Protein Nfe2l2

URN	urn:agi-llid:4780
Total Entities	0
Connectivity	2988
Name	Nfe2l2
Description	nuclear factor, erythroid 2-like 2
Notes	This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GO Molecular Function	sequence-specific DNA binding transcription factor activity
	protein domain specific binding
	RNA polymerase II activating transcription factor binding
	DNA binding
	sequence-specific DNA binding

GO Biological Process	regulation of removal of superoxide radicals
	positive regulation of blood coagulation
	regulation of embryonic development
	negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress
	endoplasmic reticulum unfolded protein response
	negative regulation of cell death
	negative regulation of endothelial cell apoptotic process
	cellular response to hydrogen peroxide
	cellular response to oxidative stress
	cellular response to tumor necrosis factor
	positive regulation of transcription from RNA polymerase II promoter in response to stress
	cellular response to laminar fluid shear stress
	positive regulation of reactive oxygen species metabolic process
	positive regulation of transcription, DNA-templated
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-templated
	transcription, DNA-templated
	transcription from RNA polymerase II promoter
	protein ubiquitination
	proteasome-mediated ubiquitin-dependent protein catabolic process
	proteasomal ubiquitin-independent protein catabolic process

Pathway	Proteins Involved in Pathogenesis of Parkinson's Disease
	CFTR Up-regulates the Oxidative Stress in Airway Epithelium in Cystic Fibrosis
	Airway Epithelial Cell Dysfunction in Cystic Fibrosis (Overview)
	Proteins Involved in Pathogenesis of Amyotrophic Lateral Sclerosis
	Oxidative Stress in Amyotrophic Lateral Sclerosis
	nuclear factor, erythroid 2 like 2 signaling pathway

Group	NF-E2
	regulation of removal of superoxide radicals
	positive regulation of blood coagulation
	regulation of embryonic development
	negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress
	endoplasmic reticulum unfolded protein response
	negative regulation of cell death
	negative regulation of endothelial cell apoptotic process
	cellular response to hydrogen peroxide
	cellular response to oxidative stress
	cellular response to tumor necrosis factor
	positive regulation of transcription from RNA polymerase II promoter in response to stress
	cellular response to laminar fluid shear stress
	positive regulation of reactive oxygen species metabolic process
	positive regulation of transcription, DNA-templated
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-templated
	sequence-specific DNA binding transcription factor activity
	transcription, DNA-templated
	transcription from RNA polymerase II promoter
	protein ubiquitination
	proteasome-mediated ubiquitin-dependent protein catabolic process
	proteasomal ubiquitin-independent protein catabolic process
	protein domain specific binding
	RNA polymerase II activating transcription factor binding
	DNA binding
	sequence-specific DNA binding
	chromatin
	centrosome
	plasma membrane
	cytoplasm
	cytosol
	nucleus
	Secreted proteins

Alias	NRF2
	nuclear factor erythroid 2-related factor 2
	HEBP1
	NFE2-related factor 2
	NF-E2-related factor 2
	nuclear factor erythroid-derived 2-like 2
	nuclear factor (erythroid-derived 2)-like 2
	nuclear factor, erythroid derived 2, like 2
	AI194320
	RP23-374O4.2
	nuclear factor erythroid 2-like 2
	nuclear factor NRF2
	OTTHUMP00000164988
	OTTHUMP00000207980
	transcription factor NF E2 related factor 2
	transcription factor NRF2
	OTTHUMP00000205251
	transcription factor NF E2 related nuclear factor 2
	Nfe2l2
	OTTMUSP00000014243
	nuclear factor-erythroid 2-related factor 2
	LOC112634
	NF-E2 related factor II
	NFE2-related factor II
	NF-E2 related factor 2

Mouse chromosome position	2 44.75 cM

OMIM ID	600492

Rat chromosome position	3q23

Hugo ID	7782

Human chromosome position	2q31

PIR ID	I49261

Homologene ID	2412

MGI ID	108420

RGD ID	620360

MedScan ID	4780