| URN | urn:agi-Regulation:inout-urn:agi-llid:4186:out-urn:agi-gocellproc:0001764::unknown |
|---|---|
| References | 61 |
| Connectivity | 2 |
| Effect | unknown |
| Original # of References | 30 |
| TextRef | info:pmid/11163259#abs:1 |
|---|---|
| PubYear | 2000 |
| MedlineTA | Neuron |
| MedLine Reference | 11163259:0 |
| Sentence | Mutations in mammalian Lis1 (Pafah1b1) result in neuronal migration defects. |
| TextRef | info:pmid/11056531#abs:2 |
|---|---|
| PubYear | 2000 |
| MedlineTA | Nat Cell Biol |
| MedLine Reference | 11056531:1 |
| Sentence | Reduced Lis1 activity in both humans and mice results in a neuronal migration defect. |
| TextRef | info:pmid/14578885#abs:5 |
|---|---|
| PubYear | 2003 |
| MedlineTA | Nat Genet |
| Organ | Hippocampus |
| MedLine Reference | 14578885:4 |
| Sentence | Lis1 associates with microtubules and modulates neuronal migration. |
| TextRef | info:pmid/12629176#abs:6 |
|---|---|
| PubYear | 2003 |
| MedlineTA | J Neurosci |
| MedLine Reference | 12629176:5 |
| Sentence | LIS1 dose-dependent defects in neuronal migration were found in vivo and in vitro. |
| CellType | Cajal-Retzius cells |
| TextRef | info:pmid/15473966#abs:3 |
|---|---|
| PubYear | 2004 |
| MedlineTA | Neuron |
| Organ | Brain |
| MedLine Reference | 15473966:2 |
| Sentence | However, the mechanism by which LIS1 regulates neuronal migration remains unknown. |
| CellType | Neurons |
| TextRef | info:pmid/16369480#abs:1 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Nat Neurosci |
| MedLine Reference | 16369480:0 |
| Sentence | Lis1 gene defects impair neuronal migration, causing the severe human brain malformation lissencephaly. |
| TextRef | info:pmid/10931877#abs:2 |
|---|---|
| PubYear | 2000 |
| MedlineTA | J Cell Biol |
| MedLine Reference | 10931877:1 |
| Sentence | NUDF protein, the product of the nudF gene, displays 42% sequence identity with the human protein LIS1 required for neuronal migration. |
| TextRef | info:pmid/12551946#abs:2 |
|---|---|
| PubYear | 2003 |
| MedlineTA | J Biol Chem |
| MedLine Reference | 12551946:1 |
| Sentence | LIS1 plays an important role in neuronal migration during brain development, but the in vivo function of the catalytic subunits remains unclear. |
| TextRef | info:pmid/16481446#abs:3 |
|---|---|
| PubYear | 2006 |
| MedlineTA | J Neurosci |
| Organ | Brain |
| MedLine Reference | 16481446:2 |
| Sentence | Substantial evidence indicates that Lis1 functions in a highly conserved pathway with dynein to regulate neuronal migration and other motile events. |
| CellType | Neurons |
| TextRef | info:pmid/12764037#abs:5 |
|---|---|
| PubYear | 2003 |
| MedlineTA | Cereb Cortex |
| Organ | Cerebral cortex |
| MedLine Reference | 12764037:4 |
| Sentence | The relationships between the LIS1 and Doublecortin proteins are not yet well defined, but both are believed to play a critical role in cortical neuronal migration. |
| TextRef | info:pmid/9384577#abs:11 |
|---|---|
| PubYear | 1997 |
| MedlineTA | EMBO J |
| Organ | Brain |
| MedLine Reference | 9384577:10 |
| Sentence | We postulate that the LIS1-cytoskeletal interaction is important for neuronal migration, a process that is defective in lissencephaly patients. |
| TextRef | info:pmid/9697693#abs:7 |
|---|---|
| PubYear | 1998 |
| MedlineTA | Nat Genet |
| Organ | Brain |
| MedLine Reference | 9697693:6 |
