| URN | urn:agi-ProtModification:inout-urn:agi-llid:5770:out-urn:agi-llid:6774::negative:dephosphorylation |
|---|---|
| References | 6 |
| Connectivity | 2 |
| Effect | negative |
| Mechanism | dephosphorylation |
| Original # of References | 6 |
| TextRef | info:pmid/12354677#abs:6 |
|---|---|
| PubYear | 2002 |
| MedlineTA | Mol Cell Endocrinol |
| MedLine Reference | 12354677:5 |
| Sentence | Over-expression of PTP1B in GT1-7 cells resulted in a dose-dependent decrease in endogenous JAK2 and STAT3 tyrosine phosphorylation compared with cells transfected with lepR alone. |
| Organ | hypothalamus |
| Organism | Mus musculus |
| TextRef | info:pmid/15821101#abs:7 |
|---|---|
| PubYear | 2005 |
| MedlineTA | J Mol Endocrinol |
| MedLine Reference | 15821101:6 |
| Sentence | PTP1B was able to dephosphorylate activated JAK2 and STAT3 in vitro, whereas either no or a minimal effect was observed with cluster of differentiation 45 (CD45), PTPalpha and leukocyte antigen-related . |
| TextMods | 202: '(LAR)' -> '' |
| TextRef | info:pmid/16319070#abs:10 |
|---|---|
| PubYear | 2006 |
| MedlineTA | J Biol Chem |
| MedLine Reference | 16319070:9 |
| Sentence | Knockdown of STAT3 by STAT3-small interfering RNA negated the inhibitory effect of protein-tyrosine phosphatase inhibitor on troglitazone, indicating that troglitazone uses a STAT3 inactivation mechanism that makes caspase-8/9 activities susceptible to cytotoxic agents in glioma cells and that PTP1B plays a critical role in the down-regulation of activated STAT3, as well as FLIP and Bcl-2. |
| TextMods | 83: 'PTP ' -> 'protein-tyrosine phosphatase ' |
| TextRef | info:pmid/11970889#body:133 |
|---|---|
| PubYear | 2002 |
| MedlineTA | Dev Cell |
| MedLine Reference | 11970889:1132 |
| Sentence | There, PTP1B dephosphorylates Jak2, blocking the phosphorylation of the receptor and Stat3 (4). |
| CellType | Fibroblasts |
| TextRef | info:pmid/17083445#body:263 |
|---|---|
| PubYear | 2007 |
| MedlineTA | J Neurochem |
| MedLine Reference | 17083445:1262 |
| Sentence | Alternatively, PTP1B was shown to counteract efficiently leptin-signalling by dephosphorylation of STAT3 and JAK2 in vivo (Zabolotny et al. 2002). |
| CellType | Neurons |
| TextRef | info:pmid/12748279#body:247 |
|---|---|
| PubYear | 2003 |
| MedlineTA | Mol Cell Biol |
| MedLine Reference | 12748279:1246 |
| Sentence | Our data do not preclude the possibility that PTP-1B dephosphorylates other components of the growth hormone signaling pathway, such as the growth hormone receptor, STAT3, and STAT5. |
| CellLineName | H4IIE |
| TextMods | 94: 'GH ' -> 'growth hormone ' 140: 'GHR' -> 'growth hormone receptor' |