| URN | urn:agi-llid:2932 |
|---|---|
| Total Entities | 0 |
| Connectivity | 3992 |
| Name | Gsk3b |
| Description | glycogen synthase kinase 3 beta |
| Notes | mediates Par6-atypical protein kinase C (aPKC) complex regulation of cell polarity; may induce apoptosis [RGD] |
| GO Molecular Function | transferase activity |
|---|---|
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| tau-protein kinase activity | |
| protein serine-threonine kinase activity | |
| beta-catenin binding | |
| p53 binding | |
| integrin binding | |
| RNA polymerase II transcription factor binding | |
| NF-kappaB binding | |
| ionotropic glutamate receptor binding | |
| protein kinase binding | |
| protein kinase A catalytic subunit binding | |
| ubiquitin protein ligase binding | |
| tau protein binding | |
| nucleotide binding | |
| ATP binding |
| GO Cellular Component | membrane |
|---|---|
| membrane raft | |
| nucleolus | |
| centrosome | |
| ribonucleoprotein complex | |
| protein complex | |
| beta-catenin destruction complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| perinuclear region of cytoplasm | |
| nucleus | |
| growth cone | |
| dendritic spine | |
| dendritic shaft | |
| neuronal cell body | |
| membrane-bounded organelle |
| GO Biological Process | innate immune response |
|---|---|
| Fc-epsilon receptor signaling pathway | |
| cell proliferation | |
| negative regulation of glycogen biosynthetic process | |
| negative regulation of MAP kinase activity | |
| positive regulation of Rac GTPase activity | |
| glycogen metabolic process | |
| multicellular organismal development | |
| negative regulation of cardiac muscle hypertrophy | |
| nervous system development | |
| organ morphogenesis | |
| epithelial to mesenchymal transition | |
| hippocampus development | |
| superior temporal gyrus development | |
| negative regulation of type B pancreatic cell development | |
| negative regulation of dendrite morphogenesis | |
| axonogenesis | |
| axon guidance | |
| myoblast fusion | |
| cell differentiation | |
| fat cell differentiation | |
| positive regulation of stem cell differentiation | |
| myotube differentiation | |
| establishment or maintenance of cell polarity | |
| positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | |
| re-entry into mitotic cell cycle | |
| regulation of microtubule-based process | |
| negative regulation of signal transduction | |
| intracellular signal transduction | |
| phosphatidylinositol-mediated signaling | |
| extrinsic apoptotic signaling pathway in absence of ligand | |
| negative regulation of canonical Wnt signaling pathway | |
| Wnt signaling pathway | |
| canonical Wnt signaling pathway | |
| canonical Wnt signaling pathway involved in positive regulation of apoptotic process | |
| neurotrophin TRK receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| ER overload response | |
| regulation of neuronal synaptic plasticity | |
| positive regulation of cell-matrix adhesion | |
| cell migration | |
| establishment of cell polarity | |
| positive regulation of apoptotic process | |
| negative regulation of apoptotic process | |
| protein export from nucleus | |
| negative regulation of NFAT protein import into nucleus | |
| positive regulation of protein export from nucleus | |
| response to drug | |
| response to lithium ion | |
| cellular response to interleukin-3 | |
| cellular response to mechanical stimulus | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-threonine phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of protein catabolic process | |
| positive regulation of protein complex assembly | |
| negative regulation of protein complex assembly | |
| negative regulation of transcription, DNA-templated | |