| Sentence | The phenotypes observed are distinct from those of other mouse mutants with neuronal migration defects, suggesting that Pafah1b1 participates in a novel pathway for neuronal migration. |
| CellType | Neurons |
| TextRef | info:pmid/20007476#abs:10 |
|---|---|
| PubYear | 2009 |
| MedlineTA | J Neurosci |
| Organ | Cerebral cortex |
| MedLine Reference | 20007476:9 |
| Sentence | Thus, Lis1 and Ndel1 are essential for normal cortical neuronal migration, neurite outgrowth, and function of the microtubule organizing center in a dose-dependent manner. |
| CellType | Neurons |
| TextMods | 114: 'MTOC ' -> 'microtubule organizing center ' |
| TextRef | info:pmid/10727864#abs:2 |
|---|---|
| PubYear | 2000 |
| MedlineTA | Mech Dev |
| MedLine Reference | 10727864:1 |
| Sentence | Miller-Dieker syndrome and isolated lissencephaly sequence patients have a hemizygous deletion or mutation in the LIS1 gene (PAFAH1B1), therefore, the LIS1 encoded protein (Lis1) may play a role in neuronal migration. |
| TextMods | 0: 'MDS ' -> 'Miller-Dieker syndrome ' 27: 'ILS ' -> 'isolated lissencephaly sequence ' |
| TextRef | info:pmid/7612965#abs:2 |
|---|---|
| PubYear | 1995 |
| MedlineTA | Mol Biol Cell |
| MedLine Reference | 7612965:1 |
| Sentence | The NUDF protein level is controlled by another protein NUDC, and extra copies of the nudF gene can suppress the nudC3 mutation. nudF encodes a protein with 42% sequence identity to the human LIS-1 (Miller-Dieker lissencephaly-1) gene, which is required for proper neuronal migration during brain development. |
| TextRef | info:pmid/17850624#abs:10 |
|---|---|
| PubYear | 2007 |
| MedlineTA | Clin Genet |
| MedLine Reference | 17850624:9 |
| Sentence | The identification of LIS1 as the first lissencephaly gene, and the first gene required for neuronal migration has revealed the importance of the regulation of cytoplasmic dynein in the control of neuronal migration by modulating nuclear migration in a pathway conserved in virtually all eukaryotes. |
| CellType | Fibroblasts |
| TextRef | info:pmid/15173193#body:90 |
|---|---|
| PubYear | 2004 |
| MedlineTA | J Cell Biol |
| MedLine Reference | 15173193:1089 |
| Sentence | These data suggest that neuronal migration can be positively regulated by Dcx or Lis1 expression. |
| CellType | Neurons |
| TextRef | info:pmid/14970193#body:24 |
|---|---|
| PubYear | 2004 |
| MedlineTA | J Cell Biol |
| MedLine Reference | 14970193:1023 |
| Sentence | Nudel and Lis1 appear to regulate cytoplasmic dynein in neuronal migration and mitosis through direct interactions. |
| TextRef | info:pmid/11163258#body:98 |
|---|---|
| PubYear | 2000 |
| MedlineTA | Neuron |
| Organ | Cerebral cortex |
| MedLine Reference | 11163258:1097 |
| Sentence | Given the many potential roles for LIS1, the mechanism by which LIS1 facilitates neuronal migration has remained unclear. |
| TextRef | info:pmid/15882636#body:112 |
|---|---|
| PubYear | 2005 |
| MedlineTA | Neuron |
| MedLine Reference | 15882636:1111 |
| Sentence | Disruptions of Lis1 result in a dose-dependent defect in neuronal migration that is probably a result of a defect in nucleokinesis. |
| CellType | Neurons |
| TextRef | info:pmid/20181597#body:334 |
|---|---|
| PubYear | 2010 |
| MedlineTA | J Neurosci |
| Organ | Cerebral cortex |
| MedLine Reference | 20181597:1333 |
| Sentence | These findings suggest that the molecular interaction of the LIS1 and DCX is important in both in neuronal migration and neurogenesis. |
| TextRef | info:pmid/11163254#body:148 |
