| URN | urn:agi-llid:4158 |
|---|---|
| Connectivity | 91 |
| Name | Mc2r |
| Description | melanocortin 2 receptor (adrenocorticotropic hormone) |
| Notes | MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. [provided by RefSeq] |
| Pathway | melanocortin system pathway |
|---|
| GO Molecular Function | signal transducer activity |
|---|---|
| adrenocorticotropin receptor activity | |
| melanocortin receptor activity | |
| receptor activity | |
| G-protein coupled receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | signal transduction |
|---|---|
| G-protein signaling, coupled to cyclic nucleotide second messenger | |
| positive regulation of cAMP biosynthetic process | |
| G-protein coupled receptor protein signaling pathway |
| Ariadne Ontology | GPCR-GsCR |
|---|
| Group | GPCR-GsCR |
|---|---|
| signal transduction | |
| G-protein signaling, coupled to cyclic nucleotide second messenger | |
| positive regulation of cAMP biosynthetic process | |
| G-protein coupled receptor protein signaling pathway | |
| signal transducer activity | |
| adrenocorticotropin receptor activity | |
| melanocortin receptor activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 4158 |
|---|
| Hugo ID | 6930 |
|---|
| Human chromosome position | 18p11.2 |
|---|
| LocusLink ID | 4158 |
|---|---|
| 17200 | |
| 282839 |
| Alias | ACTHR |
|---|---|
| MGC125798 | |
| adrenocorticotropic hormone receptor | |
| MC2 receptor | |
| ACTH receptor | |
| OTTHUMP00000162512 | |
| corticotropin receptor | |
| adrenocorticotropin receptor | |
| MC2-R | |
| ACTH-R | |
| melanocortin receptor 2 | |
| melanocortin 2 receptor | |
| ACTH receptors | |
| Adrenocorticotrophic hormone receptor | |
| Adrenocorticotrophic hormone receptors | |
| Adrenocorticotrophin receptor | |
| adrenocorticotrophin receptors | |
| Adrenocorticotropic hormone receptors | |
| adrenocorticotropin receptors | |
| corticotrophin receptor | |
| Mc2r | |
| melanocortin 2 receptor (adrenocorticotropic hormone) | |
| Melanocortin-2 receptor (ACTH receptor) | |
| Melanocortin-2 receptors |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607397 |
|---|---|
| 202200 |
| Mouse chromosome position | 18 37.0 cM |
|---|
| GO ID | 0004930 |
|---|---|
| 0004978 | |
| 0004977 | |
| 0004872 | |
| 0007186 | |
| 0007187 | |
| 0030819 | |
| 0005887 | |
| 0005886 | |
| 0004871 | |
| 0007165 | |
| 0016021 | |
| 0016020 |
| Rat chromosome position | 18q12.1 |
|---|
| Swiss-Prot Accession | A8K016 |
|---|---|
| Q01718 | |
| Q544P9 | |
| Q64326 | |
| Q8CIX6 | |
| Q3MI45 | |
| Q504X6 |
| PIR ID | C43265 |
|---|---|
| JC4046 |
| Unigene ID | Hs.248144 |
|---|---|
| Mm.426053 | |
| Rn.92460 |
| KEGG ID | hsa:4158 |
|---|---|
| mmu:17200 | |
| rno:282839 |
| Swiss-Prot ID | ACTHR_HUMAN |
|---|---|
| ACTHR_MOUSE | |
| A8K016_HUMAN | |
| Q544P9_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00009312 |
|---|---|
| IPI00133318 | |
| IPI00211221 |
| Homologene ID | 444 |
|---|
| RGD ID | 628649 |
|---|
| MGI ID | 96928 |
|---|