| URN | urn:agi-Regulation:inout-urn:agi-llid:4186:out-urn:agi-gocellproc:0007420::unknown |
|---|---|
| References | 6 |
| Connectivity | 2 |
| Effect | unknown |
| Original # of References | 4 |
| TextRef | info:pmid/12551946#abs:2 |
|---|---|
| PubYear | 2003 |
| MedlineTA | J Biol Chem |
| MedLine Reference | 12551946:1 |
| Sentence | LIS1 plays an important role in neuronal migration during brain development, but the in vivo function of the catalytic subunits remains unclear. |
| TextRef | info:pmid/17286146#abs:5 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Hum Exp Toxicol |
| MedLine Reference | 17286146:4 |
| Sentence | Down-regulation of two genes, FGD1 and PAFAH1B1, related in that both are essential for fetal brain development, was corroborated using quantitative real time PCR. |
| Organism | Homo sapiens |
| CellLineName | MCF7 |
| TextRef | info:pmid/11231056#abs:1 |
|---|---|
| PubYear | 2001 |
| MedlineTA | Mech Dev |
| MedLine Reference | 11231056:0 |
| Sentence | The LIS1-encoded protein (Lis1) plays a role in brain development because a hemizygous deletion or mutation of the human gene causes neuronal migration disorders, such as Miller-Dieker syndrome or isolated lissencephaly sequence . |
| TextMods | 194: '(MDS) ' -> '' 229: '(ILS)' -> '' |
| TextRef | info:pmid/17984054#body:166 |
|---|---|
| PubYear | 2007 |
| MedlineTA | Proc Natl Acad Sci U S A |
| MedLine Reference | 17984054:1165 |
| Sentence | In the absence of a known functional target, we sought to model disruption of DISC1 in relation to the functional complexes it forms with Nudel and Lis1, genes that regulate several aspects of brain development and that bind with the C terminus region of DISC1 (16-18, 20, 21), the region that is altered by the (1;11)(q42.1;q14.3) translocation (6). |
| TextRef | info:pmid/19657569#abs:3 |
|---|---|
| MedLine Reference | 19657569:2 |
| Sentence | Mutation or deletion of LIS1 leads to proliferation and migration deficiency of neurons in brain development. |
| CellType | neural |
| TextRef | info:pmid/11734602#cont:170 |
|---|---|
| MedLine Reference | 11734602:10169 |
| Sentence | Our findings therefore offer new insights into the molecular functions of NudC and provide a framework from which to test the function of NudC as a novel component of the Lis1/dynein motor complex involved in neurogenesis, neuronal migration, and brain development. |
| CellType | neural |
| Tissue | cortex |
| Journal | J. Neurosci |
| Journal Reference | v21 i24 pRC187 |
| Journal Link | http://www.jneurosci.org/cgi/content/full/21/24/RC187 |