| URN | urn:agi-Binding:inout-urn:agi-llid:4903:inout-urn:agi-llid:3717::unknown |
|---|---|
| References | 25 |
| Connectivity | 2 |
| Effect | unknown |
| TextRef | info:pmid/17021051#abs:4 |
|---|---|
| MedLine Reference | 17021051:3 |
| Sentence | In basal conditions, JAK2 forms a multimeric complex with SHP-2, Src and PTPeta. |
| CellLineName | K1 |
| Tissue | egg |
| TextRef | info:pmid/17027227#abs:6 |
|---|---|
| MedLine Reference | 17027227:5 |
| Sentence | We found that the N-terminal SH2 domain of SHP-2 binds Jak2 predominantly, but not exclusively at tyrosine 201. |
| CellType | fibroblast |
| TextRef | info:pmid/8995399#abs:7 |
|---|---|
| MedLine Reference | 8995399:6 |
| Sentence | Finally, deletion of the N terminus but not the kinase-like domain of JAK2 abolishes the association of JAK2 with SHP-2. |
| CellLineName | COS I |
| TextRef | info:pmid/8598196#abs:3 |
|---|---|
| MedLine Reference | 8598196:2 |
| Sentence | The formation of the trimeric PRLR-Jak2-PTP1D complex is critical for transmission of a lactogenic signal, while PTP1D phosphorylation is necessary, but not sufficient. |
| TextRef | info:pmid/11032244#abs:5 |
|---|---|
| MedLine Reference | 11032244:4 |
| Sentence | In the dexamethasone-treated group, the JAK2 protein concentrations increased but the stoichiometry of its phosphorylation decreased to 20%, whereas the JAK2/STAT1 and JAK2/SHP2 associations changed by 70% and 170%, respectively. |
| Organ | Heart |
| TextRef | info:pmid/8598196#abs:2 |
|---|---|
| MedLine Reference | 8598196:1 |
| Sentence | We report that PTP1D, a cytoplasmic protein tyrosine phosphatase containing two Src homology 2 (SH2) domains, physically associates with the PRLR-Jak2 complex and is tyrosine-phosphorylated upon stimulation with prolactin. |
| TextRef | info:pmid/11032244#abs:6 |
|---|---|
| MedLine Reference | 11032244:5 |
| Sentence | In fasting and dexamethasone-treated rats, therefore, insulin-induced JAK2 tyrosine phosphorylation decreases, and the JAK2 protein expression is differentially regulated such that the insulin-induced JAK2 association with SHP2 and STAT1 shows opposite interactions with the kinase. |
| Organ | Heart |
| TextRef | info:pmid/8995399 |
|---|---|
| MedLine Reference | 8995399 |
| Source | Entrez Gene |
| TextRef | info:pmid/10976913#cont:185 |
|---|---|
| MedLine Reference | 10976913:10184 |
| Organism | Mus musculus |
| Journal | Mol. Endocrin |
| Journal Reference | v14 i9 p1338 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/14/9/1338 |
| TextRef | info:pmid/9544991#cont:214 |
|---|---|
| MedLine Reference | 9544991:10213 |
| Journal | Mol. Endocrin |
| Journal Reference | v12 i4 p556 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/12/4/556 |
| TextRef | info:pmid/9507023#cont:189 |
|---|---|
| MedLine Reference | 9507023:10188 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v273 i12 p7112 |
| Journal Link | http://www.jbc.org/cgi/content/full/273/12/7112 |
| TextRef | info:pmid/8978300#cont:216 |
|---|---|
| MedLine Reference | 8978300:10215 |
| Journal | Blood |
| Journal Reference | v89 i1 p261 |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/89/1/261 |
| TextRef | info:pmid/12270932#cont:314 |
|---|---|
| MedLine Reference | 12270932:10313 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i49 p47572 |
| Journal Link | http://www.jbc.org/cgi/content/full/277/49/47572 |
| TextRef | info:pmid/9442080#cont:309 |
|---|---|
| MedLine Reference | 9442080:10308 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v273 i4 p2344 |
| Journal Link | http://www.jbc.org/cgi/content/full/273/4/2344 |
| TextRef | info:pmid/10993888#cont:264 |
|---|---|
| MedLine Reference | 10993888:10263 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v275 i50 p39718 |
| Journal Link | http://www.jbc.org/cgi/content/full/275/50/39718 |
| TextRef | info:pmid/11152671#cont:145 |
|---|---|
| MedLine Reference | 11152671:10144 |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i14 p10839 |
| Journal Link | http://www.jbc.org/cgi/content/full/276/14/10839 |
| TextRef | info:pmid/9162089#cont:210 |
|---|---|
| MedLine Reference | 9162089:10209 |
| Journal | J. Biol. Chem |
| Journal Reference | v272 i22 p14470 |
| Journal Link | http://www.jbc.org/cgi/content/full/272/22/14470 |
| TextRef | info:pmid/9670943#cont:224 |
|---|---|
| MedLine Reference | 9670943:10223 |
| Organism | Mus musculus |
| Journal | J. Immunol |
| Journal Reference | v161 i2 p684 |
| Journal Link | http://www.jimmunol.org/cgi/content/full/161/2/684 |
| TextRef | info:pmid/9814969#cont:42 |
|---|---|
| MedLine Reference | 9814969:10041 |
| Organism | Mus musculus |
| Journal | Cell Phys |
| Journal Reference | v275 i5 pC1216 |
| Journal Link | http://ajpcell.physiology.org/cgi/content/full/275/5/C1216 |
| TextRef | info:pmid/10842184#cont:178 |
|---|---|
| MedLine Reference | 10842184:10177 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v275 i36 p28222 |
| Journal Link | http://www.jbc.org/cgi/content/full/275/36/28222 |
| TextRef | info:pmid/11435425#cont:257 |
|---|---|
| MedLine Reference | 11435425:10256 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i35 p32704 |
| Journal Link | http://www.jbc.org/cgi/content/full/276/35/32704 |
| TextRef | info:pmid/11054408#cont:144 |
|---|---|
| MedLine Reference | 11054408:10143 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i4 p2494 |
| Journal Link | http://www.jbc.org/cgi/content/full/276/4/2494 |
| TextRef | info:pmid/14634121#cont:192 |
|---|---|
| MedLine Reference | 14634121:10191 |
| Organism | Rattus norvegicus |
| Journal | J. Immunol |
| Journal Reference | v171 i11 p6072 |
| Journal Link | http://www.jimmunol.org/cgi/content/full/171/11/6072 |
| TextRef | info:pmid/9488469#cont:251 |
|---|---|
| MedLine Reference | 9488469:10250 |
| Organism | Rattus norvegicus |
| TextRef | info:pmid/11248703#cont:185 |
|---|---|
| MedLine Reference | 11248703:10184 |
| Journal | Eur. J. Biochem |
| Journal Reference | v268 i6 p1828 |
| Journal Link | http://www.ejbiochem.org/cgi/content/full/268/6/1828 |