|---|---|
| PubYear | 2000 |
| MedlineTA | Neuron |
| MedLine Reference | 11163254:1147 |
| Sentence | The prevailing model has been that while LIS1 and cdk5/p35 both play a role in neuronal migration, they do so via distinct and parallel pathways. |
| CellType | Neurons |
| TextRef | info:pmid/17600710#body:132 |
|---|---|
| PubYear | 2007 |
| MedlineTA | Curr Biol |
| MedLine Reference | 17600710:1131 |
| Sentence | Lis1, which is mutated in human lissencephaly, is involved in neuronal migration and neural stem cell division (reviewed in [12]). |
| TextRef | info:pmid/19927128#body:44 |
|---|---|
| PubYear | 2009 |
| MedlineTA | EMBO J |
| MedLine Reference | 19927128:1043 |
| Sentence | Deletions in the LIS1 gene result in a severe human neuronal migration deficit known as lissencephaly (Reiner et al, 1993; Lo Nigro et al, 1997; Pilz et al, 1998). |
| TextRef | info:pmid/11274050#body:161 |
|---|---|
| PubYear | 2001 |
| MedlineTA | Genes Dev |
| Organ | Nervous system |
| MedLine Reference | 11274050:1160 |
| Sentence | LIS1 is required for mammalian neuronal migration in a dosage-sensitive manner (Hirotsune et al. 1998) and for nuclear migration in A. nidulans. |
| CellType | Neurons |
| TextRef | info:pmid/12130536#body:125 |
|---|---|
| PubYear | 2002 |
| MedlineTA | Genes Dev |
| Organ | Cerebral cortex |
| MedLine Reference | 12130536:1124 |
| Sentence | CDK5, p35 (one of the CDK5 activator subunits), Lis1 (Pafah1b1), and Doublecortin are also thought to affect neuronal migration in the developing cortex. |
| TextRef | info:pmid/17494871#body:51 |
|---|---|
| PubYear | 2007 |
| MedlineTA | Mol Biol Cell |
| MedLine Reference | 17494871:1050 |
| Sentence | Mammalian NudE/NudE-like (Nudel) and Lis1 are originally proposed to regulate dynein in neuronal migration (Wynshaw-Boris and Gambello, 2001[Go]) but seem widely involved in dynein functions. |
| TextRef | info:pmid/16107726#body:187 |
|---|---|
| PubYear | 2005 |
| MedlineTA | Mol Cell Biol |
| Organ | Marginal Zone |
| MedLine Reference | 16107726:1186 |
| Sentence | Consistent with the biochemical interaction of LIS1 and NDEL1 (36), these developmental studies further suggest that Lis1 and Ndel1 genetically interact and synergistically regulate neuronal migration. |
| TextRef | info:pmid/16387639#body:54 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Neuron |
| MedLine Reference | 16387639:1053 |
| Sentence | Mutation in DCX (des Portes et al., 1998 and Gleeson et al., 1998), LIS1 (Reiner et al., 1993), Map1/2 family members (Takei et al., 2000), and KIF2A (Homma et al., 2003) among others lead to disordered neuronal migration in a variety of organisms. |
| CellType | Neurons |
| TextRef | info:pmid/15473967#body:304 |
|---|---|
| PubYear | 2004 |
| MedlineTA | Neuron |
| Organ | Cerebral cortex |
| MedLine Reference | 15473967:1303 |
| Sentence | While LIS1 has been known to be required for cortical neuronal migration, the molecular function of LIS1 has been of intense interest and controversy (Faulkner et al. 2000; Hattori et al. 1995; Liu et al. 2000; Niethammer et al. 2000; Reiner et al. 1993 and Sapir et al. 1997). |
| CellType | Neurons |
| TextRef | info:pmid/12796778#abs:2 |
|---|---|
| MedLine Reference | 12796778:1 |
| Sentence | Mutations in PAFAH1B1 (the gene encoding LIS1) are responsible for ILS and contribute to MDS, but the genetic causes of the greater severity of MDS are unknown. |
