| URN | urn:agi-llid:2033 |
|---|---|
| Connectivity | 1050 |
| Name | EP300 |
| Description | E1A binding protein p300 |
| Notes | This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq] |
| Pathway | IGF1R -> MEF/MYOD/MYOG signaling |
|---|---|
| ERBB2/3 -> EP300/ETS/ETV/SP1 signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| NGFR -> MEF signaling | |
| VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling | |
| VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling | |
| Notch -> EP300/ASCL signaling | |
| TGFBR -> MEF/MYOD/MYOG signaling | |
| Skeletal Myogenesis Control | |
| hypoxia inducible factor pathway |
| GO Molecular Function | antigen binding |
|---|---|
| transferase activity | |
| transcription activator activity | |
| transcription factor activity | |
| transcription factor binding | |
| protein complex binding | |
| SMAD binding | |
| transcription activator binding | |
| DNA binding | |
| bHLH transcription factor binding | |
| NF-kappaB binding | |
| peroxisome proliferator activated receptor binding | |
| glucocorticoid receptor binding | |
| protein kinase binding | |
| mitogen-activated protein kinase binding | |
| transcription coactivator activity | |
| promoter binding | |
| metal ion binding | |
| zinc ion binding | |
| acetyltransferase activity | |
| lysine N-acetyltransferase activity | |
| histone acetyltransferase activity |
| GO Cellular Component | protein-DNA complex |
|---|---|
| cytoplasm | |
| nucleolus | |
| transcription factor complex | |
| histone acetyltransferase complex | |
| nucleus |
| GO Biological Process | cell cycle |
|---|---|
| interspecies interaction between organisms | |
| digestive tract development | |
| organ morphogenesis | |
| somitogenesis | |
| positive regulation of axon extension | |
| nervous system development | |
| lung development | |
| heart development | |
| liver development | |
| skeletal muscle tissue development | |
| positive regulation of sarcomere organization | |
| positive regulation of collagen biosynthetic process | |
| positive regulation of cell growth | |
| positive regulation of protein secretion | |
| positive regulation of cellular metabolic process | |
| negative regulation of cellular metabolic process | |
| protein kinase B signaling cascade | |
| regulation of transcription | |
| positive regulation of proteolysis | |
| positive regulation of translation | |
| positive regulation of glycoprotein biosynthetic process | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein amino acid phosphorylation | |
| regulation of transcription, DNA-dependent | |
| positive regulation of transcription factor activity | |
| positive regulation of protein import into nucleus, translocation | |
| transcription | |
| histone acetylation | |
| histone H4 acetylation | |
| N-terminal peptidyl-lysine acetylation | |
| protein-DNA complex assembly | |
| cellular response to hydrogen peroxide | |
| apoptosis | |
| response to drug | |
| response to hypoxia | |
| response to organic cyclic substance | |
| response to protein stimulus | |
| response to ethanol | |
| response to hydrogen peroxide | |
| response to calcium ion | |
| response to cobalt ion | |
| response to fatty acid | |
| response to estrogen stimulus | |
| response to glucocorticoid stimulus | |
| response to glucose stimulus | |
| response to retinoic acid | |
| positive regulation of gene expression | |
| regulation of angiotensin metabolic process | |
| positive regulation of cell size | |
| positive regulation of DNA binding |
| Ariadne Ontology | Chromatin remodeling |
|---|---|
| Transcription factors |
| Group | Chromatin remodeling |
|---|---|
| Transcription factors | |
| cell cycle | |
| interspecies interaction between organisms | |
| digestive tract development | |
| organ morphogenesis | |
| somitogenesis | |
| positive regulation of axon extension | |
| nervous system development | |
| lung development | |
| heart development | |
| liver development | |
| skeletal muscle tissue development | |
| positive regulation of sarcomere organization | |
| positive regulation of collagen biosynthetic process | |
| positive regulation of cell growth | |
| positive regulation of protein secretion | |
| positive regulation of cellular metabolic process | |
| negative regulation of cellular metabolic process | |
| protein kinase B signaling cascade | |
| regulation of transcription | |
| positive regulation of proteolysis | |
| positive regulation of translation | |
| positive regulation of glycoprotein biosynthetic process | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein amino acid phosphorylation | |