| hypermethylation of CpG island | |
| regulation of gene expression by genetic imprinting | |
| negative regulation of glycogen (starch) synthase activity | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| phosphorylation | |
| carbohydrate metabolic process | |
| cytoskeleton organization | |
| circadian rhythm | |
| protein localization to microtubule | |
| negative regulation of protein binding | |
| positive regulation of protein binding |
| Pathway | Cell Cycle |
|---|---|
| Beta-Catenin to Androgen Receptor Signaling in Prostate Cancer | |
| Fatty Acid Synthase Signaling in Prostate Cancer | |
| Androgen Receptor to Akt Signaling in Prostate Cancer | |
| Prostate Cancer Overview | |
| Metastatic Colorectal Cancer Overview | |
| Myostatin-IGF1 Crosstalk in Skeletal Muscles | |
| IL6 in Insulin Resistance | |
| Duchenne Muscular Dystrophy Overview | |
| IGF1 in Muscle Hypertrophy | |
| RARA Signaling Pathway in Acute Myeloid Leukemia (M3) | |
| Acute Myeloid Leukemia Overview | |
| Alzheimer's Disease Overview | |
| Proteins Involved in Pathogenesis of Alzheimer's Disease | |
| Neurofibrillary Tangle Formation in Alzheimer's Disease | |
| WNT Inhibition by DKK1 in Osteoblast in Multiple Myeloma | |
| Proteins Involved in Pathogenesis of Chronic Myeloid Leukemia | |
| B-cell Acute Lymphoblastic Leukemia Overview | |
| T-cell Acute Lymphoblastic Leukemia Overview | |
| Proteins Involved in Pathogenesis of B-cell Chronic Lymphocytic Leukemia | |
| Proteins Involved in Pathogenesis of Parkinson's Disease | |
| Multiple Functions of Estrogen in Mitochondria in Alzheimer's Disease | |
| APP and Glutamate Signaling-Related Neuronal Dysfunction in Alzheimer's Disease | |
| Cowden Syndrome | |
| Mantle Cell Lymphoma Overview | |
| Deregulation of Cell Cycle and DNA Repair in Mantle Cell Lymphoma | |
| Canonical WNT Signaling in Mantle Cell Lymphoma | |
| Hedgehog Signaling in Mantle Cell Lymphoma | |
| Proteins Involved in Pathogenesis of Mantle Cell Lymphoma | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to IGF1R/Akt Signaling Pathway | |
| Breast Cancer Related to IGF1R/Akt Signaling Pathway | |
| Breast Cancer Related to WNT Signaling Pathway | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to WNT Signaling Pathway | |
| Breast Cancer Related to ERBB/VEGFR/Akt Signaling Pathway | |
| Breast Cancer Related to ESR1 Signaling Pathway | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to ESR1 Signaling Pathway | |
| ESR1/ERBB-positive Luminal Breast Cancer | |
| Basal Breast Cancer | |
| Proliferative Diabetic Retinopathy | |
| Insulin Influence on Glycogenesis | |
| Insulin Influence on Protein Synthesis | |
| Proteins Involved in Pathogenesis of Insulin Resistance | |
| Proteins Involved in Pathogenesis of Diabetes Mellitus Type 2 | |
| Effects of Hyperthyroidism on Bone Remodeling | |
| Clear Cell Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Clear Cell Ovarian Carcinoma | |
| Mucinous Ovarian Carcinoma | |
| High-grade Serous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Mucinous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of High-grade Serous Ovarian Carcinoma | |
| Endometrioid Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Endometrioid Ovarian Carcinoma | |
| Ovarian Cancer Overview | |
| Low-grade Serous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Low-grade Serous Ovarian Carcinoma | |
| Type I Endometrial Cancer (Endometrioid Endometrial Cancer) | |
| Type II Endometrial Cancer (Clear-cell Endometrial Cancer and Papillary Serous Endometrial Cancer) | |
| Endometrial Cancer Overview | |
| Deregulation of Cell Cycle in Melanoma | |
| MITF as a Regulator of Melanoma Cell Development | |
