Protein Keap1

URN	urn:agi-llid:9817
Total Entities	0
Connectivity	618
Name	Keap1
Description	kelch-like ECH-associated protein 1
Notes	This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

GO Cellular Component	nucleolus
	centrosome
	Cul3-RING ubiquitin ligase complex
	midbody
	cytoplasm
	endoplasmic reticulum
	nucleus
	cell-cell adherens junction
	focal adhesion

GO Biological Process	alkanesulfonate metabolic process
	malate metabolic process
	regulation of epidermal cell differentiation
	in utero embryonic development
	cytoplasmic sequestering of transcription factor
	response to metal ion
	cellular response to organic cyclic compound
	cellular response to interleukin-4
	response to thyroid hormone
	response to immobilization stress
	regulation of transcription, DNA-templated
	negative regulation of gene expression
	selenium compound metabolic process
	transcription, DNA-templated
	protein ubiquitination
	proteasomal ubiquitin-independent protein catabolic process
	flavonoid metabolic process
	protein oligomerization

Pathway	Adherens Junction Assembly (Nectin)
	CFTR Up-regulates the Oxidative Stress in Airway Epithelium in Cystic Fibrosis
	Proteins Involved in Pathogenesis of Amyotrophic Lateral Sclerosis
	Oxidative Stress in Amyotrophic Lateral Sclerosis
	nuclear factor, erythoid 2 like 2 signaling pathway

Group	alkanesulfonate metabolic process
	malate metabolic process
	regulation of epidermal cell differentiation
	in utero embryonic development
	cytoplasmic sequestering of transcription factor
	response to metal ion
	cellular response to organic cyclic compound
	cellular response to interleukin-4
	response to thyroid hormone
	response to immobilization stress
	regulation of transcription, DNA-templated
	negative regulation of gene expression
	selenium compound metabolic process
	transcription, DNA-templated
	protein ubiquitination
	proteasomal ubiquitin-independent protein catabolic process
	flavonoid metabolic process
	protein oligomerization
	nucleolus
	centrosome
	Cul3-RING ubiquitin ligase complex
	midbody
	cytoplasm
	endoplasmic reticulum
	nucleus
	cell-cell adherens junction
	focal adhesion

Cell Localization	Cytoplasm
	Nucleus

Alias	INrf2
	KLHL19
	kelch-like ECH-associated protein 1
	kelch-like protein 19
	cytosolic inhibitor of Nrf2
	kelch-like family member 19
	mKIAA0132
	ring canal protein
	NRF2 cytosolic inhibitor
	Kiaa0132
	MGC4407
	MGC9454
	ring canal ECH-associated 1
	ring canal ECH-associated I
	ring canal kelch-like protein
	MGC1114
	kelch like ECH associating protein 1
	MGC10630
	KEAP I
	MGC20887
	KEAP1
	Kelch-like ECH-associated protein I
	LOC112811

Mouse chromosome position	9

OMIM ID	606016

Rat chromosome position	8q13

Hugo ID	23177

Human chromosome position	19p13.2

Swiss-Prot ID	KEAP1_MOUSE
	KEAP1_HUMAN

Homologene ID	8184

MGI ID	1858732

RGD ID	621619

MedScan ID	9817