| URN | urn:agi-llid:3953 |
|---|---|
| Connectivity | 270 |
| Name | Lepr |
| Description | leptin receptor |
| Notes | receptor for leptin; may have a role in body weight maintainence [RGD] |
| Pathway | LeptinR -> ELK-SRF signaling |
|---|---|
| LeptinR -> STAT signaling | |
| leptin system pathway | |
| leptin system pathway |
| GO Molecular Function | peptide hormone binding |
|---|---|
| cytokine receptor activity | |
| receptor activity | |
| transmembrane receptor activity | |
| protein-hormone receptor activity |
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| extracellular space | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | multicellular organismal development |
|---|---|
| female pregnancy | |
| regulation of metabolic process | |
| response to chemical stimulus | |
| angiogenesis | |
| ovulation from ovarian follicle | |
| signal transduction | |
| generation of precursor metabolites and energy | |
| cellular response to nutrient levels | |
| positive regulation of MAPKKK cascade | |
| energy reserve metabolic process | |
| leptin-mediated signaling pathway | |
| response to nicotine | |
| response to estrogen stimulus | |
| eating behavior | |
| cholesterol metabolic process | |
| cell surface receptor linked signaling pathway | |
| negative regulation of hydrolase activity |
| Ariadne Ontology | CytokineR |
|---|
| Group | CytokineR |
|---|---|
| extracellular region | |
| multicellular organismal development | |
| female pregnancy | |
| regulation of metabolic process | |
| response to chemical stimulus | |
| angiogenesis | |
| ovulation from ovarian follicle | |
| signal transduction | |
| generation of precursor metabolites and energy | |
| cellular response to nutrient levels | |
| positive regulation of MAPKKK cascade | |
| energy reserve metabolic process | |
| leptin-mediated signaling pathway | |
| response to nicotine | |
| response to estrogen stimulus | |
| eating behavior | |
| cholesterol metabolic process | |
| cell surface receptor linked signaling pathway | |
| negative regulation of hydrolase activity | |
| peptide hormone binding | |
| cytokine receptor activity | |
| receptor activity | |
| transmembrane receptor activity | |
| protein-hormone receptor activity | |
| membrane | |
| extracellular space | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 3953 |
|---|
| Hugo ID | 6554 |
|---|
| Human chromosome position | 1p31 |
|---|
| LocusLink ID | 3953 |
|---|---|
| 16847 | |
| 24536 | |
| 497205 | |
| 281279 | |
| 567241 |
| Alias | OBR |
|---|---|
| CD295 | |
| leptin receptor | |
| OB-R | |
| LEP-R | |
| huB219 | |
| OB receptor | |
| OTTHUMP00000010694 | |
| db | |
| obl | |
| Leprb | |
| Modb1 | |
| LEPROT | |
| OB-RGRP | |
| diabetes | |
| MGC105189 | |
| obese-like | |
| RP23-31K16.2 | |
| B219 | |
| OTTMUSP00000008795 | |
| leptin receptor gene-related protein | |
| Fa | |
| Leptin receptor (fatty) | |
| B219/OB-R | |
| LEPR | |
| LEPR_HUMAN | |
| Leptin receptors | |
| OB receptors | |
| OB-R/B219 | |
| OB-Ra | |
| OB-RGRPs | |
| OB-Rs | |
| OTTHUMP00000010693 | |
| LOC567241 | |
| chromosome | |
| scaffold | |
| similar to class I helical cytokine receptor number 30 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 601007 |
|---|
| Mouse chromosome position | 4 46.7 cM |
|---|
| GO ID | 0004896 |
|---|---|
| 0017046 | |
| 0016500 | |
| 0004888 | |
| 0001525 | |
| 0007166 | |
| 0031669 | |
| 0008203 | |
| 0042755 | |
| 0006112 | |
| 0007565 | |
| 0033210 | |
| 0007275 | |
| 0051346 | |
| 0001542 | |
| 0043410 | |
| 0042221 | |
| 0043627 | |
| 0035094 | |
| 0005576 | |
| 0005615 | |
| 0016021 | |
| 0005886 | |
| 0004872 | |
| 0019222 | |
| 0007165 | |
| 0005887 | |
| 0016020 | |
| 0006091 | |
| 0005515 |
| Rat chromosome position | 5q33 |
|---|
| Swiss-Prot Accession | P48357 |
|---|---|
| Q4G138 | |
| P48356 | |
| Q3US58 | |
| Q640Q2 | |
| Q3UNU8 | |
| A2AV69 | |
| Q62959 | |
| Q9JHF4 | |
| O35686 | |
| O54986 | |
| Q61215 | |
| Q64309 | |
| Q9QWG3 | |
| Q9QWV5 | |
| O35772 | |
| O35773 | |
| O54805 | |
| P70493 | |
| P70494 | |
| P70495 | |
| P97589 | |
| Q62960 | |
| Q63007 | |
| Q63385 | |
| Q63386 | |
| Q9ERI4 | |
| Q13592 | |
| Q13593 | |
| Q13594 | |
| Q92919 | |
| Q92920 | |
| Q92921 |
| PIR ID | S68437 |
|---|---|
| S68438 | |
| S68439 | |
| S68440 | |
| S68441 | |
| JC4895 | |
| S74225 |
| Unigene ID | Hs.23581 |
|---|---|
| Hs.723178 | |
| Mm.259282 | |
| Rn.9891 | |
| Hs.705413 | |
| Rn.144583 | |
| Bt.52532 | |
| Dr.115303 |
| KEGG ID | hsa:3953 |
|---|---|
| mmu:16847 | |
| rno:24536 |
| Swiss-Prot ID | LEPR_MOUSE |
|---|---|
| LEPR_RAT | |
| LEPR_HUMAN | |
| Q3UNU8_MOUSE | |
| Q640Q2_MOUSE | |
| A2AV69_MOUSE | |
| Q3US58_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Secreted | |
| Plasma membrane |
| IPI ID | IPI00229997 |
|---|---|
| IPI00229998 | |
| IPI00229999 | |
| IPI00230000 | |
| IPI00230203 | |
| IPI00210294 | |
| IPI00231373 | |
| IPI00231375 | |
| IPI00231376 | |
| IPI00390901 | |
| IPI00009243 | |
| IPI00219708 | |
| IPI00219709 | |
| IPI00219710 | |
| IPI00219711 | |
| IPI00828591 | |
| IPI00873026 | |
| IPI00567132 |
| Homologene ID | 1731 |
|---|
| RGD ID | 3001 |
|---|
| MGI ID | 104993 |
|---|
| Microarray ID | 100430_at |
|---|---|
| 100431_at |
| FunctionalClass | hematopoietin/interferon-class (D200-domain) cytokine receptor |
|---|---|
| protein binding | |
| receptor | |
| transmembrane receptor | |
| peptide hormone binding | |
| protein-hormone receptor |
| Mus musculus Chromosome position | 4 46.7 cM |
|---|
| Source | Curated |
|---|---|
| GO component | |
| ResNet | |
| RGD modified |
| KEGG pathway | Adipocytokine signaling pathway |
|---|---|
| Cytokine-cytokine receptor interaction | |
| Jak-STAT signaling pathway | |
| Neuroactive ligand-receptor interaction |
| Homo sapiens Chromosome position | 1p31 |
|---|
| Bos taurus Chromosome position | 3q33 |
|---|
| Rattus norvegicus Chromosome position | 5q33 |
|---|