| URN | urn:agi-llid:2034 |
|---|---|
| Connectivity | 296 |
| Name | Epas1 |
| Description | endothelial PAS domain protein 1 |
| Notes | This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq] |
| Pathway | hypoxia inducible factor pathway |
|---|
| GO Molecular Function | transcription regulator activity |
|---|---|
| signal transducer activity | |
| transcription factor activity | |
| transcription factor binding | |
| DNA binding | |
| histone acetyltransferase binding | |
| protein heterodimerization activity | |
| transcription coactivator activity | |
| sequence-specific DNA binding | |
| RNA polymerase II transcription factor activity, enhancer binding | |
| specific RNA polymerase II transcription factor activity |
| GO Cellular Component | cytoplasm |
|---|---|
| transcription factor complex | |
| nucleus |
| GO Biological Process | multicellular organismal development |
|---|---|
| cell maturation | |
| cell differentiation | |
| angiogenesis | |
| lung development | |
| hemopoiesis | |
| embryonic placenta development | |
| erythrocyte differentiation | |
| blood vessel remodeling | |
| regulation of heart rate | |
| visual perception | |
| mitochondrion organization | |
| signal transduction | |
| regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter in response to oxidative stress | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| norepinephrine metabolic process | |
| response to oxidative stress | |
| response to hypoxia | |
| surfactant homeostasis |
| Ariadne Ontology | PAS domain |
|---|
| Group | PAS domain |
|---|---|
| transcription regulator activity | |
| multicellular organismal development | |
| cell maturation | |
| cell differentiation | |
| angiogenesis | |
| lung development | |
| hemopoiesis | |
| embryonic placenta development | |
| erythrocyte differentiation | |
| blood vessel remodeling | |
| regulation of heart rate | |
| visual perception | |
| mitochondrion organization | |
| signal transduction | |
| regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter in response to oxidative stress | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| norepinephrine metabolic process | |
| response to oxidative stress | |
| response to hypoxia | |
| surfactant homeostasis | |
| signal transducer activity | |
| transcription factor activity | |
| transcription factor binding | |
| DNA binding | |
| histone acetyltransferase binding | |
| protein heterodimerization activity | |
| transcription coactivator activity | |
| sequence-specific DNA binding | |
| RNA polymerase II transcription factor activity, enhancer binding | |
| specific RNA polymerase II transcription factor activity | |
| cytoplasm | |
| transcription factor complex | |
| nucleus |
| MedScan ID | 2034 |
|---|
| Hugo ID | 3374 |
|---|
| Human chromosome position | 2p21-p16 |
|---|
| LocusLink ID | 2034 |
|---|---|
| 13819 | |
| 29452 |
| Alias | HLF |
|---|---|
| MOP2 | |
| ECYT4 | |
| HIF2A | |
| PASD2 | |
| bHLHe73 | |
| endothelial PAS domain-containing protein 1 | |
| EPAS-1 | |
| HIF2-alpha | |
| HIF-2-alpha | |
| HIF-1alpha-like factor | |
| HIF-1-alpha-like factor | |
| member of PAS protein 2 | |
| PAS domain-containing protein 2 | |
| hypoxia-inducible factor 2 alpha | |
| hypoxia-inducible factor 2-alpha | |
| basic-helix-loop-helix-PAS protein MOP2 | |
| class E basic helix-loop-helix protein 73 | |
| HRF | |
| HIF-2alpha | |
| mHLF | |
| Hif like protein | |
| HIF-related factor | |
| HIF1alpha-like factor | |
| HIF1 alpha-like factor | |
| HLF (HIF1alpha-like factor) | |
| hypoxia inducible transcription factor 2alpha | |
| HIF2 alpha | |
| HIF-2 alpha | |
| hypoxia inducible factor 2a | |
| hypoxia inducible factor 2, alpha subunit | |
| Endothelial PAS domain protein 1 | |
| Endothelial PAS domain protein I | |
| Epas I | |
| Epas1 | |
| Hif like | |
| HLF protein | |
| Member of PAS protein II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603349 |
|---|---|
| 611783 |
| Mouse chromosome position | 17 |
|---|
| GO ID | 0003677 |
|---|---|
| 0003705 | |
| 0035035 | |
| 0046982 | |
| 0043565 | |
| 0004871 | |
| 0003704 | |
| 0003713 | |
| 0008134 | |
| 0001525 | |
| 0001974 | |
| 0030154 | |
| 0048469 | |
| 0001892 | |
| 0030218 | |
| 0030097 | |
| 0030324 | |
| 0007005 | |
| 0007275 | |
| 0042415 | |
| 0045944 | |
| 0002027 | |
| 0043619 | |
| 0006355 | |
| 0001666 | |
| 0006979 | |
| 0007165 | |
| 0043129 | |
| 0006366 | |
| 0007601 | |
| 0005737 | |
| 0005634 | |
| 0005667 | |
| 0003700 | |
| 0030528 | |
| 0045449 | |
| 0006350 |
| Rat chromosome position | 6q12 |
|---|
| Swiss-Prot Accession | B3KW07 |
|---|---|
| Q99814 | |
| Q53SM6 | |
| P97481 | |
| Q6PEU2 | |
| Q9JHS1 | |
| O08787 | |
| O55046 | |
| Q86VA2 | |
| Q99630 |
| Unigene ID | Hs.468410 |
|---|---|
| Mm.1415 | |
| Rn.55138 |
| KEGG ID | hsa:2034 |
|---|---|
| mmu:13819 | |
| rno:29452 |
| Swiss-Prot ID | EPAS1_RAT |
|---|---|
| EPAS1_MOUSE | |
| EPAS1_HUMAN | |
| B3KW07_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00199803 |
|---|---|
| IPI00312615 | |
| IPI00294084 | |
| IPI00943340 | |
| IPI00890928 | |
| IPI00875174 |
| Homologene ID | 1095 |
|---|
| RGD ID | 68404 |
|---|
| MGI ID | 109169 |
|---|