| URN | urn:agi-llid:8202 |
|---|---|
| Total Entities | 0 |
| Connectivity | 829 |
| Name | Ncoa3 |
| Description | nuclear receptor coactivator 3 |
| Notes | The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010] |
| GO Molecular Function | histone acetyltransferase activity |
|---|---|
| signal transducer activity | |
| transcription coactivator activity | |
| ligand-dependent nuclear receptor transcription coactivator activity | |
| transferase activity | |
| transferase activity, transferring acyl groups | |
| chromatin binding | |
| protein complex binding | |
| protein N-terminus binding | |
| thyroid hormone receptor binding | |
| peroxisome proliferator activated receptor binding | |
| ligand-dependent nuclear receptor binding | |
| nuclear hormone receptor binding | |
| estrogen receptor binding | |
| androgen receptor binding | |
| DNA binding | |
| RNA polymerase II regulatory region DNA binding |
| GO Cellular Component | nucleolus |
|---|---|
| cytoplasm | |
| Golgi apparatus | |
| perinuclear region of cytoplasm | |
| nucleus |
| GO Biological Process | mammary gland branching involved in thelarche |
|---|---|
| male gonad development | |
| vagina development | |
| histone acetylation | |
| multicellular organism growth | |
| labyrinthine layer morphogenesis | |
| positive regulation of keratinocyte differentiation | |
| developmental growth | |
| signal transduction | |
| positive regulation of intracellular steroid hormone receptor signaling pathway | |
| positive regulation of intracellular estrogen receptor signaling pathway | |
| receptor transactivation | |
| androgen receptor signaling pathway | |
| positive regulation of cell growth | |
| negative regulation of apoptotic process | |
| positive regulation of transcription, DNA-templated | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene expression | |
| regulation of RNA biosynthetic process | |
| regulation of transcription, DNA-templated | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| transcription, DNA-templated |
| Pathway | Histone Acetylation |
|---|---|
| Androgen Receptor to Akt Signaling in Prostate Cancer | |
| Prostate Cancer Overview | |
| Hereditary Breast and Ovarian Cancer Syndrome | |
| Breast Cancer Related to ESR1 Signaling Pathway | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to ESR1 Signaling Pathway | |
| ESR1/ERBB-positive Luminal Breast Cancer | |
| Common Genomic Effects of Thyroid Hormones | |
| Clear Cell Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Clear Cell Ovarian Carcinoma | |
| Mucinous Ovarian Carcinoma | |
| High-grade Serous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Mucinous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of High-grade Serous Ovarian Carcinoma | |
| Endometrioid Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Endometrioid Ovarian Carcinoma | |
| Ovarian Cancer Overview | |
| Low-grade Serous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Low-grade Serous Ovarian Carcinoma | |
| Type I Endometrial Cancer (Endometrioid Endometrial Cancer) | |
| Type II Endometrial Cancer (Clear-cell Endometrial Cancer and Papillary Serous Endometrial Cancer) | |
| Endometrial Cancer Overview | |
| Proteins Involved in Pathogenesis of Prostate Cancer | |
| Proteins Involved in Pathogenesis of Polycystic Ovary Syndrome | |
| Proteins Involved in Pathogenesis of Hepatocellular Carcinoma | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/STAT Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| nuclear factor, erythroid 2 like 2 signaling pathway |
| Group | PAS domain |
|---|---|
| Chromatin remodeling | |
| mammary gland branching involved in thelarche | |
| male gonad development | |
| vagina development | |
| histone acetylation | |
| histone acetyltransferase activity | |
| multicellular organism growth | |
| labyrinthine layer morphogenesis | |
| positive regulation of keratinocyte differentiation | |
| developmental growth | |
| signal transduction | |
| signal transducer activity | |
| positive regulation of intracellular steroid hormone receptor signaling pathway | |
| positive regulation of intracellular estrogen receptor signaling pathway | |
| receptor transactivation | |
| androgen receptor signaling pathway | |
| positive regulation of cell growth | |
| negative regulation of apoptotic process | |