| WNT Signaling in Melanoma | |
| Melanoma Overview | |
| Proteins Involved in Pathogenesis of Prostate Cancer | |
| Cancer Overview | |
| Proteins Involved in Pathogenesis of Hypertrophic Cardiomyopathy | |
| Mechanisms of Cardiomyocyte Hypertrophy in Hypertrophic Cardiomyopathy | |
| Hypertrophic Cardiomyopathy Overview | |
| Endothelial Cell Dysfunction in Pulmonary Arterial Hypertension | |
| BMP2 Activates Canonical WNT Signaling in Pulmonary Artery Endothelial Cells | |
| BMP2 Activates WNT Signaling in Pulmonary Artery Smooth Muscle Cells | |
| Primary Glioblastoma | |
| Secondary Glioblastoma | |
| Proteins Involved in Pathogenesis of Glioblastoma | |
| Activation of Glioma Stem Cell Program | |
| Astrocytoma | |
| Medulloblastoma Overview | |
| Osteoarthritis Overview | |
| Steroid-Induced Cataract | |
| Sonic Hedgehog Signaling in Neuroblastoma | |
| Growth Factor Signaling in Neuroblastoma | |
| Proteins Involved in Pathogenesis of Neuroblastoma | |
| Neuroblastoma Overview | |
| Growth Factor Signaling in Pancreatic Cancer | |
| Pancreatic Ductal Carcinoma | |
| Proteins Involved in Pathogenesis of Pancreatic Cancer | |
| Proteins Involved in Pathogenesis of Polycystic Ovary Syndrome | |
| Block of Ovulation in Polycystic Ovary Syndrome | |
| Polycystic Ovary Syndrome Overview | |
| WNT/beta-Catenin Signaling in Hepatocellular Carcinoma | |
| Growth Factor Signaling in Hepatocellular Carcinoma | |
| Hepatocellular Carcinoma Overview | |
| Proteins Involved in Pathogenesis of Amyotrophic Lateral Sclerosis | |
| Cytokine-Dependent Synovial Fibroblast Activation in Rheumatoid Arthritis | |
| Induction of Apoptosis and Immediate Early Gene Activation in Hippocampal Neurons Following Seizures | |
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| Preconditioning Ischemia | |
| TNFRSF5/13B -> NFATC1 signaling | |
| FrizzledR -> CTNNB signaling | |
| VEGFR -> CTNNB signaling | |
| InsulinR -> CTNNB/FOXA/FOXO signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| GDNF -> HSF1 signaling | |
| NTRK -> FOXO/MYCN signaling | |
| MacrophageR -> CEBPB/NF-kB signaling | |
| FibronectinR -> CTNNB signaling | |
| ICAM2 -> CTNNB/FOXO/STAT3 signaling | |
| IL12R -> NF-kB/NFATC signaling | |
| IL15R -> NF-kB/NFATC signaling | |
| Dexamethasone-Induced Neurotoxicity | |
| Dexamethasone-Induced Diabetes | |
| Valdecoxib-Induced Ischemic Disease | |
| Canonical WNT Signaling Expression Targets | |
| WNT7A Expression Targets | |
| WNT1 Expression Targets | |
| WNT4 Expression Targets | |
| WNT3A Expression Targets | |
| WNT2 Expression Targets | |
| WNT7B Expression Targets | |
| NGF/FOXO/MYCN/ELK-SRF Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| TNFSF13B Expression Targets | |
| ICAM1 Expression Targets | |
| Fibrinogen Expression Targets | |
| Fibronectin Expression Targets | |
| IL12B Expression Targets | |
| IL15 Expression Targets | |
| VEGFA/CTNNB/CTNND Expression Targets | |
| VEGFC/CTNNB Expression Target | |
| GDNF/HSF1 Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| WNT5A Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| WNT9B Expression Targets | |
| WNT9A Expression Targets | |
| Wnt signaling, canonical pathway | |
| Wnt signaling, canonical pathway | |
| altered Wnt signaling, canonical pathway | |
| canonical Wnt signaling pathway | |
| integrin mediated signaling pathway | |
| altered canonical Wnt signaling pathway | |
| integrin mediated signaling pathway | |
| canonical Wnt signaling pathway | |
| altered canonical Wnt signaling pathway | |
| nuclear factor, erythoid 2 like 2 signaling pathway |
| Group | GSK3 |
|---|---|
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| cell proliferation | |
| negative regulation of glycogen biosynthetic process | |
