| URN | urn:agi-llid:434 |
|---|---|
| Connectivity | 59 |
| Name | Asip |
| Description | agouti signaling protein |
| Notes | In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq] |
| Pathway | melanocortin system pathway |
|---|
| GO Molecular Function | receptor binding |
|---|---|
| melanocortin receptor binding | |
| type 4 melanocortin receptor binding | |
| type 3 melanocortin receptor binding |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space |
| GO Biological Process | pigmentation |
|---|---|
| cell-cell signaling | |
| adult feeding behavior | |
| signal transduction | |
| generation of precursor metabolites and energy | |
| melanin biosynthetic process | |
| melanosome organization | |
| hormone-mediated signaling pathway | |
| melanosome transport |
| Ariadne Ontology | agouti |
|---|
| Group | agouti |
|---|---|
| extracellular region | |
| pigmentation | |
| cell-cell signaling | |
| adult feeding behavior | |
| signal transduction | |
| generation of precursor metabolites and energy | |
| melanin biosynthetic process | |
| melanosome organization | |
| hormone-mediated signaling pathway | |
| melanosome transport | |
| receptor binding | |
| melanocortin receptor binding | |
| type 4 melanocortin receptor binding | |
| type 3 melanocortin receptor binding | |
| extracellular space |
| MedScan ID | 434 |
|---|
| Hugo ID | 745 |
|---|
| Human chromosome position | 20q11.2-q12 |
|---|
| LocusLink ID | 434 |
|---|---|
| 50518 | |
| 24152 |
| Alias | ASP |
|---|---|
| AGSW | |
| AGTI | |
| AGTIL | |
| SHEP9 | |
| MGC126092 | |
| MGC126093 | |
| agouti-signaling protein | |
| nonagouti homolog | |
| agouti switch protein | |
| agouti signaling protein, nonagouti homolog | |
| As | |
| A<y> | |
| ASIP | |
| RP23-192A6.1 | |
| non-agouti | |
| OTTMUSP00000017061 | |
| OTTMUSP00000017084 | |
| OTTMUSP00000017085 | |
| agouti signal protein | |
| agouti coat color protein | |
| A | |
| Agouti (coat color) | |
| agouti (mouse)-signaling protein | |
| agouti gene | |
| agouti protein | |
| Agouti signaling protein | |
| agouti signaling protein, nonagouti homolog (mouse) | |
| nonagouti | |
| non-agouti homolog | |
| OTTHUMP00000030681 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600201 |
|---|---|
| 611742 |
| Mouse chromosome position | 2 89.0 cM |
|---|
| GO ID | 0005102 |
|---|---|
| 0031781 | |
| 0031782 | |
| 0008343 | |
| 0007267 | |
| 0006091 | |
| 0009755 | |
| 0042438 | |
| 0032438 | |
| 0032402 | |
| 0043473 | |
| 0007165 | |
| 0005576 | |
| 0005615 | |
| 0031779 |
| Rat chromosome position | 3q42 |
|---|
| Swiss-Prot Accession | P42127 |
|---|---|
| A2ALT3 | |
| Q03288 | |
| Q99JA2 | |
| Q3SXL2 |
| PIR ID | I37143 |
|---|
| Unigene ID | Hs.659995 |
|---|---|
| Mm.218753 | |
| Mm.221440 | |
| Mm.315593 | |
| Rn.205372 |
| KEGG ID | hsa:434 |
|---|---|
| mmu:50518 | |
| rno:24152 |
| Swiss-Prot ID | ASIP_HUMAN |
|---|---|
| ASIP_RAT | |
| A2ALT3_MOUSE |
| Cell Localization | Secreted |
|---|---|
| Extracellular |
| IPI ID | IPI00030037 |
|---|---|
| IPI00194973 | |
| IPI00844761 | |
| IPI00130315 | |
| IPI00753461 | |
| IPI00756983 |
| Homologene ID | 1264 |
|---|
| RGD ID | 2003 |
|---|
| MGI ID | 87853 |
|---|