| URN | urn:agi-llid:181 |
|---|---|
| Connectivity | 171 |
| Name | Agrp |
| Description | agouti related protein homolog (mouse) |
| Notes | This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq] |
| Pathway | melanocortin system pathway |
|---|
| GO Molecular Function | receptor binding |
|---|---|
| hormone activity | |
| neuropeptide hormone activity |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space |
| GO Biological Process | adult feeding behavior |
|---|---|
| hormone-mediated signaling pathway | |
| feeding behavior | |
| response to insulin stimulus | |
| eating behavior | |
| neuropeptide signaling pathway |
| Ariadne Ontology | agouti |
|---|
| Group | agouti |
|---|---|
| extracellular region | |
| adult feeding behavior | |
| hormone-mediated signaling pathway | |
| feeding behavior | |
| response to insulin stimulus | |
| eating behavior | |
| neuropeptide signaling pathway | |
| receptor binding | |
| hormone activity | |
| neuropeptide hormone activity | |
| extracellular space |
| MedScan ID | 181 |
|---|
| Hugo ID | 330 |
|---|
| Human chromosome position | 16q22 |
|---|
| LocusLink ID | 181 |
|---|---|
| 11604 | |
| 25582 |
| Alias | ART |
|---|---|
| AGRT | |
| ASIP2 | |
| MGC118963 | |
| agouti-related protein | |
| orexigenic neuropeptide | |
| agouti related protein | |
| AGRP | |
| agouti (mouse) related protein | |
| agouti related protein homolog | |
| agouti related protein homolog (mouse) | |
| agouti related protein homolog isoform 1 | |
| agouti related protein homolog isoform 2 | |
| agouti related protein homolog isoform I | |
| agouti related protein homolog isoform II | |
| Agouti-related transcript | |
| homolog of Agouti-related transcript | |
| homolog of mouse Agouti-related transcript | |
| mouse homolog of Agouti-related transcript |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602311 |
|---|---|
| 601665 |
| Mouse chromosome position | 8 |
|---|
| GO ID | 0005184 |
|---|---|
| 0005102 | |
| 0008343 | |
| 0042755 | |
| 0007631 | |
| 0009755 | |
| 0007218 | |
| 0032868 | |
| 0005576 | |
| 0005179 | |
| 0005615 |
| Rat chromosome position | 19q11 |
|---|
| Swiss-Prot Accession | C6SUN5 |
|---|---|
| O00253 | |
| P56473 | |
| Q3UU47 | |
| Q5J6B1 | |
| Q9QXJ3 | |
| O35967 | |
| O15459 | |
| Q2TBD9 |
| Unigene ID | Hs.104633 |
|---|---|
| Mm.441696 | |
| Rn.137597 |
| KEGG ID | hsa:181 |
|---|---|
| mmu:11604 | |
| rno:25582 |
| Swiss-Prot ID | AGRP_MOUSE |
|---|---|
| AGRP_HUMAN | |
| Q3UU47_MOUSE | |
| C6SUN5_HUMAN |
| Cell Localization | Secreted |
|---|---|
| Extracellular |
| IPI ID | IPI00113784 |
|---|---|
| IPI00010869 | |
| IPI00213212 |
| Homologene ID | 7184 |
|---|
| RGD ID | 2068 |
|---|
| MGI ID | 892013 |
|---|