| URN | urn:agi-llid:3688 |
|---|---|
| Connectivity | 1043 |
| Name | Itgb1 |
| Description | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) |
| Notes | Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | FibronectinR -> ICAP-1A/MYC signaling |
|---|---|
| FibronectinR -> NF-kB signaling | |
| FibronectinR -> CTNNB signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| reelin signaling pathway | |
| Reelin signaling pathway | |
| Reelin signaling pathway |
| GO Molecular Function | peptide binding |
|---|---|
| collagen binding | |
| glycoprotein binding | |
| laminin binding | |
| protein domain specific binding | |
| protein complex binding | |
| fibronectin binding | |
| receptor binding | |
| actin binding | |
| integrin binding | |
| kinase binding | |
| protease binding | |
| protein heterodimerization activity | |
| protein kinase binding | |
| alpha-actinin binding | |
| receptor activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| neuromuscular junction | |
| plasma membrane | |
| ruffle | |
| membrane raft | |
| melanosome | |
| acrosomal vesicle | |
| membrane fraction | |
| synaptosome | |
| integrin complex | |
| integral to membrane | |
| ruffle membrane | |
| cell-cell junction | |
| alpha3-beta1 integrin complex | |
| alpha9-beta1 integrin complex | |
| adherens junction | |
| hemidesmosome | |
| focal adhesion | |
| sarcolemma | |
| basement membrane |
| GO Biological Process | cell adhesion |
|---|---|
| negative regulation of cell proliferation | |
| positive regulation of cell proliferation | |
| interspecies interaction between organisms | |
| response to activity | |
| negative regulation of cell differentiation | |
| cell fate specification | |
| negative regulation of neuron differentiation | |
| positive regulation of neuron differentiation | |
| positive regulation of neuron projection development | |
| cardiac muscle cell differentiation | |
| neuron projection morphogenesis | |
| B cell differentiation | |
| in utero embryonic development | |
| maternal process involved in female pregnancy | |
| regulation of cell cycle | |
| germ cell migration | |
| G1-S transition of mitotic cell cycle | |
| protein transport within lipid bilayer | |
| positive regulation of endocytosis | |
| negative regulation of cell projection organization | |
| neuron projection development | |
| positive regulation of MAPKKK cascade | |
| cellular response to vitamin D | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of cell migration | |
| positive regulation of cell-substrate adhesion | |
| cell migration | |
| homophilic cell adhesion | |
| cell-cell adhesion mediated by integrin | |
| leukocyte cell-cell adhesion | |
| cell-matrix adhesion | |
| cellular calcium ion homeostasis | |
| sarcomere organization | |
| cellular response to mechanical stimulus | |
| cellular response to protein stimulus | |
| cellular response to ionizing radiation | |
| tight junction assembly | |
| response to drug | |
| response to transforming growth factor beta stimulus | |
| response to gonadotropin stimulus | |
| cellular defense response | |
| response to nutrient levels | |
| regulation of G-protein coupled receptor protein signaling pathway | |
| integrin-mediated signaling pathway | |
| tissue homeostasis |
| Ariadne Ontology | ITG |
|---|
| Group | ITG |
|---|---|
| cell adhesion | |
| negative regulation of cell proliferation | |
