| URN | urn:agi-llid:56246 |
|---|---|
| Connectivity | 7 |
| Name | Mrap |
| Description | melanocortin 2 receptor accessory protein |
| Notes | This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq] |
| Pathway | melanocortin system pathway |
|---|
| GO Molecular Function | type 4 melanocortin receptor binding |
|---|---|
| type 5 melanocortin receptor binding | |
| type 1 melanocortin receptor binding | |
| adrenocorticotropin hormone receptor binding | |
| type 3 melanocortin receptor binding |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| endoplasmic reticulum | |
| integral to membrane |
| GO Biological Process | brown fat cell differentiation |
|---|---|
| positive regulation of cAMP biosynthetic process | |
| protein localization at cell surface |
| Group | brown fat cell differentiation |
|---|---|
| positive regulation of cAMP biosynthetic process | |
| protein localization at cell surface | |
| type 4 melanocortin receptor binding | |
| type 5 melanocortin receptor binding | |
| type 1 melanocortin receptor binding | |
| adrenocorticotropin hormone receptor binding | |
| type 3 melanocortin receptor binding | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| endoplasmic reticulum | |
| integral to membrane |
| MedScan ID | 56246 |
|---|
| Hugo ID | 1304 |
|---|
| Human chromosome position | 21q22.1 |
|---|
| LocusLink ID | 56246 |
|---|---|
| 77037 | |
| 288271 |
| Alias | B27 |
|---|---|
| FALP | |
| FGD2 | |
| GCCD2 | |
| C21orf61 | |
| melanocortin-2 receptor accessory protein | |
| fat tissue-specific low MW protein | |
| fat cell-specific low molecular weight protein | |
| ORF61 | |
| 1110025G12Rik | |
| OTTMUSP00000021491 | |
| RGD1310648 | |
| chromosome 21 open reading frame 61 | |
| melanocortin 2 receptor accessory protein | |
| MRAP | |
| MRAPalpha | |
| MRAPbeta | |
| MRAPeta | |
| OTTHUMP00000107701 | |
| OTTHUMP00000107702 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 609196 |
|---|---|
| 607398 |
| Mouse chromosome position | 16 |
|---|
| GO ID | 0031780 |
|---|---|
| 0070996 | |
| 0031781 | |
| 0031782 | |
| 0031783 | |
| 0030819 | |
| 0034394 | |
| 0005737 | |
| 0005783 | |
| 0016021 | |
| 0048471 | |
| 0005886 | |
| 0050873 | |
| 0016020 |
| Rat chromosome position | 11q11 |
|---|
| Swiss-Prot Accession | Q8TCY5 |
|---|---|
| Q9D159 | |
| Q5EBR3 | |
| Q8TDB7 | |
| Q8WXC1 | |
| Q8WXC2 | |
| Q3TZ49 | |
| Q8R439 |
| PIR ID | JC7859 |
|---|
| Unigene ID | Hs.584940 |
|---|---|
| Mm.22455 | |
| Rn.45756 |
| KEGG ID | hsa:56246 |
|---|---|
| mmu:77037 | |
| rno:288271 |
| Swiss-Prot ID | MRAP_HUMAN |
|---|---|
| MRAP_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| perinuclear region | |
| Cell membrane | |
| Endoplasmic reticulum |
| IPI ID | IPI00154756 |
|---|---|
| IPI00219581 | |
| IPI00219582 | |
| IPI00556555 | |
| IPI00133194 | |
| IPI00227824 | |
| IPI00370792 |
| Homologene ID | 12669 |
|---|
| RGD ID | 1310648 |
|---|
| MGI ID | 1924287 |
|---|