| CellLineName | MDS |
| TextRef | info:pmid/17314247#cont:358 |
|---|---|
| MedLine Reference | 17314247:10357 |
| Sentence | Graded reduction of Pafah1b (Lis1) activity results in neuronal migration defects and early embryonic lethality. |
| Journal | Cell Sci |
| Journal Reference | v120 i5 p858 |
| Journal Link | http://jcs.biologists.org/cgi/content/full/120/5/858 |
| TextRef | info:pmid/14744934#cont:414 |
|---|---|
| MedLine Reference | 14744934:10413 |
| Sentence | Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. |
| Journal | Genes & Dev |
| Journal Reference | v18 i3 p320 |
| Journal Link | http://www.genesdev.org/cgi/content/full/18/3/320 |
| TextRef | info:pmid/18347064#cont:533 |
|---|---|
| MedLine Reference | 18347064:10532 |
| Sentence | Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. |
| Journal | J. Cell Biol |
| Journal Reference | v180 i6 p1133 |
| Journal Link | http://jcb.rupress.org/cgi/content/full/180/6/1133 |
| TextRef | info:pmid/16157697#cont:210 |
|---|---|
| MedLine Reference | 16157697:10209 |
| Sentence | Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. |
| Journal | J. Cell Biol |
| Journal Reference | v170 i6 p867 |
| Journal Link | http://www.jcb.org/cgi/content/full/170/6/867 |
| TextRef | info:pmid/16144905#cont:480 |
|---|---|
| MedLine Reference | 16144905:10479 |
| Sentence | Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. |
| Journal | J. Cell Biol |
| Journal Reference | v170 i6 p935 |
| Journal Link | http://www.jcb.org/cgi/content/full/170/6/935 |
| TextRef | info:pmid/17698586#cont:702 |
|---|---|
| MedLine Reference | 17698586:10701 |
| Sentence | Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. |
| Journal | Mol. Cell. Biol |
| Journal Reference | v27 i20 p7113 |
| Journal Link | http://mcb.asm.org/cgi/content/full/27/20/7113 |
| TextRef | info:pmid/16107726#cont:460 |
|---|---|
| MedLine Reference | 16107726:10459 |
| Sentence | Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. |
| Journal | Mol. Cell. Biol |
| Journal Reference | v25 i17 p7812 |
| Journal Link | http://mcb.asm.org/cgi/content/full/25/17/7812 |
| TextRef | info:pmid/17682047#cont:414 |
|---|---|
| MedLine Reference | 17682047:10413 |
| Sentence | Graded reduction of Pafah1b1 ( Lis1 ) activity results in neuronal migration defects and early embryonic lethality. |
| Journal | J. Cell Biol |
| Journal Reference | v178 i4 p583 |
| Journal Link | http://jcb.rupress.org/cgi/content/full/178/4/583 |
| TextRef | info:pmid/17600710#cont:42 |
|---|---|
| Organ | Brain |
| MedLine Reference | 17600710:10041 |
| Sentence | However, the mechanism by which LIS1 regulates neuronal migration remains unknown. |
| CellType | neural |
| Organism | Homo sapiens |
| Tissue | cortex |
| TextRef | info:pmid/16751177#cont:390 |
|---|---|
| Organ | Brain |
| MedLine Reference | 16751177:10389 |
| Sentence | Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. |
| CellType | platelet |
| Journal | Genes & Dev |
| Journal Reference | v20 i11 p1384 |
| Journal Link | http://www.genesdev.org/cgi/content/full/20/11/1384 |
| TextRef | info:pmid/16449660#cont:740 |
|---|---|
| MedLine Reference | 16449660:10739 |
| Sentence | NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration. |
| Journal | Mol. Cell. Biol |
| Journal Reference | v26 i4 p1510 |
| Journal Link | http://mcb.asm.org/cgi/content/full/26/4/1510 |
| TextRef | info:pmid/15800059#cont:618 |
|---|---|
