| URN | urn:agi-Binding:inout-urn:agi-llid:3953:inout-urn:agi-llid:3952::unknown |
|---|---|
| References | 47 |
| Connectivity | 2 |
| Effect | unknown |
| TextRef | info:pmid/15254881#abs:2 |
|---|---|
| MedLine Reference | 15254881:1 |
| Sentence | One of the leptin receptor isoforms exists in a circulating soluble form that can bind leptin. |
| TextRef | info:pmid/12075576#abs:3 |
|---|---|
| MedLine Reference | 12075576:2 |
| Sentence | One of the leptin receptor isoforms exists in a circulating soluble form that can bind leptin. |
| TextRef | info:pmid/17590101#abs:4 |
|---|---|
| MedLine Reference | 17590101:3 |
| Sentence | However, the exact mechanism resulting form the interaction between leptin and leptin receptor has never been clarified. |
| TextRef | info:pmid/10449753#abs:3 |
|---|---|
| MedLine Reference | 10449753:2 |
| Sentence | Leptin binding to the Ob-Rb form of the leptin receptor leads to tyrosyl phosphorylation of the cytoplasmic domain of its receptor. |
| TextRef | info:pmid/17590101#abs:5 |
|---|---|
| MedLine Reference | 17590101:4 |
| Sentence | Here, the author used a new gene ontology technology to predict the molecular function and biological process due to the interaction between leptin and leptin receptor. |
| TextRef | info:pmid/8895396#abs:3 |
|---|---|
| MedLine Reference | 8895396:2 |
| Sentence | Transfected fa OB-R bound leptin with equal affinity to that of wild type OB-R. fa OB-R abundance was about 7 fold reduced compared to control cells. |
| Organism | Mus musculus |
| TextRef | info:pmid/12206874#abs:9 |
|---|---|
| MedLine Reference | 12206874:8 |
| Sentence | These data indicate that leptin binds the bovine leptin receptor with high affinity and that a pool of leptin is bound to abundant cell membrane-associated proteins. |
| Organism | Mus musculus |
| TextRef | info:pmid/14698207#abs:1 |
|---|---|
| MedLine Reference | 14698207:0 |
| Sentence | The biological actions of leptin on target tissues are mediated via several isoforms of receptors (Ob-Rs), which may differently interact with native leptin and its fragments. |
| TextRef | info:pmid/8895396#abs:2 |
|---|---|
| MedLine Reference | 8895396:1 |
| Sentence | We demonstrate that leptin binding to OB-R stimulates formation of STAT-1 and STAT-3 complexes, thereby defining transcriptional motifs for genes that are under leptin control. |
| TextRef | info:pmid/17556363#abs:10 |
|---|---|
| MedLine Reference | 17556363:9 |
| Sentence | These high levels of circulating leptin receptor bind leptin and likely alter its clearance, but do not inhibit leptin action and may actually potentiate leptin action. |
| Organ | Liver |
| TextRef | info:pmid/14654985#abs:1 |
|---|---|
| MedLine Reference | 14654985:0 |
| Sentence | Leptin, an adipose tissue-secreted hormone, acts via several isoforms of specific receptors (Ob-Rs), which may variously interact with the native leptin molecule and its fragments. |
| TextRef | info:pmid/17890170#abs:3 |
|---|---|
| MedLine Reference | 17890170:2 |
| Sentence | Leptin binding to the leptin-receptors on the surface of these neurons initiates intracellular signal transduction and activation of target genes, resulting in the synthesis and release of neuropeptides (POMC, CART) with anorectic effects. |
| CellType | neural |
| TextRef | info:pmid/8608603 |
|---|---|
| MedLine Reference | 8608603 |
| Source | Entrez Gene |
| TextRef | info:pmid/12649390#abs:4 |
|---|---|