| positive regulation of transcription, DNA-templated | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene expression | |
| regulation of RNA biosynthetic process | |
| regulation of transcription, DNA-templated | |
| transcription coactivator activity | |
| ligand-dependent nuclear receptor transcription coactivator activity | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| transferase activity | |
| transferase activity, transferring acyl groups | |
| transcription, DNA-templated | |
| chromatin binding | |
| protein complex binding | |
| protein N-terminus binding | |
| thyroid hormone receptor binding | |
| peroxisome proliferator activated receptor binding | |
| ligand-dependent nuclear receptor binding | |
| nuclear hormone receptor binding | |
| estrogen receptor binding | |
| androgen receptor binding | |
| DNA binding | |
| RNA polymerase II regulatory region DNA binding | |
| nucleolus | |
| cytoplasm | |
| Golgi apparatus | |
| perinuclear region of cytoplasm | |
| nucleus | |
| Proteins Involved in Pathogenesis of Hereditary Breast and Ovarian Cancer Syndrome |
| LocusLink ID | 8202 |
|---|---|
| 17979 | |
| 84584 |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| GO ID | 0050681 |
|---|---|
| 0003682 | |
| 0004402 | |
| 0016922 | |
| 0035257 | |
| 0047485 | |
| 0004871 | |
| 0046966 | |
| 0003713 | |
| 0030521 | |
| 0048589 | |
| 0016573 | |
| 0060744 | |
| 0035264 | |
| 0010628 | |
| 0045618 | |
| 0045944 | |
| 0045893 | |
| 0035624 | |
| 2001141 | |
| 0006351 | |
| 0060068 | |
| 0005737 | |
| 0005730 | |
| 0005634 | |
| 0003677 | |
| 0001012 | |
| 0030331 | |
| 0030374 | |
| 0042975 | |
| 0032403 | |
| 0016740 | |
| 0016746 | |
| 0060713 | |
| 0043066 | |
| 0030307 | |
| 0033148 | |
| 0033145 | |
| 0051091 | |
| 0006355 | |
| 0007165 | |
| 0005794 | |
| 0048471 | |
| 0008584 |
| Alias | ACTR |
|---|---|
| AIB1 | |
| RAC3 | |
| SRC3 | |
| pCIP | |
| AIB-1 | |
| CTG26 | |
| SRC-3 | |
| CAGH16 | |
| KAT13B | |
| TNRC14 | |
| TNRC16 | |
| TRAM-1 | |
| bHLHe42 | |
| RP5-1049G16.3 | |
| nuclear receptor coactivator 3 | |
| CBP-interacting protein | |
| receptor-associated coactivator 3 | |
| amplified in breast cancer 1 protein | |
| steroid receptor coactivator protein 3 | |
| class E basic helix-loop-helix protein 42 | |
| thyroid hormone receptor activator molecule 1 | |
| Tram1 | |
| p/Cip | |
| AW321064 | |
| 2010305B15Rik | |
| RP23-120P1.1 | |
| RAC-3 | |
| NCoA-3 | |
| amplified in breast cancer-1 protein homolog | |
| SRC-3/AIB1 | |
| steroid receptor coactivator AIB1 | |
| OTTMUSP00000001104 | |
| RAC3/SRC-3 | |
| receptor-associated coactivator III | |
| SRC-3/RAC3 | |
| steroid hormone receptor coactivator (SRC) 3 | |
| steroid receptor coactivator protein III | |
| TRAM I | |
| OTTHUMP00000031718 | |
| nuclear receptor coactivator amplified in breast cancer 1 | |
| nuclear receptor coactivator AIB I | |
| RIKEN cDNA 2010305B15 gene | |
| amplified in breast cancer-1 | |
| 2010305B15 | |
| AIB I | |
| nuclear receptor coactivator III | |
| amplified in breast cancer I | |
| OTTHUMP00000031716 | |
| CBP interacting protein | |
| amplified in breast cancer 1 | |
| nuclear receptor coactivator AIB1 | |
| nuclear receptor co-activator RAC3 | |
| nuclear receptor coactivator (N-CoA) 3 | |
| N-CoA3 | |
| NCOA3 | |
| MGC141848 | |
| LOC296375 |
| Mouse chromosome position | 2 |
|---|
| OMIM ID | 601937 |
|---|
| Rat chromosome position | 3q42 |
|---|
| Hugo ID | 7670 |
|---|
| Human chromosome position | 20q12 |
|---|
| Swiss-Prot Accession | Q59EE8 |
|---|---|
| Q9Y6Q9 | |
| Q0IIN7 | |
| A5D6Q2 | |
| Q05BA5 | |
| O09000 | |
| Q9EPU2 | |
| A4LAZ5 | |
| Q0VF45 | |
| Q5JYD9 | |
| Q5JYE0 | |
| Q9BR49 | |
| Q9UPC9 | |
| Q9UPG4 | |
| Q9UPG7 |
| PIR ID | T03851 |
|---|
| Unigene ID | Hs.592142 |
|---|---|
| Mm.469663 | |
| Rn.20691 |
| KEGG ID | hsa:8202 |
|---|---|
| mmu:17979 | |
| rno:84584 |
| Swiss-Prot ID | NCOA3_HUMAN |
|---|
| EC Number | 2.3.1.48 |
|---|
| Ensembl ID | ENSG00000124151 |
|---|---|
| ENSP00000361065 | |
| ENST00000371997 | |
| ENSP00000361073 | |
| ENST00000372004 | |
| ENSMUSG00000027678 | |
| ENSMUSP00000085416 | |
| ENSMUST00000088095 | |
| ENSRNOG00000005616 | |
| ENSRNOP00000007768 | |
| ENSRNOT00000007768 |
| Homologene ID | 4764 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1276535 |
|---|
| RGD ID | 620109 |
|---|
| MedScan ID | 8202 |
|---|