| URN | urn:agi-llid:4160 |
|---|---|
| Connectivity | 144 |
| Name | Mc4r |
| Description | melanocortin 4 receptor |
| Notes | The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq] |
| Pathway | melanocortin system pathway |
|---|
| GO Molecular Function | signal transducer activity |
|---|---|
| peptide hormone binding | |
| melanocyte stimulating hormone receptor activity | |
| melanocortin receptor activity | |
| receptor activity | |
| G-protein coupled receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| cytoplasm | |
| integral to membrane |
| GO Biological Process | regulation of metabolic process |
|---|---|
| diet induced thermogenesis | |
| positive regulation of bone resorption | |
| signal transduction | |
| G-protein signaling, coupled to cAMP nucleotide second messenger | |
| positive regulation of cAMP biosynthetic process | |
| insulin secretion | |
| energy reserve metabolic process | |
| feeding behavior | |
| response to insulin stimulus | |
| G-protein coupled receptor protein signaling pathway |
| Ariadne Ontology | GPCR-GsCR |
|---|
| Group | GPCR-GsCR |
|---|---|
| regulation of metabolic process | |
| diet induced thermogenesis | |
| positive regulation of bone resorption | |
| signal transduction | |
| G-protein signaling, coupled to cAMP nucleotide second messenger | |
| positive regulation of cAMP biosynthetic process | |
| insulin secretion | |
| energy reserve metabolic process | |
| feeding behavior | |
| response to insulin stimulus | |
| G-protein coupled receptor protein signaling pathway | |
| signal transducer activity | |
| peptide hormone binding | |
| melanocyte stimulating hormone receptor activity | |
| melanocortin receptor activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| integral to membrane |
| MedScan ID | 4160 |
|---|
| Hugo ID | 6932 |
|---|
| Human chromosome position | 18q22 |
|---|
| LocusLink ID | 4160 |
|---|---|
| 17202 | |
| 25635 |
| Alias | MGC126851 |
|---|---|
| MGC138197 | |
| melanocortin receptor 4 | |
| MC4-R | |
| Glu3 | |
| Fatboy | |
| MC4R | |
| melanocortin 4 receptor | |
| melanocortin 4 receptors | |
| OTTHUMP00000163654 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 155541 |
|---|---|
| 601665 |
| Mouse chromosome position | 18 |
|---|
| GO ID | 0004930 |
|---|---|
| 0004977 | |
| 0004980 | |
| 0017046 | |
| 0004872 | |
| 0007188 | |
| 0002024 | |
| 0006112 | |
| 0007631 | |
| 0030073 | |
| 0045780 | |
| 0030819 | |
| 0019222 | |
| 0032868 | |
| 0016021 | |
| 0005886 | |
| 0004871 | |
| 0007186 | |
| 0007165 | |
| 0016020 | |
| 0005737 |
| Rat chromosome position | 18q12.1 |
|---|
| Swiss-Prot Accession | P32245 |
|---|---|
| Q49NR4 | |
| P56450 | |
| Q49NR1 | |
| P70596 | |
| B2RAC3 | |
| Q16317 | |
| Q3MIJ6 |
| PIR ID | A57055 |
|---|---|
| B57055 |
| Unigene ID | Hs.532833 |
|---|---|
| Mm.229447 | |
| Rn.10620 |
| KEGG ID | hsa:4160 |
|---|---|
| mmu:17202 | |
| rno:25635 |
| Swiss-Prot ID | MC4R_HUMAN |
|---|---|
| MC4R_RAT | |
| Q49NR4_MOUSE | |
| B2RAC3_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00027684 |
|---|---|
| IPI00189790 | |
| IPI00719990 | |
| IPI00111301 |
| Homologene ID | 4320 |
|---|
| RGD ID | 3057 |
|---|
| MGI ID | 99457 |
|---|