Ariadne Genomics Inc. immunomodulation energy homeostasis cortisol biosynthetic pathway protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphas family Mgrn1 HPA axis POMC processing enzymes MSH peptides stress conditions --+> corticotropin-releasing hormone signaling pathway stress conditions Pomc ---> MSH peptides Atrn corticotropin-releasing hormone signaling pathway MRAP2 Pomc ---> ACTH Agrp Pomc corticotropin-releasing hormone signaling pathway --+> Pomc Gnas Mgrn1 ---| MC1R Mrap --+> Mc2r MC1R ---> melanogenesis melanogenesis steroidogenesis Asip ---| MC1R ACTH ---- Mc3r ACTH ---- MC1R ACTH ---- Mc5r ACTH Mc3r ---> immunomodulation Mc3r Mc3r ---> energy homeostasis Mc4r ---> energy homeostasis Asip ---- Atrn Agrp ---| Mc4r Agrp ---| Mc3r Agrp ---- Mc4r Agrp ---- Mc3r Gnas ---- Mc2r Gnas ---- MC1R Asip Mc2r Gnas ---- Mc3r Atrnl1 ---- Mc4r Mc4r Atrnl1 Mc5r Asip ---- MC1R Mc5r ---> immunomodulation Gnas ---- Mc4r cAMP --+> protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphas family --+> cAMP cAMP Gnas ---- Mc5r ACTH ---- Mc2r MC1R ---- MSH peptides Mc3r ---- MSH peptides Mc4r ---- MSH peptides Mc5r ---- MSH peptides ACTH ---- Mc4r Mc2r --+> cortisol biosynthetic pathway MC1R Mrap