| URN | urn:agi-ProtModification:inout-urn:agi-llid:5770:out-urn:agi-llid:3717::negative:dephosphorylation |
|---|---|
| References | 15 |
| Connectivity | 2 |
| Effect | negative |
| Mechanism | dephosphorylation |
| Original # of References | 15 |
| TextRef | info:pmid/11970898#abs:4 |
|---|---|
| PubYear | 2002 |
| MedlineTA | Dev Cell |
| MedLine Reference | 11970898:3 |
| Sentence | In transfection studies, PTP1B dephosphorylates the leptin receptor-associated kinase, Jak2. |
| TextRef | info:pmid/18716132#abs:2 |
|---|---|
| PubYear | 2008 |
| MedlineTA | Blood |
| MedLine Reference | 18716132:1 |
| Sentence | PTP1B can modulate cytokine signaling pathways by dephosphorylating JAK2, TYK2, and STAT5a/b. |
| TextRef | info:pmid/15821101#abs:7 |
|---|---|
| PubYear | 2005 |
| MedlineTA | J Mol Endocrinol |
| MedLine Reference | 15821101:6 |
| Sentence | PTP1B was able to dephosphorylate activated JAK2 and STAT3 in vitro, whereas either no or a minimal effect was observed with cluster of differentiation 45 (CD45), PTPalpha and leukocyte antigen-related . |
| TextMods | 202: '(LAR)' -> '' |
| TextRef | info:pmid/12748279#body:463 |
|---|---|
| PubYear | 2003 |
| MedlineTA | Mol Cell Biol |
| MedLine Reference | 12748279:1462 |
| Sentence | PTP-1B dephosphorylates membrane-associated JAK2. |
| CellType | Fibroblasts |
| TextRef | info:pmid/11970889#body:133 |
|---|---|
| PubYear | 2002 |
| MedlineTA | Dev Cell |
| MedLine Reference | 11970889:1132 |
| Sentence | There, PTP1B dephosphorylates Jak2, blocking the phosphorylation of the receptor and Stat3 (4). |
| CellType | Fibroblasts |
| TextRef | info:pmid/20160350#body:223 |
|---|---|
| PubYear | 2010 |
| MedlineTA | J Clin Invest |
| MedLine Reference | 20160350:1222 |
| Sentence | PTP1B acts as a negative regulator of leptin signaling by directly dephosphorylating Jak2 (16-18). |
| Organ | nucleus infundibularis hypothalami |
| TextRef | info:pmid/16037128#body:275 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Mol Endocrinol |
| MedLine Reference | 16037128:1274 |
| Sentence | PTP1b interacts with JAK2 in a GH-dependent way and dephosphorylates the tyrosines present in the active JAK2 molecule. |
| Organ | Liver |
| TextRef | info:pmid/14693698#body:69 |
|---|---|
| PubYear | 2004 |
| MedlineTA | Diabetes |
| MedLine Reference | 14693698:1068 |
| Sentence | Ptp1b also inhibits leptin signaling by dephosphorylating Jak2, which decreases hypothalamic leptin sensitivity (16,17). |
| Organ | hypothalamus |
| TextRef | info:pmid/16505227#body:216 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Diabetes |
| MedLine Reference | 16505227:1215 |
| Sentence | PTP1B dephosphorylates and inactivates JAK2, the kinase responsible for tyrosine phosphorylation of the leptin receptor after leptin binding (11,12). |
| Organ | Coronary artery |
| TextRef | info:pmid/16098827#body:219 |
|---|---|
| PubYear | 2005 |
| MedlineTA | Cell Metab |
| MedLine Reference | 16098827:1218 |
| Sentence | Leptin signaling is negatively regulated by PTP1B, a protein tyrosine phosphatase that binds to and dephosphorylates JAK2 (Kaszubska et al., 2002 and Myers et al., 2001). |
| Organ | hypothalamus |
| TextRef | info:pmid/15561934#body:56 |
|---|---|
| PubYear | 2004 |
| MedlineTA | Diabetes |
| MedLine Reference | 15561934:1055 |
| Sentence | In both transfection studies and transgenic animals, it has been shown that PTP-1B dephosphorylates the leptin receptor, growth hormone, and interferon-γ receptor-associated kinase Jak2 (17-19). |
| TextRef | info:pmid/19372196#body:125 |
|---|---|
| PubYear | 2009 |
| MedlineTA | Endocrinology |
| MedLine Reference | 19372196:1124 |
| Sentence | Protein-tyrosine phosphatase IB (PTP1B) can dephosphorylate JAK2 and decrease leptin signaling in neurons, although its activity is not directly regulated by leptin action (4). |
| CellType | Neurons |
| TextRef | info:pmid/17038557#body:70 |
|---|---|
| PubYear | 2007 |
| MedlineTA | Endocrinology |
| MedLine Reference | 17038557:1069 |
| Sentence | PTP1B dephosphorylates Janus kinase 2 (Jak2), the initial kinase in the leptin receptor signal transduction pathway (16, 17, 18), and in cell culture PTP1B expression is inversely proportional to leptin sensitivity (16, 17, 19). |
| TextRef | info:pmid/19017730#body:64 |
|---|---|
| PubYear | 2009 |
| MedlineTA | Am J Physiol Endocrinol Metab |
| MedLine Reference | 19017730:1063 |
| Sentence | A direct link between PTP1B and leptin signaling was subsequently noted, based on evidence that PTP1B dephosphorylates Janus Kinase 2 (Jak2), the initial tyrosine kinase mediating leptin signaling (9, 28, 40) and that mice with whole body PTP1B deletion are hypersensitive to leptin (9, 19, 40). |
| TextRef | info:pmid/16269466#body:241 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Endocrinology |
| MedLine Reference | 16269466:1240 |
| Sentence | Because it was observed that PTP-1B negatively regulates leptin signaling by dephosphorylating Janus kinase-2 (31, 32), an alternative explanation for the hypersensitivity of phosphotyrosine phosphatase-1B-null mice to insulin, especially in the liver, is enhanced hepatic leptin signaling in this circumstance. |
| TextMods | 175: 'PTP' -> 'phosphotyrosine phosphatase' |
| Organ | Liver |