Ariadne Genomics Inc. Src-related kinases --+> Grin2b Src-related kinases --+> Grin2a Src-related kinases Itga3 ---> integrin mediated signaling pathway P-tyrosine PAFAH1B3 PAFAH1B1 Dab1 ---- Vldlr Ca2+ ---> Gria1 phosphatidylinositol 3-kinase-Akt signaling pathway Grin2b ---- Vldlr Grin2a ---- Lrp8 Grin2a ---- Vldlr Grin2b ---- Lrp8 thyroid hormones Dab1 ---- Lrp8 Itgb1 ---- Reln Itga3 ---- Reln Reln ---- Vldlr Lrp8 ---- Reln Dab1 ---- PtdIns4P PAFAH1B1 ---> brain development PAFAH1B1 ---> neuronal migration Itgb1 ---> integrin mediated signaling pathway brain development Pik3r1 Ca2+ ---> learning and/or memory learning and/or memory neuronal migration PtdIns4P Reln Gria1 Grin2a Grin2b Lrp8 Vldlr Itga3 Itgb1 Pafah1b2 Grin2a --+> Ca2+ Grin2b --+> Ca2+ Itgb1 --+> Dab1 Itga3 --+> Dab1 Dab1 Dab1 --+> Src-related kinases Pik3r1 ---> phosphatidylinositol 3-kinase-Akt signaling pathway Fyn --+> Dab1 Fyn Dab1 --+> Fyn Src-related kinases --+> Dab1 integrin mediated signaling pathway Gria1 --+> synaptic transmission synaptic transmission thyroid hormones --+> Reln Pafah1b2 ---- Vldlr PAFAH1B3 ---- Vldlr Dab1 ---- PAFAH1B1 Dab1 ---- Gria1 Ca2+