| negative regulation of MAP kinase activity | |
| positive regulation of Rac GTPase activity | |
| glycogen metabolic process | |
| multicellular organismal development | |
| negative regulation of cardiac muscle hypertrophy | |
| nervous system development | |
| organ morphogenesis | |
| epithelial to mesenchymal transition | |
| hippocampus development | |
| superior temporal gyrus development | |
| negative regulation of type B pancreatic cell development | |
| negative regulation of dendrite morphogenesis | |
| axonogenesis | |
| axon guidance | |
| myoblast fusion | |
| cell differentiation | |
| fat cell differentiation | |
| positive regulation of stem cell differentiation | |
| myotube differentiation | |
| establishment or maintenance of cell polarity | |
| positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | |
| re-entry into mitotic cell cycle | |
| regulation of microtubule-based process | |
| negative regulation of signal transduction | |
| intracellular signal transduction | |
| phosphatidylinositol-mediated signaling | |
| extrinsic apoptotic signaling pathway in absence of ligand | |
| negative regulation of canonical Wnt signaling pathway | |
| Wnt signaling pathway | |
| canonical Wnt signaling pathway | |
| canonical Wnt signaling pathway involved in positive regulation of apoptotic process | |
| neurotrophin TRK receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| ER overload response | |
| regulation of neuronal synaptic plasticity | |
| positive regulation of cell-matrix adhesion | |
| cell migration | |
| establishment of cell polarity | |
| positive regulation of apoptotic process | |
| negative regulation of apoptotic process | |
| protein export from nucleus | |
| negative regulation of NFAT protein import into nucleus | |
| positive regulation of protein export from nucleus | |
| response to drug | |
| response to lithium ion | |
| cellular response to interleukin-3 | |
| cellular response to mechanical stimulus | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-threonine phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of protein catabolic process | |
| positive regulation of protein complex assembly | |
| negative regulation of protein complex assembly | |
| negative regulation of transcription, DNA-templated | |
| hypermethylation of CpG island | |
| regulation of gene expression by genetic imprinting | |
| negative regulation of glycogen (starch) synthase activity | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| tau-protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| phosphorylation | |
| carbohydrate metabolic process | |
| cytoskeleton organization | |
| circadian rhythm | |
| protein localization to microtubule | |
| negative regulation of protein binding | |
| positive regulation of protein binding | |
| beta-catenin binding | |
| p53 binding | |
| integrin binding | |
| RNA polymerase II transcription factor binding | |
| NF-kappaB binding | |
| ionotropic glutamate receptor binding | |
| protein kinase binding | |
| protein kinase A catalytic subunit binding | |
| ubiquitin protein ligase binding | |
| tau protein binding | |
| nucleotide binding | |
| ATP binding | |
| membrane | |
| membrane raft | |
| nucleolus | |
| centrosome | |
| ribonucleoprotein complex | |
| protein complex | |
| beta-catenin destruction complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| perinuclear region of cytoplasm | |
| nucleus | |
| growth cone | |
| dendritic spine | |
| dendritic shaft | |
| neuronal cell body | |
| membrane-bounded organelle | |
| Proteins Involved in Pathogenesis of Cowden Syndrome | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| LocusLink ID | 2932 |
