Protein Egln2

URN	urn:agi-llid:54750
Connectivity	40
Name	Egln2
Description	egl nine homolog 2 (C. elegans)
Notes	The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]

Pathway	hypoxia inducible factor pathway

GO Molecular Function	oxidoreductase activity
	L-ascorbic acid binding
	oxygen sensor activity
	metal ion binding
	iron ion binding
	ferrous iron binding
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

GO Cellular Component	cytoplasm
	nucleus

GO Biological Process	oxidation reduction
	cell redox homeostasis
	regulation of cell growth
	response to hypoxia
	positive regulation of protein catabolic process
	estrogen receptor signaling pathway

Group	oxidation reduction
	cell redox homeostasis
	regulation of cell growth
	response to hypoxia
	positive regulation of protein catabolic process
	estrogen receptor signaling pathway
	oxidoreductase activity
	L-ascorbic acid binding
	oxygen sensor activity
	metal ion binding
	iron ion binding
	ferrous iron binding
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
	cytoplasm
	nucleus

MedScan ID	54750

Hugo ID	14660

Human chromosome position	19q13.2

Alias	EIT6
	PHD1
	HPH-3
	HIFPH1
	DKFZp434E026
	egl nine homolog 2
	HPH-1
	HIF-PH1
	estrogen-induced tag 6
	HIF prolyl hydroxylase 1
	HIF-prolyl hydroxylase 1
	hypoxia-inducible factor prolyl hydroxylase 1
	prolyl hydroxylase domain-containing protein 1
	Ier4
	SM-20
	C85656
	MGC101954
	0610011A13Rik
	falkor
	OTTMUSP00000026894
	OTTMUSP00000026895
	immediate early response 4
	PHD-1
	MGC93662
	MGC93666
	HIF-1alpha prolyl-4-hydroxylase-1
	0610011A13
	EGL nine (C.elegans) homolog
	EGL nine (C.elegans) homolog 2
	EGL nine (C.elegans) homolog 2 isoform 1
	EGL nine (C.elegans) homolog 2 isoform 2
	EGL nine (C.elegans) homolog 2 isoform 3
	EGL nine (C.elegans) homolog 2 isoform I
	EGL nine (C.elegans) homolog 2 isoform II
	EGL nine (C.elegans) homolog 2 isoform III
	EGL nine (C.elegans) homolog II
	egl nine homolog 2 (C. elegans)
	EGL nine homolog II
	EGLN2
	estrogen-induced tag VI
	HIFPH I
	HIF-prolyl hydroxylase I
	immediate early response IV
	LOC112527
	LOC115774
	LOC308456
	oestrogen-induced tag 6
	oestrogen-induced tag VI
	PHD I
	prolyl hydroxylase domain-containing protein I

OMIM ID	606424

Mouse chromosome position	7 7.0 cM

Rat chromosome position	1q21

EC Number	1.14.11.-

Cell Localization	Nucleus
	Cytoplasm

Homologene ID	14204

RGD ID	631376

MGI ID	1932287