| URN | urn:agi-llid:3952 |
|---|---|
| Connectivity | 1709 |
| Name | Lep |
| Description | leptin |
| Notes | involved in regulation of body weight, and may have a role in angiogenesis [RGD] |
| Pathway | LeptinR -> ELK-SRF signaling |
|---|---|
| LeptinR -> STAT signaling | |
| leptin system pathway | |
| leptin system pathway |
| GO Molecular Function | hormone activity |
|---|---|
| cytokine activity | |
| growth factor activity | |
| peptide hormone receptor binding |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space |
| GO Biological Process | negative regulation of metabolic process |
|---|---|
| response to dietary excess | |
| hormone metabolic process | |
| regulation of metabolic process | |
| central nervous system neuron development | |
| positive regulation of myeloid cell differentiation | |
| adult feeding behavior | |
| regulation of intestinal cholesterol absorption | |
| ovulation from ovarian follicle | |
| signal transduction | |
| positive regulation of MAPKKK cascade | |
| regulation of insulin secretion | |
| JAK-STAT cascade | |
| cAMP-mediated signaling | |
| regulation of gluconeogenesis | |
| insulin secretion | |
| glucose metabolic process | |
| fatty acid catabolic process | |
| bile acid metabolic process | |
| energy reserve metabolic process | |
| leptin-mediated signaling pathway | |
| response to insulin stimulus | |
| negative regulation of appetite | |
| eating behavior | |
| regulation of steroid biosynthetic process | |
| lipid metabolic process | |
| cholesterol metabolic process | |
| intracellular signaling pathway |
| Ariadne Ontology | Cytokine |
|---|
| Group | Cytokine |
|---|---|
| extracellular region | |
| negative regulation of metabolic process | |
| response to dietary excess | |
| hormone metabolic process | |
| regulation of metabolic process | |
| central nervous system neuron development | |
| positive regulation of myeloid cell differentiation | |
| adult feeding behavior | |
| regulation of intestinal cholesterol absorption | |
| ovulation from ovarian follicle | |
| signal transduction | |
| positive regulation of MAPKKK cascade | |
| regulation of insulin secretion | |
| JAK-STAT cascade | |
| cAMP-mediated signaling | |
| regulation of gluconeogenesis | |
| insulin secretion | |
| glucose metabolic process | |
| fatty acid catabolic process | |
| bile acid metabolic process | |
| energy reserve metabolic process | |
| leptin-mediated signaling pathway | |
| response to insulin stimulus | |
| negative regulation of appetite | |
| eating behavior | |
| regulation of steroid biosynthetic process | |
| lipid metabolic process | |
| cholesterol metabolic process | |
| intracellular signaling pathway | |
| hormone activity | |
| cytokine activity | |
| growth factor activity | |
| peptide hormone receptor binding | |
| extracellular space |
| MedScan ID | 3952 |
|---|
| Hugo ID | 6553 |
|---|
| Human chromosome position | 7q31.3 |
|---|
| LocusLink ID | 3952 |
|---|---|
| 16846 | |
| 25608 | |
| 280836 |
| Alias | OB |
|---|---|
| OBS | |
| FLJ94114 | |
| leptin | |
| obese protein | |
| obesity factor | |
| obese, mouse, homolog of | |
| leptin (murine obesity homolog) | |
| leptin (obesity homolog, mouse) | |
| obese | |
| homolog of mouse obese | |
| Lep | |
| OB_HUMAN | |
| obesity (murine homolog, leptin) | |
| obesity gene lep | |
| obs cDNA | |
| obs gene | |
| obesity | |
| Obesity (murine homolog leptin) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus |
| OMIM ID | 164160 |
|---|
| Mouse chromosome position | 6 10.5 cM |
|---|
| GO ID | 0008083 |
|---|---|
| 0005179 | |
| 0051428 | |
| 0008343 | |
| 0008206 | |
| 0021954 | |
| 0008203 | |
| 0042755 | |
| 0006112 | |
| 0009062 | |
| 0006006 | |
| 0042445 | |
| 0033210 | |
| 0006629 | |
| 0032099 | |
| 0009892 | |
| 0001542 | |
| 0043410 | |
| 0045639 | |
| 0006111 | |
| 0050796 | |
| 0030300 | |
| 0050810 | |
| 0002021 | |
| 0032868 | |
| 0007165 | |
| 0005576 | |
| 0005615 | |
| 0030073 | |
| 0023034 | |
| 0019222 | |
| 0005125 | |
| 0007259 | |
| 0019933 | |
| 0005515 | |
| 0007242 | |
| 0007267 |
| Rat chromosome position | 4q22 |
|---|
| Swiss-Prot Accession | A4D0Y8 |
|---|---|
| P41159 | |
| Q4TVR7 | |
| Q6NT58 | |
| P41160 | |
| Q544U0 | |
| P50596 | |
| O15158 | |
| Q56A88 |
| PIR ID | PC4034 |
|---|---|
| S50863 | |
| A38952 | |
| I53166 |
| Unigene ID | Hs.194236 |
|---|---|
| Mm.277072 | |
| Rn.44444 | |
| Bt.1939 |
| KEGG ID | hsa:3952 |
|---|---|
| mmu:16846 | |
| rno:25608 |
| Swiss-Prot ID | LEP_RAT |
|---|---|
| LEP_MOUSE | |
| LEP_HUMAN | |
| Q544U0_MOUSE | |
| A4D0Y8_HUMAN |
| Cell Localization | Secreted |
|---|---|
| Extracellular |
| IPI ID | IPI00199521 |
|---|---|
| IPI00111526 | |
| IPI00012760 |
| Homologene ID | 193 |
|---|
| RGD ID | 3000 |
|---|
| MGI ID | 104663 |
|---|
| Microarray ID | 98443_at |
|---|---|
| 98444_g_at |
| FunctionalClass | growth factor |
|---|---|
| hormone | |
| protein binding | |
| cytokine |
| Mus musculus Chromosome position | 6 10.5 cM |
|---|
| Source | Curated |
|---|---|
| GO component | |
| ResNet | |
| RGD modified |
| KEGG pathway | Cytokine-cytokine receptor interaction |
|---|---|
| Jak-STAT signaling pathway | |
| Neuroactive ligand-receptor interaction | |
| Adipocytokine signaling pathway |
| Homo sapiens Chromosome position | 7q31.3 |
|---|
| Bos taurus Chromosome position | 4q32 |
|---|
| Rattus norvegicus Chromosome position | 4q22 |
|---|