| positive regulation of cell proliferation | |
| interspecies interaction between organisms | |
| response to activity | |
| negative regulation of cell differentiation | |
| cell fate specification | |
| negative regulation of neuron differentiation | |
| positive regulation of neuron differentiation | |
| positive regulation of neuron projection development | |
| cardiac muscle cell differentiation | |
| neuron projection morphogenesis | |
| B cell differentiation | |
| in utero embryonic development | |
| maternal process involved in female pregnancy | |
| regulation of cell cycle | |
| germ cell migration | |
| G1-S transition of mitotic cell cycle | |
| protein transport within lipid bilayer | |
| positive regulation of endocytosis | |
| negative regulation of cell projection organization | |
| neuron projection development | |
| positive regulation of MAPKKK cascade | |
| cellular response to vitamin D | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of cell migration | |
| positive regulation of cell-substrate adhesion | |
| cell migration | |
| homophilic cell adhesion | |
| cell-cell adhesion mediated by integrin | |
| leukocyte cell-cell adhesion | |
| cell-matrix adhesion | |
| cellular calcium ion homeostasis | |
| sarcomere organization | |
| cellular response to mechanical stimulus | |
| cellular response to protein stimulus | |
| cellular response to ionizing radiation | |
| tight junction assembly | |
| response to drug | |
| response to transforming growth factor beta stimulus | |
| response to gonadotropin stimulus | |
| cellular defense response | |
| response to nutrient levels | |
| regulation of G-protein coupled receptor protein signaling pathway | |
| integrin-mediated signaling pathway | |
| tissue homeostasis | |
| peptide binding | |
| collagen binding | |
| glycoprotein binding | |
| laminin binding | |
| protein domain specific binding | |
| protein complex binding | |
| fibronectin binding | |
| receptor binding | |
| actin binding | |
| integrin binding | |
| kinase binding | |
| protease binding | |
| protein heterodimerization activity | |
| protein kinase binding | |
| alpha-actinin binding | |
| receptor activity | |
| cell surface | |
| membrane | |
| neuromuscular junction | |
| plasma membrane | |
| ruffle | |
| membrane raft | |
| melanosome | |
| acrosomal vesicle | |
| membrane fraction | |
| synaptosome | |
| integrin complex | |
| integral to membrane | |
| ruffle membrane | |
| cell-cell junction | |
| alpha3-beta1 integrin complex | |
| alpha9-beta1 integrin complex | |
| adherens junction | |
| hemidesmosome | |
| focal adhesion | |
| sarcolemma | |
| basement membrane |
| MedScan ID | 3688 |
|---|
| Hugo ID | 6153 |
|---|
| Human chromosome position | 10p11.2 |
|---|
| LocusLink ID | 3688 |
|---|---|
| 16412 | |
| 24511 |
| Alias | CD29 |
|---|---|
| FNRB | |
| MDF2 | |
| VLAB | |
| GPIIA | |
| MSK12 | |
| VLA-BETA | |
| RP11-479G22.2 | |
| integrin beta-1 | |
| VLA-4 subunit beta | |
| integrin VLA-4 beta subunit | |
| fibronectin receptor beta subunit | |
| fibronectin receptor subunit beta | |
| AA409975 | |
| AA960159 | |
| 4633401G24Rik | |
| beta OL | |
| beta oligodendroglia | |
| integrin VLA-4 subunit beta | |
| integrin beta 1 (fibronectin receptor beta) | |
| 4633401G24 | |
| beta (PAT-3) integrin | |
| beta i integrin | |
| beta(1A) integrin | |
| beta1 integrin | |
| beta1 integrin/PAT-3 | |
