| URN | urn:agi-llid:5770 |
|---|---|
| Connectivity | 341 |
| Name | Ptpn1 |
| Description | protein tyrosine phosphatase, non-receptor type 1 |
| Notes | protein-tyrosine-phosphatase which has only phosphotyrosine phosphatase activity [RGD] |
| Pathway | insulin signaling pathway |
|---|---|
| leptin system pathway | |
| insulin signaling pathway | |
| altered insulin signaling pathway | |
| leptin system pathway |
| GO Molecular Function | hydrolase activity |
|---|---|
| insulin receptor binding | |
| zinc ion binding | |
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein tyrosine phosphatase activity | |
| receptor activity |
| GO Cellular Component | membrane |
|---|---|
| insoluble fraction | |
| endoplasmic reticulum membrane | |
| cytoplasmic vesicle | |
| cytosol | |
| endoplasmic reticulum | |
| anchored to membrane |
| GO Biological Process | signal transduction |
|---|---|
| regulation of insulin receptor signaling pathway | |
| negative regulation of insulin receptor signaling pathway | |
| protein amino acid dephosphorylation | |
| dephosphorylation | |
| insulin receptor signaling pathway |
| Ariadne Ontology | INSR phosphatase |
|---|
| Group | INSR phosphatase |
|---|---|
| signal transduction | |
| regulation of insulin receptor signaling pathway | |
| negative regulation of insulin receptor signaling pathway | |
| protein amino acid dephosphorylation | |
| dephosphorylation | |
| insulin receptor signaling pathway | |
| hydrolase activity | |
| insulin receptor binding | |
| zinc ion binding | |
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein tyrosine phosphatase activity | |
| receptor activity | |
| membrane | |
| insoluble fraction | |
| endoplasmic reticulum membrane | |
| cytoplasmic vesicle | |
| cytosol | |
| endoplasmic reticulum | |
| anchored to membrane |
| MedScan ID | 5770 |
|---|
| Hugo ID | 9642 |
|---|
| Human chromosome position | 20q13.1-q13.2 |
|---|
| LocusLink ID | 5770 |
|---|---|
| 19246 | |
| 24697 | |
| 113993 | |
| 508658 | |
| 791969 |
| Alias | PTP1B |
|---|---|
| tyrosine-protein phosphatase non-receptor type 1 | |
| protein tyrosine phosphatase 1B | |
| protein-tyrosine phosphatase 1B | |
| protein tyrosine phosphatase, placental | |
| PTP-1B | |
| PTP-HA2 | |
| RP23-58A8.1 | |
| OTTMUSP00000017024 | |
| protein-tyrosine phosphatase HA2 | |
| protein-protein-tyrosine phosphatase HA2 | |
| Ptp | |
| MGC93562 | |
| LOC128529 | |
| non-receptor tyrosine phophatase 1 | |
| non-receptor tyrosine phophatase I | |
| non-receptor tyrosine phosphatase 1 | |
| non-receptor tyrosine phosphatase I | |
| OTTHUMP00000031266 | |
| Phosphotyrosine phosphatase 1b | |
| protein tyrosine phophatase 1B | |
| protein tyrosine phophatase, placental | |
| protein tyrosine phosphatase, non-receptor type | |
| protein tyrosine phosphatase, non-receptor type 1 | |
| protein tyrosine phosphatase, non-receptor type I | |
| PTP-1Bs | |
| Ptpn I | |
| Ptpn1 | |
| Tyrosine phosphatase 1 | |
| Tyrosine phosphatase I | |
| Protein-tyrosine phosphatase | |
| LOC791969 | |
| chromosome | |
| hypothetical protein LOC791969 | |
| scaffold |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 176885 |
|---|---|
| 125853 | |
| 609830 |
| Mouse chromosome position | 2 |
|---|---|
| 2 H3 |
| GO ID | 0016787 |
|---|---|
| 0005158 | |
| 0004725 | |
| 0008270 | |
| 0046627 | |
| 0006470 | |
| 0007165 | |
| 0031410 | |
| 0005829 | |
| 0005783 | |
| 0005789 | |
| 0005626 | |
| 0016020 | |
| 0016791 | |
| 0004721 | |
| 0004872 | |
| 0016311 | |
| 0008286 | |
| 0046626 | |
| 0031225 | |
| 0005515 | |
| 0005737 | |
| 0005625 | |
| 0016021 | |
| 0004727 |
| Rat chromosome position | 3q42 |
|---|
| Swiss-Prot Accession | A8K3M3 |
|---|---|
| P18031 | |
| Q96QT9 | |
| P35821 | |
| Q3TZW9 | |
| Q3T9Y9 | |
| Q3TB93 | |
| Q3UCZ5 | |
| P20417 | |
| Q60840 | |
| Q62131 | |
| Q64498 | |
| Q99JS1 | |
| Q5TGD8 | |
| Q9BQV9 | |
| Q9NQQ4 |
| PIR ID | A34845 |
|---|---|
| JN0317 | |
| A35992 |
| Unigene ID | Hs.417549 |
|---|---|
| Mm.277916 | |
| Rn.11317 | |
| Bt.9542 | |
| Dr.76595 |
| KEGG ID | hsa:5770 |
|---|---|
| mmu:19246 | |
| rno:24697 |
| EC Number | 3.1.3.48 |
|---|
| Swiss-Prot ID | PTN1_RAT |
|---|---|
| PTN1_MOUSE | |
| PTN1_HUMAN | |
| A8K3M3_HUMAN | |
| Q3TZW9_MOUSE |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Cytoplasm |
| IPI ID | IPI00199272 |
|---|---|
| IPI00123039 | |
| IPI00297261 | |
| IPI00816802 |
| Homologene ID | 2119 |
|---|
| RGD ID | 61965 |
|---|
| MGI ID | 97805 |
|---|
| Microarray ID | 94929_at |
|---|
| FunctionalClass | hydrolase |
|---|---|
| protein binding | |
| protein tyrosine phosphatase | |
| phosphoprotein phosphatase | |
| receptor | |
| insulin receptor binding | |
| prenylated protein tyrosine phosphatase | |
| phosphoric monoester hydrolase |
| Mus musculus Chromosome position | 2 H3 |
|---|
| Source | Curated |
|---|---|
| GO component | |
| ResNet | |
| RGD modified |
| KEGG pathway | Adherens junction |
|---|---|
| Insulin signaling pathway |
| Homo sapiens Chromosome position | 20q13.1-q13.2 |
|---|
| Bos taurus Chromosome position | 13 |
|---|
| Rattus norvegicus Chromosome position | 3q42 |
|---|