|---|---|
| 56637 | |
| 84027 | |
| 56493 | |
| 78144 | |
| 98033 | |
| 66806 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Cell membrane | |
| Membrane |
| GO ID | 0005524 |
|---|---|
| 0051059 | |
| 0001085 | |
| 0008013 | |
| 0005178 | |
| 0035255 | |
| 0016301 | |
| 0002039 | |
| 0034236 | |
| 0019901 | |
| 0004674 | |
| 0048156 | |
| 0050321 | |
| 0031625 | |
| 0006983 | |
| 0038095 | |
| 0007411 | |
| 0060070 | |
| 0044337 | |
| 0016477 | |
| 0036016 | |
| 0007623 | |
| 0007173 | |
| 0001837 | |
| 0030010 | |
| 0097192 | |
| 0045444 | |
| 0008543 | |
| 0005977 | |
| 0021766 | |
| 0044027 | |
| 0045087 | |
| 0035556 | |
| 0007520 | |
| 0043407 | |
| 0051534 | |
| 0043066 | |
| 0090090 | |
| 0050774 | |
| 2000466 | |
| 0045719 | |
| 0032091 | |
| 0031333 | |
| 0045892 | |
| 2000077 | |
| 0048011 | |
| 0009887 | |
| 0018105 | |
| 0048015 | |
| 0032855 | |
| 0001954 | |
| 1901030 | |
| 0033138 | |
| 0010800 | |
| 0032092 | |
| 0045732 | |
| 0031334 | |
| 0046827 | |
| 2000738 | |
| 0045944 | |
| 0006611 | |
| 0035372 | |
| 0006468 | |
| 0000320 | |
| 0006349 | |
| 0032886 | |
| 0048168 | |
| 0042493 | |
| 0010226 | |
| 0071109 | |
| 0030877 | |
| 0005813 | |
| 0005737 | |
| 0005829 | |
| 0043198 | |
| 0043197 | |
| 0030426 | |
| 0045121 | |
| 0043025 | |
| 0005730 | |
| 0005634 | |
| 0048471 | |
| 0005886 | |
| 0030529 | |
| 0000166 | |
| 0004672 | |
| 0016740 | |
| 0016772 | |
| 0016055 | |
| 0007409 | |
| 0005975 | |
| 0030154 | |
| 0008283 | |
| 0071260 | |
| 0007010 | |
| 0007163 | |
| 0007275 | |
| 0014902 | |
| 0010614 | |
| 0009968 | |
| 0007399 | |
| 0016310 | |
| 0043065 | |
| 0032436 | |
| 0016020 | |
| 0043227 | |
| 0043234 | |
| 0006917 | |
| 0006950 | |
| 0034747 | |
| 0005654 | |
| 0006916 | |
| 0004696 | |
| 0023034 | |
| 0005625 | |
| 0007242 | |
| 0005515 | |
| 0004682 | |
| 0004691 |
| Alias | glycogen synthase kinase-3 beta |
|---|---|
| GSK-3 beta | |
| GSK3beta isoform | |
| serine/threonine-protein kinase GSK3B | |
| GSK3 | |
| GSK-3 | |
| C86142 | |
| GSK-3beta | |
| 7330414F15Rik | |
| 8430431H08Rik | |
| FA | |
| factor A | |
| KG3B_HUMAN | |
| KG3B | |
| RIKEN cDNA 8430431H08 gene | |
| RIKEN cDNA 7330414F15 gene | |
| OTTMUSP00000017446 | |
| OTTMUSP00000017445 | |
| 7330414F15 | |
| LOC56493 | |
| glycogen synthetase kinase 3 beta | |
| glycogen synthase kinase 3 beta | |
| 8430431H08 | |
| GSK3B | |
| GSK IIIs | |
| GSK III | |
| C86142s | |
| expressed sequence C86142 |
| Mouse chromosome position | 16 |
|---|---|
| 16 B4 |
| OMIM ID | 605004 |
|---|
| Rat chromosome position | 11q21 |
|---|
| Hugo ID | 4617 |
|---|
| Human chromosome position | 3q13.3 |
|---|
| Swiss-Prot Accession | P49841 |
|---|---|
| Q6FI27 | |
| Q5KU03 | |
| Q9WV60 | |
| P18266 | |
| D3DN89 | |
| Q9BWH3 | |
| Q9UL47 | |
| Q3TB31 |
| PIR ID | S14708 |
|---|---|
| S53324 |
| Unigene ID | Hs.445733 |
|---|---|
| Mm.394930 | |
| Rn.10426 | |
| Hs.593022 | |
| Mm.200770 |
| KEGG ID | hsa:2932 |
|---|---|
| mmu:56637 | |
| rno:84027 |
| Swiss-Prot ID | GSK3B_MOUSE |
|---|---|
| GSK3B_RAT | |
| GSK3B_HUMAN | |
| D3DN89_HUMAN | |
| Q6FI27_HUMAN | |
| Q5KU03_MOUSE |
| EC Number | 2.7.11.26 |
|---|---|
| 2.7.11.1 |
| Ensembl ID | ENSG00000082701 |
|---|---|
| ENSP00000264235 | |
| ENST00000264235 | |
| ENSMUSG00000022812 | |
| ENSMUSP00000023507 | |
| ENSMUST00000023507 | |
| ENSRNOG00000002833 | |
| ENSRNOP00000003867 | |
| ENSRNOT00000003867 |
| Homologene ID | 55629 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1861437 |
|---|---|
| 1914056 | |
| 1925394 | |
| 2146721 |
| RGD ID | 70982 |
|---|
| MedScan ID | 2932 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00125319 |
|---|---|
| IPI00324168 | |
| IPI00028570 | |
| IPI00216190 | |
| IPI00750061 |