| MedLine Reference | 15800059:10617 |
| Sentence | NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration. |
| Journal | Mol. Biol. Cell |
| Journal Reference | v16 i6 p2759 |
| Journal Link | http://www.molbiolcell.org/cgi/content/full/16/6/2759 |
| TextRef | info:pmid/16467375#cont:879 |
|---|---|
| MedLine Reference | 16467375:10878 |
| Sentence | NudF, a nuclear migration gene in Aspergillus nidulans , is similar to the human LIS-1 gene required for neuronal migration. |
| Journal | Mol. Biol. Cell |
| Journal Reference | v17 i4 p2021 |
| Journal Link | http://www.molbiolcell.org/cgi/content/full/17/4/2021 |
| TextRef | info:pmid/11159375#cont:352 |
|---|---|
| Organ | Brain |
| MedLine Reference | 11159375:10351 |
| Sentence | Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality [see comments]. |
| CellType | platelet |
| Journal | Biology of reproduction |
| Journal Reference | v64 i2 p696 |
| Journal Link | http://www.biolreprod.org/cgi/content/full/64/2/696 |
| TextRef | info:pmid/11274050#cont:171 |
|---|---|
| Organ | Nervous system |
| MedLine Reference | 11274050:10170 |
| Sentence | LIS1 is required for mammalian neuronal migration in a dosage-sensitive manner (Hirotsune et al. 1998 ) and for nuclear migration in A. nidulans . |
| CellType | neural |
| Journal | Genes & Dev |
| Journal Reference | v15 i6 p639 |
| Journal Link | http://www.genesdev.org/cgi/content/full/15/6/639 |
| TextRef | info:pmid/12130536#cont:89 |
|---|---|
| MedLine Reference | 12130536:10088 |
| Sentence | CDK5, p35 (one of the CDK5 activator subunits), Lis1 (Pafah1b1), and Doublecortin are also thought to affect neuronal migration in the developing cortex. |
| Tissue | cortex |
| Journal | Genes & Dev |
| Journal Reference | v16 i14 p1760 |
| Journal Link | http://www.genesdev.org/cgi/content/full/16/14/1760 |
| TextRef | info:pmid/12629176#cont:22 |
|---|---|
| MedLine Reference | 12629176:10021 |
| Sentence | It is unknown whether the enzymatic function of LIS1 is important for neuronal migration, although several neuron-specific effects of PAF have been demonstrated (Hattori et al., 1996 ; Adachi et al., 1997 ; Bix and Clark, 1998 ). |
| CellType | neural |
| Journal | J. Neurosci |
| Journal Reference | v23 i5 p1719 |
| Journal Link | http://www.jneurosci.org/cgi/content/full/23/5/1719 |
| TextRef | info:pmid/11734602#cont:170 |
|---|---|
| MedLine Reference | 11734602:10169 |
| Sentence | Our findings therefore offer new insights into the molecular functions of NudC and provide a framework from which to test the function of NudC as a novel component of the Lis1/dynein motor complex involved in neurogenesis, neuronal migration, and brain development. |
| CellType | neural |
| Tissue | cortex |
| Journal | J. Neurosci |
| Journal Reference | v21 i24 pRC187 |
| Journal Link | http://www.jneurosci.org/cgi/content/full/21/24/RC187 |
| Organ | Nervous system |
|---|---|
| MedLine Reference | 164101385:10059 |
| Sentence | Abstract Mutations in mammalian Lis1 ( Pafah1b1 ) result in neuronal migration defects. |
| Journal | Neuron |
| Journal Reference | v28 i3 p8 |
| Journal Link | http://www.neuron.org/content/article/fulltext?uid=PIIS089662730000146X |
| MedLine Reference | 110003406:10070 |
|---|---|
| Sentence | These data suggest that neuronal migration can be positively regulated by Dcx or Lis1 expression. |
| CellType | neural |
| Journal | J. Cell Biol |
| Journal Reference | v165 i5 p709 |
