| URN | urn:agi-llid:2931 |
|---|---|
| Total Entities | 0 |
| Connectivity | 529 |
| Name | Gsk3a |
| Description | glycogen synthase kinase 3 alpha |
| Notes | This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011] |
| GO Molecular Function | transferase activity |
|---|---|
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| tau-protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein kinase A catalytic subunit binding | |
| nucleotide binding | |
| ATP binding |
| GO Cellular Component | beta-catenin destruction complex |
|---|---|
| cytosol |
| GO Biological Process | innate immune response |
|---|---|
| Fc-epsilon receptor signaling pathway | |
| negative regulation of glycogen biosynthetic process | |
| positive regulation of cAMP biosynthetic process | |
| negative regulation of UDP-glucose catabolic process | |
| glycogen metabolic process | |
| positive regulation of heart contraction | |
| negative regulation of cell growth involved in cardiac muscle cell development | |
| regulation of systemic arterial blood pressure | |
| nervous system development | |
| cardiac left ventricle morphogenesis | |
| negative regulation of type B pancreatic cell development | |
| positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | |
| signal transduction | |
| negative regulation of signal transduction | |
| negative regulation of TOR signaling | |
| phosphatidylinositol-mediated signaling | |
| extrinsic apoptotic signaling pathway in absence of ligand | |
| positive regulation of adrenergic receptor signaling pathway | |
| negative regulation of insulin receptor signaling pathway | |
| negative regulation of canonical Wnt signaling pathway | |
| Wnt signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| insulin receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| endoplasmic reticulum unfolded protein response | |
| activation of signaling protein activity involved in unfolded protein response | |
| cell migration | |
| negative regulation of glucose import | |
| cellular response to insulin stimulus | |
| cellular response to lithium ion | |
| cellular response to organic cyclic compound | |
| cellular response to interleukin-3 | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-threonine phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of protein catabolic process | |
| hypermethylation of CpG island | |
| regulation of gene expression by genetic imprinting | |
| negative regulation of transferase activity | |
| negative regulation of glycogen (starch) synthase activity | |
| positive regulation of glycogen (starch) synthase activity | |
| cellular protein metabolic process | |
| protein phosphorylation | |
| proteasome-mediated ubiquitin-dependent protein catabolic process | |
| phosphorylation | |
| carbohydrate metabolic process |
| Pathway | Proteins Involved in Pathogenesis of Alzheimer's Disease |
|---|---|
| nuclear factor, erythoid 2 like 2 signaling pathway |
| Group | GSK3 |
|---|---|
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| negative regulation of glycogen biosynthetic process | |
| positive regulation of cAMP biosynthetic process | |
| negative regulation of UDP-glucose catabolic process | |
| glycogen metabolic process | |
| positive regulation of heart contraction | |
| negative regulation of cell growth involved in cardiac muscle cell development | |
| regulation of systemic arterial blood pressure | |
| nervous system development | |
| cardiac left ventricle morphogenesis | |
| negative regulation of type B pancreatic cell development | |
| positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | |
| signal transduction | |
| negative regulation of signal transduction | |
| negative regulation of TOR signaling | |
| phosphatidylinositol-mediated signaling | |
| extrinsic apoptotic signaling pathway in absence of ligand | |
