Ariadne Genomics Inc. PY1138 PY985 Stat3 Lepr --+> Jak2 Jak2 Lepr Ptpn11 Socs3 ---| Lepr Jak2 --+> Irs2 Lepr --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Lep phosphatidylinositol 3-kinase-Akt signaling pathway leptin activated Stat3 gene targets ---> Socs3 Socs3 Ptpn1 Lepr ---- Stat3 Lep ---- Lepr Jak2 --+> Lepr Jak2 --+> Irs1 Jak2 ---- Lepr Jak2 ---- Sh2bpsm1 Irs1 ---- Sh2bpsm1 Irs2 ---- Sh2bpsm1 Jak2 ---- Ptpn11 Lepr ---- Ptpn11 Stat3 ---> leptin activated Stat3 gene targets the extracellular signal-regulated Raf/Mek/Erk signaling pathway Ptpn1 ---| Stat3 Ptpn1 ---| Jak2 Irs2 Irs1 Sh2bpsm1 Jak-Stat signaling pathway Socs3 ---| Jak2 Jak2 --+> Stat3 leptin activated Stat3 gene targets Lepr --+> phosphatidylinositol 3-kinase-Akt signaling pathway Jak2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway