| URN | urn:agi-ProtModification:inout-urn:agi-llid:2534:out-urn:agi-llid:1600::unknown |
|---|---|
| References | 7 |
| Connectivity | 2 |
| Effect | unknown |
| TextRef | info:pmid/15361067#abs:7 |
|---|---|
| MedLine Reference | 15361067:6 |
| Sentence | When mDab1 is phosphorylated by Fyn kinase in COS-7 cells, mDab1 is ubiquitinated in a Cbl-dependent manner, and mDab1 does not induce filopodium in the presence of activated Fyn. |
| CellLineName | COS-7 |
| TextRef | info:pmid/16529723#abs:6 |
|---|---|
| MedLine Reference | 16529723:5 |
| Sentence | Cdk5 phosphorylates p80 Dab1 at multiple sites in its carboxyl-terminal region, and tyrosine phosphorylation of p80 Dab1 by Fyn tyrosine kinase is attenuated by this Cdk5-mediated phosphorylation in vitro. |
| Organ | Brain |
| Organism | Mus musculus |
| TextRef | info:pmid/19074029#abs:1 |
|---|---|
| MedLine Reference | 19074029:0 |
| Sentence | Reelin controls neuronal positioning in the developing brain by binding to the two lipoprotein receptors, very-low-density lipoprotein receptor and apolipoprotein E receptor 2, to stimulate phosphorylation of Disabled-1 (Dab1) by the Fyn and Src tyrosine kinases. |
| CellType | neural |
| Organ | Brain |
| TextRef | info:pmid/15175346#cont:257 |
|---|---|
| MedLine Reference | 15175346:10256 |
| Sentence | Finally, we sought to clarify the role of the Src family kinase Fyn, which phosphorylates Dab1 in vivo ( 2 , 3 ), in the Reelin-dependent Dab1 down-regulation. |
| Tissue | egg |
| CellType | neural |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i32 p33471 |
| Journal Link | http://www.jbc.org/cgi/content/full/279/32/33471 |
| TextRef | info:pmid/10827199#cont:230 |
|---|---|
| MedLine Reference | 10827199:10229 |
| Sentence | Fyn tyrosine phosphorylates Dab1 , which is bound to the NP X Y motif present on the intracellular domain of ApoER2 , and triggers activation of downstream components. |
| CellType | neural |
| Journal | J. Biol. Chem |
| Journal Reference | v275 i33 p25625 |
| Journal Link | http://www.jbc.org/cgi/content/full/275/33/25625 |
| TextRef | info:pmid/17698586#cont:22 |
|---|---|
| MedLine Reference | 17698586:10021 |
| Sentence | This triggers tyrosine phosphorylation of the intracellular adaptor Disabled-1 (Dab1) by kinases of the Src family, particularly Src and Fyn ( 4 , 9 , 43 , 46 ). |
| CellType | neural |
| Journal | Mol. Cell. Biol |
| Journal Reference | v27 i20 p7113 |
| Journal Link | http://mcb.asm.org/cgi/content/full/27/20/7113 |
| TextRef | info:pmid/10725376#cont:36 |
|---|---|
| MedLine Reference | 10725376:10035 |
| Sentence | Because Dab1 needs to be phosphorylated to participate in the Reln signaling pathway ( 17 ), it is possible that Reln, binding to an extracellular integrin receptor domain ( 8 , 12 ), not only promotes integrin receptor clustering, but also activates cytosolic Fyn kinase that in turn phosphorylates Dab1. |
| Tissue | cortex |
| CellType | neural |
| Journal | PNAS |
| Journal Reference | v97 i7 p3550 |
| Journal Link | http://www.pnas.org/cgi/content/full/97/7/3550 |