| Journal Link | http://www.jcb.org/cgi/content/full/165/5/709 |
| Organ | telencephalon |
|---|---|
| MedLine Reference | 164103001:10304 |
| Sentence | Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. |
| Journal | Neuron |
| Journal Reference | v44 i2 p10 |
| Journal Link | http://www.neuron.org/content/article/fulltext?uid=PIIS0896627304006324 |
| MedLine Reference | 164103002:10294 |
|---|---|
| Sentence | Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. |
| CellType | neural |
| Journal | Neuron |
| Journal Reference | v44 i2 p11 |
| Journal Link | http://www.neuron.org/content/article/fulltext?uid=PIIS0896627304006117 |
| Organ | Brain |
|---|---|
| MedLine Reference | 164101384:10025 |
| Sentence | However, the mechanism by which LIS1 regulates neuronal migration remains unknown. |
| CellType | neural |
| Organism | Homo sapiens |
| Tissue | cortex |
| Journal | Neuron |
| Journal Reference | v28 i3 p7 |
| Journal Link | http://www.neuron.org/content/article/fulltext?uid=PIIS0896627300001458 |
| MedLine Reference | 164102705:10394 |
|---|---|
| Sentence | Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. |
| CellType | neural |
| Tissue | astroglia |
| Journal | Neuron |
| Journal Reference | v41 i2 p7 |
| Journal Link | http://www.neuron.org/content/article/fulltext?uid=PIIS0896627303008523 |
| MedLine Reference | 164101380:10041 |
|---|---|
| Sentence | Thus, LIS1-mNudE interactions may regulate neuronal migration through dynamic reorganization of the MTOC. |
| Organism | Xenopus laevis |
| Tissue | egg |
| Journal | Neuron |
| Journal Reference | v28 i3 p3 |
| Journal Link | http://www.neuron.org/content/article/fulltext?uid=PIIS0896627300001422 |
| MedLine Reference | 164101386:10046 |
|---|---|
| Sentence | Thus, LIS1-mNudE interactions may regulate neuronal migration through dynamic reorganization of the MTOC. |
| Organism | Xenopus laevis |
| Tissue | egg |
| Journal | Neuron |
| Journal Reference | v28 i3 p9 |
| Journal Link | http://www.neuron.org/content/article/fulltext?uid=PIIS0896627300001471 |
| MedLine Reference | 164100889:10981 |
|---|---|
| Sentence | Morris, NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration. |
| Journal | Neuron |
| Journal Reference | v23 i1 p6 |
| Journal Link | http://www.neuron.org/content/article/fulltext?uid=PIIS0896627300807497 |
| MedLine Reference | 110100513:10004 |
|---|---|
| Sentence | As neuronal positioning is disrupted by this disease, LIS1 and dynein are assumed to be involved in neuronal migration. |
| CellType | neural |
| Journal | J. Cell Biol |
| Journal Reference | v170 i6 p860 |
| Journal Link | http://www.jcb.org/cgi/content/full/170/6/860 |
| MedLine Reference | 164100916:10434 |
|---|---|
| Sentence | X Xiang, A.H Osmani, S.A Osmani, M Xin and N.R Morris, NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration. |
| Journal | Neuron |
| Journal Reference | v23 i2 p11 |
| Journal Link | http://www.neuron.org/content/article/fulltext?uid=PIIS0896627300807783 |
| MedLine Reference | 162101336:10049 |
|---|---|
| Sentence | X Xiang, AH Osmani, SA Osmani, M Xin and NR Morris, NudF , a nuclear migration gene in Aspergillus nidulans , is similar to the human LIS-1 gene required for neuronal migration. |
| CellType | t cell |
| Journal | Current Biology |
| Journal Reference | v8 i10 p22 |
| Journal Link | http://www.current-biology.com/content/article/fulltext?uid=PIIS0960982298702325 |