| regulation of transcription, DNA-dependent | |
| positive regulation of transcription factor activity | |
| positive regulation of protein import into nucleus, translocation | |
| transcription | |
| histone acetylation | |
| histone H4 acetylation | |
| N-terminal peptidyl-lysine acetylation | |
| protein-DNA complex assembly | |
| cellular response to hydrogen peroxide | |
| apoptosis | |
| response to drug | |
| response to hypoxia | |
| response to organic cyclic substance | |
| response to protein stimulus | |
| response to ethanol | |
| response to hydrogen peroxide | |
| response to calcium ion | |
| response to cobalt ion | |
| response to fatty acid | |
| response to estrogen stimulus | |
| response to glucocorticoid stimulus | |
| response to glucose stimulus | |
| response to retinoic acid | |
| positive regulation of gene expression | |
| regulation of angiotensin metabolic process | |
| positive regulation of cell size | |
| positive regulation of DNA binding | |
| antigen binding | |
| transferase activity | |
| transcription activator activity | |
| transcription factor activity | |
| transcription factor binding | |
| protein complex binding | |
| SMAD binding | |
| transcription activator binding | |
| DNA binding | |
| bHLH transcription factor binding | |
| NF-kappaB binding | |
| peroxisome proliferator activated receptor binding | |
| glucocorticoid receptor binding | |
| protein kinase binding | |
| mitogen-activated protein kinase binding | |
| transcription coactivator activity | |
| promoter binding | |
| metal ion binding | |
| zinc ion binding | |
| acetyltransferase activity | |
| lysine N-acetyltransferase activity | |
| histone acetyltransferase activity | |
| protein-DNA complex | |
| cytoplasm | |
| nucleolus | |
| transcription factor complex | |
| histone acetyltransferase complex | |
| nucleus |
| MedScan ID | 2033 |
|---|
| Hugo ID | 3373 |
|---|---|
| 35359 |
| Human chromosome position | 22q13.2 |
|---|
| LocusLink ID | 2033 |
|---|---|
| 328572 | |
| 170915 |
| Alias | p300 |
|---|---|
| KAT3B | |
| RP1-85F18.1 | |
| histone acetyltransferase p300 | |
| p300 HAT | |
| E1A-binding protein, 300kD | |
| E1A-associated protein p300 | |
| A430090G16 | |
| A730011L11 | |
| E1A binding protein p300 | |
| 300 kDa E1A-binding protein | |
| 4930432K09 | |
| 4930432K09Rik | |
| CBP/p300 | |
| e1a binding protein | |
| e1a-binding protein | |
| EP300 | |
| OTTHUMP00000028668 | |
| p300/CBP | |
| P300_HUMAN | |
| transcription adapter p300 | |
| transcription adaptor p300 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602700 |
|---|---|
| 114500 | |
| 180849 |
| Mouse chromosome position | 15 |
|---|
| GO ID | 0003677 |
|---|---|
| 0051059 | |
| 0046332 | |
| 0016407 | |
| 0003823 | |
| 0043425 | |
| 0035259 | |
| 0004402 | |
| 0046872 | |
| 0051019 | |
| 0042975 | |
| 0010843 | |
| 0032403 | |
| 0003713 | |
| 0008134 | |
| 0016740 | |
| 0008270 | |
| 0018076 | |
| 0006915 | |
| 0007049 | |
| 0070301 | |
| 0048565 | |
| 0007507 | |
| 0043967 | |
| 0044419 | |
| 0001889 | |
| 0030324 | |
| 0031324 | |
| 0007399 | |
| 0009887 | |
| 0045773 | |
| 0031325 | |
| 0032967 | |
| 0010628 | |
| 0010560 | |
| 0001934 | |
| 0033160 | |
| 0050714 | |
| 0045862 | |
| 0060298 | |
| 0051091 | |
| 0045944 | |
| 0045727 | |
| 0043491 | |
| 0065004 | |
| 0060177 | |
| 0045449 | |
| 0051592 | |
| 0032025 | |
| 0042493 | |
| 0043627 | |
| 0045471 | |
| 0070542 | |
| 0051384 | |
| 0009749 | |
| 0001666 | |
| 0014070 | |
| 0051789 | |
| 0032526 | |
| 0007519 | |
| 0001756 | |
| 0005737 | |
| 0000123 | |
| 0005730 | |
| 0005634 | |
| 0032993 | |
| 0005667 | |
| 0004468 | |
| 0019901 | |
| 0016563 | |
| 0003700 | |
| 0043388 | |
| 0030307 | |
| 0045793 | |
| 0045893 | |
| 0006355 | |
| 0016573 | |
| 0042542 | |
| 0006350 | |
| 0033613 |
| Rat chromosome position | 7q34 |
|---|
| Swiss-Prot Accession | Q09472 |
|---|---|
| Q7Z6C1 | |
| Q38HM2 | |
| Q8BJ14 | |
| Q3USJ1 | |
| Q5RJS0 | |
| Q91XT0 | |
| B1AKC2 |
| PIR ID | A54277 |
|---|
| Unigene ID | Hs.517517 |
|---|---|
| Hs.655211 | |
| Mm.258397 | |
| Mm.473354 | |
| Rn.12447 | |
| Rn.223072 |
| KEGG ID | hsa:2033 |
|---|---|
| mmu:328572 | |
| rno:170915 |
| EC Number | 2.3.1.48 |
|---|
| Swiss-Prot ID | EP300_HUMAN |
|---|---|
| Q7Z6C1_HUMAN | |
| Q8BJ14_MOUSE |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00020985 |
|---|---|
| IPI00461822 | |
| IPI00909883 | |
| IPI00653882 | |
| IPI00765110 | |
| IPI00515830 |
| Homologene ID | 1094 |
|---|
| RGD ID | 620036 |
|---|
| MGI ID | 1276116 |
|---|