| URN | urn:agi-llid:5443 |
|---|---|
| Connectivity | 1735 |
| Name | Pomc |
| Description | proopiomelanocortin |
| Notes | This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq] |
| Pathway | OpioidR -> CREB/ELK-SRF/STAT3 signaling |
|---|---|
| melanocortin system pathway |
| GO Molecular Function | receptor binding |
|---|---|
| hormone activity | |
| G-protein-coupled receptor binding | |
| type 4 melanocortin receptor binding | |
| type 1 melanocortin receptor binding | |
| type 3 melanocortin receptor binding |
| GO Cellular Component | extracellular region |
|---|---|
| soluble fraction | |
| cytoplasm | |
| stored secretory granule |
| GO Biological Process | cell-cell signaling |
|---|---|
| negative regulation of tumor necrosis factor production | |
| signal transduction | |
| generation of precursor metabolites and energy | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| feeding behavior | |
| neuropeptide signaling pathway | |
| regulation of blood pressure |
| Ariadne Ontology | Neuromodulator |
|---|
| Group | Neuromodulator |
|---|---|
| extracellular region | |
| cell-cell signaling | |
| negative regulation of tumor necrosis factor production | |
| signal transduction | |
| generation of precursor metabolites and energy | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| feeding behavior | |
| neuropeptide signaling pathway | |
| regulation of blood pressure | |
| receptor binding | |
| hormone activity | |
| G-protein-coupled receptor binding | |
| type 4 melanocortin receptor binding | |
| type 1 melanocortin receptor binding | |
| type 3 melanocortin receptor binding | |
| soluble fraction | |
| cytoplasm | |
| stored secretory granule |
| MedScan ID | 5443 |
|---|
| Hugo ID | 9201 |
|---|
| Human chromosome position | 2p23.3 |
|---|
| LocusLink ID | 5443 |
|---|---|
| 18976 | |
| 24664 |
| Alias | LPH |
|---|---|
| MSH | |
| NPP | |
| POC | |
| ACTH | |
| CLIP | |
| pro-opiomelanocortin | |
| beta-LPH | |
| beta-MSH | |
| alpha-MSH | |
| gamma-LPH | |
| gamma-MSH | |
| beta-endorphin | |
| met-enkephalin | |
| lipotropin beta | |
| lipotropin gamma | |
| melanotropin beta | |
| OTTHUMP00000200964 | |
| OTTHUMP00000200965 | |
| melanotropin alpha | |
| melanotropin gamma | |
| pro-ACTH-endorphin | |
| adrenocorticotropin | |
| corticotropin-lipotropin | |
| adrenocorticotropic hormone | |
| proopiomelanocortin preproprotein | |
| beta-melanocyte-stimulating hormone | |
| alpha-melanocyte-stimulating hormone | |
| corticotropin-like intermediary peptide | |
| BE | |
| Pomc1 | |
| Pomc-1 | |
| alphaMSH | |
| adrenal corticotropic hormone | |
| beta-melanocyte stimulating hormone | |
| alpha-melanocyte stimulating hormone | |
| gamma-melanocyte stimulating hormone | |
| Pomc2 | |
| pro-opiomelanocortin-alpha | |
| proopiomelanocortin, beta (endorphin, beta) | |
| proopoimelanocortin, beta (endorphin, beta) | |
| proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) | |
| adrenocorticotrophic hormone | |
| adrenocorticotrophin | |
| alpha-melanocyte stimulation hormone | |
| alpha-melanotrophin | |
| alpha-melanotropin | |
| beta proopiomelanocortin | |
| beta-lipotropin | |
| beta-melanocyte stimulation hormone | |
| beta-melanotrophin | |
| beta-melanotropin | |
| corticotrophin | |
| corticotrophin-like intermediary peptide | |
| corticotrophin-lipotrophin | |
| corticotrophin-lipotropin | |
| corticotropin | |
| corticotropin-lipotrophin | |
| endorphin, beta | |
| gamma-melanotrophin | |
| gamma-melanotropin | |
| melanotrophin | |
| melanotrophin alpha | |
| melanotrophin beta | |
| melanotrophin gamma | |
| melanotropin | |
| N-Acetyl-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 | |
| OTTHUMP00000119991 | |
| POMC | |
| Pomc I | |
| proopiomelanocortin | |
| Proopiomelanocortin (adrenocorticotrophin/beta-lipotropin) | |
| Proopiomelanocortin (adrenocorticotropin/beta-lipotropin) | |
| proopiomelanocortin, beta | |
| proopoimelanocortin, beta |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 176830 |
|---|---|
| 609734 | |
| 601665 |
| Mouse chromosome position | 12 4.0 cM |
|---|
| GO ID | 0001664 |
|---|---|
| 0005179 | |
| 0005102 | |
| 0070996 | |
| 0031781 | |
| 0031782 | |
| 0007267 | |
| 0006091 | |
| 0032720 | |
| 0007218 | |
| 0010552 | |
| 0008217 | |
| 0007165 | |
| 0005737 | |
| 0005576 | |
| 0005625 | |
| 0030141 | |
| 0007631 |
| Rat chromosome position | 6q14 |
|---|
| Swiss-Prot Accession | P01189 |
|---|---|
| Q53T23 | |
| Q6FHC8 | |
| Q53WY7 | |
| Q5TZZ7 | |
| Q6LDP0 | |
| P01193 | |
| Q8K422 | |
| P01194 | |
| P01200 | |
| Q544U4 | |
| P78442 | |
| Q9UD39 | |
| Q9UD40 |
| PIR ID | A91312 |
|---|---|
| A17229 |
| Unigene ID | Hs.1897 |
|---|---|
| Mm.277996 | |
| Rn.108195 |
| KEGG ID | hsa:5443 |
|---|---|
| mmu:18976 | |
| rno:24664 |
| Swiss-Prot ID | COLI_MOUSE |
|---|---|
| COLI_HUMAN | |
| Q53T23_HUMAN | |
| Q6FHC8_HUMAN | |
| Q8K422_RAT |
| Cell Localization | Extracellular |
|---|
| IPI ID | IPI00132282 |
|---|---|
| IPI00000160 | |
| IPI00215322 | |
| IPI00816161 | |
| IPI00892848 | |
| IPI00211001 |
| Homologene ID | 723 |
|---|
| RGD ID | 3366 |
|---|
| MGI ID | 97742 |
|---|