| URN | urn:agi-llid:64344 |
|---|---|
| Connectivity | 27 |
| Name | Hif3a |
| Description | hypoxia inducible factor 3, alpha subunit |
| Notes | The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. At least three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | hypoxia inducible factor pathway |
|---|
| GO Molecular Function | transcription regulator activity |
|---|---|
| signal transducer activity | |
| transcription factor activity | |
| DNA binding | |
| specific RNA polymerase II transcription factor activity |
| GO Cellular Component | cytoplasm |
|---|---|
| nucleus |
| GO Biological Process | signal transduction |
|---|---|
| regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| response to hypoxia |
| Ariadne Ontology | PAS domain |
|---|
| Group | PAS domain |
|---|---|
| transcription regulator activity | |
| signal transduction | |
| regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| response to hypoxia | |
| signal transducer activity | |
| transcription factor activity | |
| DNA binding | |
| specific RNA polymerase II transcription factor activity | |
| cytoplasm | |
| nucleus |
| MedScan ID | 64344 |
|---|
| Hugo ID | 15825 |
|---|
| Human chromosome position | 19q13.32 |
|---|
| LocusLink ID | 64344 |
|---|---|
| 53417 | |
| 64345 |
| Alias | IPAS |
|---|---|
| MOP7 | |
| PASD7 | |
| HIF-3A | |
| HIF-3A2 | |
| HIF-3A4 | |
| bHLHe17 | |
| hypoxia-inducible factor 3-alpha | |
| HIF3-alpha | |
| HIF-3-alpha | |
| HIF3-alpha-1 | |
| OTTHUMP00000180609 | |
| member of PAS protein 7 | |
| inhibitory PAS domain protein | |
| PAS domain-containing protein 7 | |
| hypoxia-inducible factor-3 alpha 4 | |
| basic-helix-loop-helix-PAS protein MOP7 | |
| class E basic helix-loop-helix protein 17 | |
| NEPAS | |
| OTTMUSP00000026202 | |
| neonatal and embryonic PAS | |
| hypoxia inducible factor three alpha | |
| HIF-3 alpha | |
| HIF3 alpha 1 | |
| hypoxia inducible factor 3a | |
| hypoxia inducible factor 3 alpha | |
| hypoxia-inducible factor 3 alpha | |
| FLJ14033 | |
| Hif3a | |
| hypoxia inducible factor 3, alpha subunit | |
| hypoxia-inducible factor-3 alpha isoform a | |
| hypoxia-inducible factor-3 alpha isoform b | |
| hypoxia-inducible factor-3 alpha isoform c | |
| hypoxia-inducible factor-3 alpha isoform d | |
| hypoxia-inducible factor-3 alpha IV |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 609976 |
|---|
| Mouse chromosome position | 7 |
|---|
| GO ID | 0004871 |
|---|---|
| 0003700 | |
| 0006355 | |
| 0001666 | |
| 0006366 | |
| 0005737 | |
| 0005634 | |
| 0003677 | |
| 0003704 | |
| 0030528 | |
| 0045944 | |
| 0045449 | |
| 0007165 | |
| 0006350 |
| Rat chromosome position | 1q21 |
|---|
| Swiss-Prot Accession | Q9Y2N7 |
|---|---|
| O95262 | |
| Q9HAM5 | |
| Q9UPH7 | |
| Q0VBL6 | |
| Q8R4D6 | |
| Q8R4D7 | |
| Q9JHS2 | |
| Q58A43 | |
| Q66K72 | |
| Q8WXA1 | |
| Q96K34 | |
| Q9H7Z9 | |
| Q9HAI2 |
| PIR ID | JC7771 |
|---|
| Unigene ID | Hs.420830 |
|---|---|
| Mm.135110 | |
| Rn.161814 |
| KEGG ID | hsa:64344 |
|---|---|
| mmu:53417 | |
| rno:64345 |
| Swiss-Prot ID | HIF3A_RAT |
|---|---|
| HIF3A_HUMAN | |
| HIF3A_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00199807 |
|---|---|
| IPI00164458 | |
| IPI00292048 | |
| IPI00470784 | |
| IPI00746815 | |
| IPI00844043 | |
| IPI00844320 | |
| IPI00738729 | |
| IPI00386973 | |
| IPI00795712 | |
| IPI00131181 | |
| IPI00621179 | |
| IPI00857168 |
| Homologene ID | 9646 |
|---|
| RGD ID | 70332 |
|---|
| MGI ID | 1859778 |
|---|