| URN | urn:agi-llid:4159 |
|---|---|
| Connectivity | 66 |
| Name | Mc3r |
| Description | melanocortin 3 receptor |
| Notes | This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq] |
| Pathway | melanocortin system pathway |
|---|
| GO Molecular Function | signal transducer activity |
|---|---|
| peptide hormone binding | |
| melanocyte stimulating hormone receptor activity | |
| melanocortin receptor activity | |
| receptor activity | |
| G-protein coupled receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | signal transduction |
|---|---|
| activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger | |
| G-protein signaling, coupled to cyclic nucleotide second messenger | |
| G-protein signaling, coupled to cAMP nucleotide second messenger | |
| positive regulation of cAMP biosynthetic process | |
| G-protein coupled receptor protein signaling pathway |
| Ariadne Ontology | GPCR-Gq-sCR |
|---|
| Group | GPCR-Gq-sCR |
|---|---|
| signal transduction | |
| activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger | |
| G-protein signaling, coupled to cyclic nucleotide second messenger | |
| G-protein signaling, coupled to cAMP nucleotide second messenger | |
| positive regulation of cAMP biosynthetic process | |
| G-protein coupled receptor protein signaling pathway | |
| signal transducer activity | |
| peptide hormone binding | |
| melanocyte stimulating hormone receptor activity | |
| melanocortin receptor activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 4159 |
|---|
| Hugo ID | 6931 |
|---|
| Human chromosome position | 20q13.2-q13.3 |
|---|
| LocusLink ID | 4159 |
|---|---|
| 17201 | |
| 29310 |
| Alias | MC3 |
|---|---|
| OB20 | |
| OQTL | |
| BMIQ9 | |
| MC3-R | |
| melanocortin receptor 3 | |
| Obesity quantitative trait locus | |
| MGC124211 | |
| MGC124212 | |
| RP23-358I19.2 | |
| OTTMUSP00000017290 | |
| MC3 receptor | |
| MC3R | |
| melanocortin 3 receptor | |
| melanocortin 3 receptors | |
| OB 20 | |
| OB(20) | |
| OB-20 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 155540 |
|---|---|
| 607948 | |
| 601665 | |
| 602025 |
| Mouse chromosome position | 2 100.0 cM |
|---|
| GO ID | 0004930 |
|---|---|
| 0004977 | |
| 0004980 | |
| 0017046 | |
| 0004872 | |
| 0007188 | |
| 0007187 | |
| 0007200 | |
| 0030819 | |
| 0005887 | |
| 0005886 | |
| 0004871 | |
| 0007186 | |
| 0007165 | |
| 0016021 | |
| 0016020 |
| Rat chromosome position | 3q42 |
|---|
| Swiss-Prot Accession | P41968 |
|---|---|
| P33033 | |
| Q544G7 | |
| Q3ZAT4 | |
| Q4KXA4 | |
| P32244 | |
| Q4KN27 | |
| Q9H517 |
| PIR ID | B46647 |
|---|---|
| S43850 |
| Unigene ID | Hs.248018 |
|---|---|
| Mm.57183 | |
| Rn.215838 |
| KEGG ID | hsa:4159 |
|---|---|
| mmu:17201 | |
| rno:29310 |
| Swiss-Prot ID | MC3R_HUMAN |
|---|---|
| MC3R_MOUSE | |
| Q4KXA4_RAT | |
| Q544G7_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00018253 |
|---|---|
| IPI00108155 | |
| IPI00851120 | |
| IPI00214326 |
| Homologene ID | 7412 |
|---|
| RGD ID | 3056 |
|---|
| MGI ID | 96929 |
|---|