| URN | urn:agi-llid:10956 |
|---|---|
| Connectivity | 4 |
| Name | Os9 |
| Description | osteosarcoma amplified 9, endoplasmic reticulum lectin |
| Notes | This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] |
| Pathway | hypoxia inducible factor pathway |
|---|
| GO Molecular Function | glycoprotein binding |
|---|---|
| sugar binding |
| GO Cellular Component | endoplasmic reticulum |
|---|---|
| Hrd1p ubiquitin ligase complex | |
| endoplasmic reticulum lumen |
| GO Biological Process | protein ubiquitination |
|---|---|
| protein ubiquitination involved in ubiquitin-dependent protein catabolic process | |
| ER-associated protein catabolic process | |
| protein retention in ER lumen | |
| response to endoplasmic reticulum stress |
| Group | protein ubiquitination |
|---|---|
| protein ubiquitination involved in ubiquitin-dependent protein catabolic process | |
| ER-associated protein catabolic process | |
| protein retention in ER lumen | |
| response to endoplasmic reticulum stress | |
| glycoprotein binding | |
| sugar binding | |
| endoplasmic reticulum | |
| Hrd1p ubiquitin ligase complex | |
| endoplasmic reticulum lumen |
| MedScan ID | 10956 |
|---|
| Hugo ID | 16994 |
|---|
| Human chromosome position | 12q13 |
|---|
| LocusLink ID | 10956 |
|---|---|
| 216440 | |
| 362891 |
| Alias | OS-9 |
|---|---|
| ERLEC2 | |
| protein OS-9 | |
| erlectin 2 | |
| amplified in osteosarcoma 9 | |
| endoplasmic reticulum lectin 2 | |
| osteosarcoma amplified 9, endoplasmic reticulum associated protein | |
| AU022351 | |
| 4632413K17Rik | |
| osteosarcoma amplified 9 | |
| MGC94750 | |
| amplified in osteosarcoma | |
| 1300007E20 | |
| 4632413K17 | |
| amplified in osteosarcoma-9 | |
| OS IX | |
| osteosarcoma amplified 9, endoplasmic reticulum lectin |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 609677 |
|---|
| Mouse chromosome position | 10 |
|---|
| GO ID | 0001948 |
|---|---|
| 0005529 | |
| 0030433 | |
| 0006621 | |
| 0016567 | |
| 0042787 | |
| 0034976 | |
| 0000836 | |
| 0005783 | |
| 0005788 |
| Rat chromosome position | 7q22 |
|---|
| Swiss-Prot Accession | Q9BW99 |
|---|---|
| A6NLB2 | |
| Q13438 | |
| Q6IBL2 | |
| Q9BR60 | |
| Q8K2C7 | |
| Q922S5 | |
| Q5RKH6 | |
| A6NDD1 | |
| O00579 | |
| A6NFR7 | |
| Q8IZ58 |
| PIR ID | JC5889 |
|---|
| Unigene ID | Hs.527861 |
|---|---|
| Mm.295246 | |
| Rn.1579 |
| KEGG ID | hsa:10956 |
|---|---|
| mmu:216440 | |
| rno:362891 |
| Swiss-Prot ID | OS9_HUMAN |
|---|---|
| OS9_MOUSE | |
| OS9_RAT | |
| A6NLB2_HUMAN | |
| Q9BW99_HUMAN | |
| Q5RKH6_RAT | |
| Q8K2C7_MOUSE |
| Cell Localization | Endoplasmic reticulum lumen |
|---|
| IPI ID | IPI00329760 |
|---|---|
| IPI00398855 | |
| IPI00873981 | |
| IPI00230353 | |
| IPI00947566 | |
| IPI00366234 | |
| IPI00604451 | |
| IPI00186581 | |
| IPI00791882 | |
| IPI00784387 | |
| IPI00791303 | |
| IPI00793206 | |
| IPI00794458 | |
| IPI00795771 | |
| IPI00557716 |
| Homologene ID | 31409 |
|---|
| RGD ID | 1359574 |
|---|
| MGI ID | 1924301 |
|---|