| URN | urn:agi-llid:8945 |
|---|---|
| Total Entities | 0 |
| Connectivity | 535 |
| Name | Btrc |
| Description | beta-transducin repeat containing |
| Notes | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway. |
| GO Molecular Function | ubiquitin-protein ligase activity |
|---|---|
| beta-catenin binding | |
| protein phosphorylated amino acid binding |
| GO Cellular Component | SCF ubiquitin ligase complex |
|---|---|
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | branching involved in mammary gland duct morphogenesis |
|---|---|
| mammary gland epithelial cell proliferation | |
| regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | |
| positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | |
| regulation of cell cycle | |
| mitotic cell cycle | |
| signal transduction | |
| regulation of I-kappaB kinase-NF-kappaB signaling | |
| negative regulation of smoothened signaling pathway | |
| Wnt signaling pathway | |
| cellular response to organic cyclic compound | |
| positive regulation of circadian rhythm | |
| positive regulation of transcription, DNA-templated | |
| positive regulation of proteolysis | |
| regulation of proteasomal protein catabolic process | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of sequence-specific DNA binding transcription factor activity | |
| protein destabilization | |
| protein dephosphorylation | |
| protein ubiquitination | |
| protein polyubiquitination | |
| ubiquitin-dependent protein catabolic process | |
| anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | |
| protein catabolic process | |
| viral process | |
| modulation by virus of host morphology or physiology |
| Pathway | Cell Cycle |
|---|---|
| Breast Cancer Related to WNT Signaling Pathway | |
| Wnt signaling, canonical pathway | |
| Wnt signaling, canonical pathway | |
| altered Wnt signaling, canonical pathway | |
| canonical Wnt signaling pathway | |
| altered canonical Wnt signaling pathway | |
| canonical Wnt signaling pathway | |
| altered canonical Wnt signaling pathway | |
| nuclear factor, erythroid 2 like 2 signaling pathway | |
| nuclear factor-erythoid 2 like 2 signaling pathway |
| Group | branching involved in mammary gland duct morphogenesis |
|---|---|
| mammary gland epithelial cell proliferation | |
| regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | |
| positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | |
| regulation of cell cycle | |
| mitotic cell cycle | |
| signal transduction | |
| regulation of I-kappaB kinase-NF-kappaB signaling | |
| negative regulation of smoothened signaling pathway | |
| Wnt signaling pathway | |
| cellular response to organic cyclic compound | |
| positive regulation of circadian rhythm | |
| positive regulation of transcription, DNA-templated | |
| positive regulation of proteolysis | |
| regulation of proteasomal protein catabolic process | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of sequence-specific DNA binding transcription factor activity | |
| protein destabilization | |
| ubiquitin-protein ligase activity | |
| protein dephosphorylation | |
| protein ubiquitination | |
| protein polyubiquitination | |
| ubiquitin-dependent protein catabolic process | |
| anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | |
| protein catabolic process | |
| viral process | |
| modulation by virus of host morphology or physiology | |
| beta-catenin binding | |
| protein phosphorylated amino acid binding | |