| positive regulation of adrenergic receptor signaling pathway | |
| negative regulation of insulin receptor signaling pathway | |
| negative regulation of canonical Wnt signaling pathway | |
| Wnt signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| insulin receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| endoplasmic reticulum unfolded protein response | |
| activation of signaling protein activity involved in unfolded protein response | |
| cell migration | |
| negative regulation of glucose import | |
| cellular response to insulin stimulus | |
| cellular response to lithium ion | |
| cellular response to organic cyclic compound | |
| cellular response to interleukin-3 | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-threonine phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of protein catabolic process | |
| hypermethylation of CpG island | |
| regulation of gene expression by genetic imprinting | |
| negative regulation of transferase activity | |
| negative regulation of glycogen (starch) synthase activity | |
| positive regulation of glycogen (starch) synthase activity | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| tau-protein kinase activity | |
| protein serine-threonine kinase activity | |
| cellular protein metabolic process | |
| protein phosphorylation | |
| proteasome-mediated ubiquitin-dependent protein catabolic process | |
| phosphorylation | |
| carbohydrate metabolic process | |
| protein kinase A catalytic subunit binding | |
| nucleotide binding | |
| ATP binding | |
| beta-catenin destruction complex | |
| cytosol |
| LocusLink ID | 2931 |
|---|---|
| 606496 | |
| 50686 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0005524 |
|---|---|
| 0034236 | |
| 0004674 | |
| 0050321 | |
| 0038095 | |
| 0016055 | |
| 0006987 | |
| 0003214 | |
| 0044267 | |
| 0032869 | |
| 0036016 | |
| 0030968 | |
| 0007173 | |
| 0097192 | |
| 0008543 | |
| 0005977 | |
| 0045087 | |
| 0008286 | |
| 0032007 | |
| 0010905 | |
| 0090090 | |
| 0061052 | |
| 0046325 | |
| 2000466 | |
| 0045719 | |
| 0046627 | |
| 0051348 | |
| 2000077 | |
| 0007399 | |
| 0048011 | |
| 0048015 | |
| 0071879 | |
| 0030819 | |
| 2000467 | |
| 0045823 | |
| 1901030 | |
| 0045732 | |
| 0043161 | |
| 0006468 | |
| 0003073 | |
| 0030877 | |
| 0005829 | |
| 0016301 | |
| 0000166 | |
| 0004672 | |
| 0016740 | |
| 0016772 | |
| 0005975 | |
| 0016477 | |
| 0071285 | |
| 0071407 | |
| 0044027 | |
| 0009968 | |
| 0016310 | |
| 0033138 | |
| 0010800 | |
| 0045944 | |
| 0006349 | |
| 0007165 |
| Alias | glycogen synthase kinase-3 alpha |
|---|---|
| GSK-3 alpha | |
| serine/threonine-protein kinase GSK3A | |
| 2700086H06Rik | |
| FA | |
| factor A | |
| GSK3A | |
| RIKEN cDNA 2700086H06 gene | |
| OTTMUSP00000023272 | |
| OTTHUMP00000198368 | |
| glycogen synthetase kinase 3 alpha | |
| glycogen synthase kinase 3 alpha | |
| DKFZp686d0638 | |
| 2700086H06 |
| Mouse chromosome position | 7 |
|---|
| OMIM ID | 606784 |
|---|
| Rat chromosome position | 1q21 |
|---|
| Hugo ID | 4616 |
|---|
| Human chromosome position | 19q13.2 |
|---|
| Swiss-Prot Accession | P49840 |
|---|---|
| Q2NL51 | |
| P18265 | |
| O14959 |
| PIR ID | S14707 |
|---|
| Unigene ID | Hs.466828 |
|---|---|
| Mm.491101 | |
| Rn.36807 |
| KEGG ID | hsa:2931 |
|---|---|
| mmu:606496 | |
| rno:50686 |
| Swiss-Prot ID | GSK3A_HUMAN |
|---|---|
| GSK3A_RAT | |
| GSK3A_MOUSE |
| EC Number | 2.7.11.26 |
|---|---|
| 2.7.11.1 |
| Ensembl ID | ENSG00000105723 |
|---|---|
| ENSP00000222330 | |
| ENST00000222330 | |
| ENSMUSG00000057177 | |
| ENSMUSP00000071654 | |
| ENSMUST00000071739 | |
| ENSRNOG00000020417 | |
| ENSRNOP00000027677 | |
| ENSRNOT00000027677 |
| Homologene ID | 88581 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2152453 |
|---|
| RGD ID | 620351 |
|---|
| MedScan ID | 2931 |
|---|