| MedLine Reference | 12649390:3 |
| Organ | renal |
| Organism | Rattus norvegicus |
| TextRef | info:pmid/11406655#abs:2 |
|---|---|
| MedLine Reference | 11406655:1 |
| Organ | hypothalamic |
| TextRef | info:pmid/12897384#abs:3 |
|---|---|
| MedLine Reference | 12897384:2 |
| Tissue | endometrial |
| TextRef | info:pmid/15016839#abs:6 |
|---|---|
| MedLine Reference | 15016839:5 |
| Organ | Kidney |
| CellLineName | 293 |
| TextRef | info:pmid/10944457#abs:5 |
|---|---|
| MedLine Reference | 10944457:4 |
| CellType | adipocyte |
| TextRef | info:pmid/9218470#abs:7 |
|---|---|
| MedLine Reference | 9218470:6 |
| CellLineName | COS I |
| TextRef | info:pmid/12050276#abs:11 |
|---|---|
| MedLine Reference | 12050276:10 |
| Organism | Mus musculus |
| TextRef | info:pmid/15923664#cont:317 |
|---|---|
| MedLine Reference | 15923664:10316 |
| Journal | Cell Sci |
| Journal Reference | v118 i11 p2519 |
| Journal Link | http://jcs.biologists.org/cgi/content/full/118/11/2519 |
| TextRef | info:pmid/9231810#cont:141 |
|---|---|
| MedLine Reference | 9231810:10140 |
| Organism | Mus musculus |
| Journal | Endocrinology |
| Journal Reference | v138 i8 p3548 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/138/8/3548 |
| TextRef | info:pmid/9374549#cont:192 |
|---|---|
| MedLine Reference | 9374549:10191 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v272 i48 p30546 |
| Journal Link | http://www.jbc.org/cgi/content/full/272/48/30546 |
| TextRef | info:pmid/10491650#cont:192 |
|---|---|
| MedLine Reference | 10491650:10191 |
| Organism | Mus musculus |
| Journal | Biology of reproduction |
| Journal Reference | v61 i4 p1104 |
| Journal Link | http://www.biolreprod.org/cgi/content/full/61/4/1104 |
| TextRef | info:pmid/12734179#cont:50 |
|---|---|
| MedLine Reference | 12734179:10049 |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i29 p26604 |
| Journal Link | http://www.jbc.org/cgi/content/full/278/29/26604 |
| TextRef | info:pmid/9545355#cont:110 |
|---|---|
| MedLine Reference | 9545355:10109 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v273 i16 p10078 |
| Journal Link | http://www.jbc.org/cgi/content/full/273/16/10078 |
| TextRef | info:pmid/11259669#cont:135 |
|---|---|
| MedLine Reference | 11259669:10134 |
| Organism | Mus musculus |
| Journal | PNAS |
| Journal Reference | v98 i7 p4233 |
| Journal Link | http://www.pnas.org/cgi/content/full/98/7/4233 |
| TextRef | info:pmid/9463481#cont:147 |
|---|---|
| MedLine Reference | 9463481:10146 |
| Journal | Mol. Pharm |
| Journal Reference | v53 i2 p234 |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/53/2/234 |
| TextRef | info:pmid/14576185#cont:180 |
|---|---|
| MedLine Reference | 14576185:10179 |
| Organism | Mus musculus |
| Journal | Endocrinology |
| Journal Reference | v145 i2 p743 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/145/2/743 |
| TextRef | info:pmid/9786864#cont:111 |
|---|---|
| MedLine Reference | 9786864:10110 |
| TextRef | info:pmid/14522828#cont:137 |
|---|---|
| MedLine Reference | 14522828:10136 |
| Journal | Biology of reproduction |
| Journal Reference | v70 i1 p229 |
| Journal Link | http://www.biolreprod.org/cgi/content/full/70/1/229 |
| TextRef | info:pmid/15677491#cont:214 |
|---|---|
| MedLine Reference | 15677491:10213 |
| Organism | Rattus norvegicus |
| Journal | Diabetes |
| Journal Reference | v54 i2 p348 |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/54/2/348 |
