
| B5BU57 | |
| Q16248 | |
| Q5R3A6 | |
| Q5R3A7 | |
| Q8N5D7 | |
| Q3TAT3 | |
| Q3U0T5 | |
| Q8K2A3 |
| PIR ID | PT0199 |
|---|---|
| A24314 | |
| A44991 |
| Unigene ID | Hs.390567 |
|---|---|
| Mm.4848 | |
| Rn.19361 | |
| Mm.28844 |
| KEGG ID | hsa:2534 |
|---|---|
| mmu:14360 | |
| rno:25150 |
| EC Number | 2.7.10.2 |
|---|---|
| 2.7.10.1 |
| Swiss-Prot ID | FYN_RAT |
|---|---|
| FYN_HUMAN | |
| FYN_MOUSE | |
| B5BU57_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Cytoplasm |
| IPI ID | IPI00209210 |
|---|---|
| IPI00166845 | |
| IPI00219012 | |
| IPI00640091 | |
| IPI00322097 | |
| IPI00762435 | |
| IPI00639876 | |
| IPI00189160 |
| Homologene ID | 48068 |
|---|
| RGD ID | 2641 |
|---|
| MGI ID | 95602 |
|---|
| Source | Curated |
|---|