| SCF ubiquitin ligase complex | |
| cytoplasm | |
| cytosol | |
| nucleus |
| LocusLink ID | 8945 |
|---|---|
| 12234 | |
| 361765 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Endoplasmic reticulum |
| GO ID | 0008013 |
|---|---|
| 0045309 | |
| 0004842 | |
| 0016055 | |
| 0031145 | |
| 0060444 | |
| 0071407 | |
| 0033598 | |
| 0000278 | |
| 0019048 | |
| 0043433 | |
| 0045879 | |
| 0045892 | |
| 0042753 | |
| 0045862 | |
| 0045893 | |
| 0051437 | |
| 0006470 | |
| 0031648 | |
| 0000209 | |
| 0016567 | |
| 0043122 | |
| 0051726 | |
| 0061136 | |
| 0051439 | |
| 0007165 | |
| 0006511 | |
| 0016032 | |
| 0019005 | |
| 0005829 | |
| 0005634 | |
| 0030163 | |
| 0005737 | |
| 0016874 | |
| 0044419 | |
| 0005515 | |
| 0006512 | |
| 0005783 | |
| 0006464 | |
| 0004840 |
| Alias | FWD1 |
|---|---|
| FBW1A | |
| FBXW1 | |
| bTrCP | |
| FBXW1A | |
| bTrCP1 | |
| betaTrCP | |
| BETA-TRCP | |
| RP11-529I10.2 | |
| F-box/WD repeat-containing protein 1A | |
| beta-TrCP1 | |
| E3RSIkappaB | |
| F-box and WD-repeat protein 1B | |
| epididymis tissue protein Li 2a | |
| pIkappaBalpha-E3 receptor subunit | |
| F-box and WD repeats protein beta-TrCP | |
| HOS | |
| Slimb | |
| b-TrCP | |
| E3RS-IkappaB | |
| SCF b-TRCP | |
| mE3RS-IkappaB | |
| ubiquitin ligase FWD1 | |
| pIkappaB-E3 receptor subunit | |
| beta-TrCP protein E3RS-IkappaB | |
| beta-transducin repeat containing protein | |
| Kiaa4123 | |
| mKIAA4123 | |
| beta-transducin repeat containing E3 ubiquitin protein ligase | |
| pI kappa B alpha-E3 receptor subunit | |
| OTTHUMP00000020315 | |
| mSlimb | |
| beta transducin repeat containing proteins | |
| OTTHUMP00000020314 | |
| beta-transducin repeat containing | |
| MGC4643 | |
| BTRC | |
| MGC105884 | |
| Beta transducin repeats containing protein | |
| E3RSI kappa B | |
| FWD I | |
| F-box and WD-repeats protein beta-TrCP | |
| beta-transducin repeat-containing protein | |
| hypothetical protein MGC4643 |
| Mouse chromosome position | 19 |
|---|---|
| 19 D1 |
| OMIM ID | 603482 |
|---|
| Rat chromosome position | 1q54 |
|---|
| Hugo ID | 1144 |
|---|
| Human chromosome position | 10q24.32 |
|---|
| Swiss-Prot Accession | B2R8L3 |
|---|---|
| B7Z3H4 | |
| Q68DS0 | |
| Q9Y297 | |
| Q3ULA2 | |
| Q5U4E5 | |
| B5MD49 | |
| Q5W141 | |
| Q5W142 | |
| Q9Y213 | |
| Q3U0Q4 | |
| Q571K6 | |
| Q9QUI5 | |
| Q9R1G7 | |
| Q9Z159 | |
| Q5T1W7 | |
| Q86WI5 |
| Unigene ID | Hs.643802 |
|---|---|
| Mm.119717 | |
| Mm.446448 | |
| Rn.21800 | |
| Hs.713753 | |
| Hs.696242 | |
| Hs.500812 |
| KEGG ID | hsa:8945 |
|---|---|
| mmu:12234 | |
| rno:361765 |
| Swiss-Prot ID | FBW1A_HUMAN |
|---|---|
| FBW1A_MOUSE | |
| Q5W141_HUMAN | |
| Q5U4E5_RAT | |
| Q5W142_HUMAN | |
| Q3ULA2_MOUSE | |
| Q9QUI5_MOUSE |
| Ensembl ID | ENSG00000166167 |
|---|---|
| ENSP00000377088 | |
| ENST00000393441 | |
| ENSP00000385339 | |
| ENST00000408038 | |
| ENSP00000359206 | |
| ENST00000370187 | |
| ENSMUSG00000025217 | |
| ENSMUSP00000070728 | |
| ENSMUST00000065601 | |
| ENSMUSP00000107567 | |
| ENSMUST00000111936 | |
| ENSRNOG00000016280 | |
| ENSRNOP00000022426 | |
| ENSRNOT00000022426 |
| Homologene ID | 39330 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1338871 |
|---|
| RGD ID | 1359721 |
|---|
| MedScan ID | 8945 |
|---|
| IPI ID | IPI00307418 |
|---|---|
| IPI00413142 | |
| IPI00402788 | |
| IPI00877195 | |
| IPI00951294 | |
| IPI00903156 | |
| IPI00470930 | |
| IPI00641852 | |
| IPI00620670 | |
| IPI00372531 |