| beta-1 integrins | |
| Fibronectin receptor beta | |
| integrin beta 1 | |
| integrin beta 1 isoform 1A | |
| integrin beta 1 isoform 1B | |
| integrin beta 1 isoform 1C-1 | |
| integrin beta 1 isoform 1C-2 | |
| integrin beta 1 isoform 1D | |
| Integrin beta I | |
| integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | |
| Itgb I | |
| Itgb1 | |
| LOC143058 | |
| OTTHUMP00000019420 | |
| OTTHUMP00000046253 | |
| OTTHUMP00000063731 | |
| OTTHUMP00000063732 | |
| OTTHUMP00000063733 | |
| pat-3 (beta-integrin) | |
| VLA-4 beta | |
| VLA-4B | |
| VLA-4Bs | |
| integrin beta 1 isoform 1C-2 precursor | |
| integrin beta 1 isoform 1D precursor | |
| integrin beta 1 isoform 1C-1 precursor | |
| beta-1 integrin | |
| integrin beta 1 isoform 1A precursor | |
| RIKEN cDNA 4633401G24 gene | |
| integrin beta 1 isoform 1B precursor |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 135630 |
|---|
| Mouse chromosome position | 8 |
|---|---|
| 8 E2 |
| GO ID | 0046982 |
|---|---|
| 0004872 | |
| 0030183 | |
| 0007155 | |
| 0016477 | |
| 0033631 | |
| 0007160 | |
| 0006968 | |
| 0007156 | |
| 0007229 | |
| 0044419 | |
| 0007159 | |
| 0009986 | |
| 0005925 | |
| 0016021 | |
| 0008305 | |
| 0042470 | |
| 0031594 | |
| 0005886 | |
| 0001726 | |
| 0032587 | |
| 0042383 | |
| 0003779 | |
| 0051393 | |
| 0005518 | |
| 0001968 | |
| 0001948 | |
| 0005178 | |
| 0019900 | |
| 0043236 | |
| 0042277 | |
| 0002020 | |
| 0032403 | |
| 0019904 | |
| 0019901 | |
| 0005102 | |
| 0000082 | |
| 0055007 | |
| 0001708 | |
| 0006874 | |
| 0008354 | |
| 0001701 | |
| 0045596 | |
| 0031345 | |
| 0008285 | |
| 0045665 | |
| 0031175 | |
| 0043410 | |
| 0030335 | |
| 0008284 | |
| 0010811 | |
| 0045807 | |
| 0045666 | |
| 0010976 | |
| 0050731 | |
| 0032594 | |
| 0008277 | |
| 0051726 | |
| 0045214 | |
| 0070830 | |
| 0001894 | |
| 0001669 | |
| 0005912 | |
| 0034667 | |
| 0034679 | |
| 0005604 | |
| 0005911 | |
| 0030056 | |
| 0016020 | |
| 0005624 | |
| 0045121 | |
| 0019717 | |
| 0071479 | |
| 0071260 | |
| 0071445 | |
| 0071305 | |
| 0060135 | |
| 0014823 | |
| 0042493 | |
| 0034698 | |
| 0031667 | |
| 0071559 | |
| 0048812 | |
| 0042802 | |
| 0042685 | |
| 0010002 | |
| 0005488 | |
| 0005515 |
| Rat chromosome position | 19q12 |
|---|
| Swiss-Prot Accession | P05556 |
|---|---|
| Q5T3E4 | |
| Q5T3E5 | |
| Q5T3E6 | |
| P09055 | |
| Q60993 | |
| Q61126 | |
| Q8BUD1 | |
| Q8BY44 | |
| P49134 | |
| A8K6N2 | |
| P78466 | |
| P78467 | |
| Q13089 | |
| Q13090 | |
| Q13091 | |
| Q13212 | |
| Q14622 | |
| Q14647 | |
| Q29RW2 | |
| Q7Z3V1 | |
| Q8WUM6 | |
| A2RRT8 | |
| Q3TIW5 | |
| Q3TWH6 | |
| Q8BTU0 | |
| Q8BVU1 | |
| D3DRY5 | |
| D3DRX9 | |
| D3DRY4 | |
| D3DRY3 |
| PIR ID | B27079 |
|---|---|
| JC4126 | |
| PL0104 | |
| S01659 |
| Unigene ID | Hs.643813 |
|---|---|
| Mm.263396 | |
| Rn.25733 |
| KEGG ID | hsa:3688 |
|---|---|
| mmu:16412 | |
| rno:24511 |
| Swiss-Prot ID | ITB1_HUMAN |
|---|---|
| ITB1_RAT | |
| ITB1_MOUSE | |
| D3DRY5_HUMAN | |
| D3DRX9_HUMAN | |
| D3DRY4_HUMAN | |
| D3DRY3_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Melanosome | |
| Membrane | |
| Plasma membrane |
| IPI ID | IPI00217561 |
|---|---|
| IPI00217562 | |
| IPI00217563 | |
| IPI00293305 | |
| IPI00549336 | |
| IPI00191681 | |
| IPI00132474 | |
| IPI00645905 | |
| IPI00642219 | |
| IPI00226871 | |
| IPI00475101 | |
| IPI00568839 |
| Homologene ID | 22999 |
|---|
| RGD ID | 2927 |
|---|
| MGI ID | 96610 |
|---|