| TextRef | info:pmid/9660803#cont:297 |
|---|---|
| MedLine Reference | 9660803:10296 |
| Organism | Rattus norvegicus |
| TextRef | info:pmid/14525952#cont:187 |
|---|---|
| MedLine Reference | 14525952:10186 |
| Organism | Mus musculus |
| Journal | Mol. Endocrin |
| Journal Reference | v18 i1 p150 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/18/1/150 |
| TextRef | info:pmid/15644325#cont:43 |
|---|---|
| MedLine Reference | 15644325:10042 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
| Journal Reference | v280 i11 p10034 |
| Journal Link | http://www.jbc.org/cgi/content/full/280/11/10034 |
| TextRef | info:pmid/12665505#cont:290 |
|---|---|
| MedLine Reference | 12665505:10289 |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i24 p21920 |
| Journal Link | http://www.jbc.org/cgi/content/full/278/24/21920 |
| TextRef | info:pmid/12606446#cont:206 |
|---|---|
| MedLine Reference | 12606446:10205 |
| Organism | Rattus norvegicus |
| Journal | Biology of reproduction |
| Journal Reference | v68 i4 p1199 |
| Journal Link | http://www.biolreprod.org/cgi/content/full/68/4/1199 |
| TextRef | info:pmid/10428856#cont:265 |
|---|---|
| MedLine Reference | 10428856:10264 |
| Journal | J. Biol. Chem |
| Journal Reference | v274 i32 p22729 |
| Journal Link | http://www.jbc.org/cgi/content/full/274/32/22729 |
| TextRef | info:pmid/9608004#cont:189 |
|---|---|
| MedLine Reference | 9608004:10188 |
| Organism | Mus musculus |
| Journal | Reg.Int.Comp.Phys |
| Journal Reference | v274 i6 pR1518 |
| Journal Link | http://ajpregu.physiology.org/cgi/content/full/274/6/R1518 |
| TextRef | info:pmid/12193402#cont:124 |
|---|---|
| MedLine Reference | 12193402:10123 |
| Journal | Biology of reproduction |
| Journal Reference | v67 i3 p911 |
| Journal Link | http://www.biolreprod.org/cgi/content/full/67/3/911 |
| TextRef | info:pmid/10508193#cont:269 |
|---|---|
| MedLine Reference | 10508193:10268 |
| Journal | Lipid Res |
| Journal Reference | v40 i10 p1735 |
| Journal Link | http://www.jlr.org/cgi/content/full/40/10/1735 |
| TextRef | info:pmid/9950766#cont:41 |
|---|---|
| MedLine Reference | 9950766:10040 |
| Organism | Mus musculus |
| Journal | Cell Phys |
| Journal Reference | v276 i2 pC386 |
| Journal Link | http://ajpcell.physiology.org/cgi/content/full/276/2/C386 |
| TextRef | info:pmid/9681499#cont:181 |
|---|---|
| MedLine Reference | 9681499:10180 |
| Organism | Rattus norvegicus |
| Journal | Endocrinology |
| Journal Reference | v139 i8 p3485 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/8/3485 |
| TextRef | info:pmid/15539553#cont:62 |
|---|---|
| MedLine Reference | 15539553:10061 |
| Organism | Mus musculus |
| Journal | Endocrinology |
| Journal Reference | v146 i2 p694 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/146/2/694 |
| TextRef | info:pmid/12970164#cont:177 |
|---|---|
| MedLine Reference | 12970164:10176 |
| Journal | Endocrinology |
| Journal Reference | v144 i12 p5595 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/144/12/5595 |
| TextRef | info:pmid/10098497#cont:262 |
|---|---|
| MedLine Reference | 10098497:10261 |
| Journal | Endocrinology |
| Journal Reference | v140 i4 p1630 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/140/4/1630 |
| TextRef | info:pmid/12270921#cont:195 |
|---|---|
| MedLine Reference | 12270921:10194 |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i48 p45898 |
| Journal Link | http://www.jbc.org/cgi/content/full/277/48/45898 |