Protein Map3k1

URN	urn:agi-llid:4214
Total Entities	0
Connectivity	632
Name	Map3k1
Description	mitogen activated protein kinase kinase kinase 1
Notes	kinase that has E3 ubiquitin ligase to mediate ubiquitination and degradation of ERK1/2 [RGD]

Ariadne Ontology	MAP3K
	Secreted proteins

GO Molecular Function	protein kinase binding
	mitogen-activated protein kinase binding
	JUN kinase binding
	mitogen-activated protein kinase kinase binding
	nucleotide binding
	ATP binding
	sphingolipid binding
	metal ion binding
	zinc ion binding
	protein kinase activity
	protein serine-threonine kinase activity
	MAP kinase kinase kinase activity
	JUN kinase kinase kinase activity
	JUN kinase kinase activity
	ubiquitin-protein ligase activity

GO Cellular Component	membrane
	cytoplasm
	cytosol
	cytoskeleton

GO Biological Process	positive regulation of viral transcription
	activation of MAPKK activity
	activation of JNKK activity
	positive regulation of JUN kinase activity
	activation of JUN kinase activity
	positive regulation of MAP kinase activity
	MAPK cascade
	JNK cascade
	toll-like receptor signaling pathway
	toll-like receptor 2 signaling pathway
	toll-like receptor 4 signaling pathway
	MyD88-dependent toll-like receptor signaling pathway
	toll-like receptor 1 signaling pathway
	Toll signaling pathway
	transforming growth factor beta receptor signaling pathway
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of actin filament bundle assembly
	positive regulation of actin filament polymerization
	positive regulation of apoptotic process
	regulation of cell migration
	protein phosphorylation
	peptidyl-serine phosphorylation
	protein autophosphorylation
	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
	protein polyubiquitination
	cellular response to mechanical stimulus
	apoptotic mitochondrial changes
	innate immune response
	response to osmotic stress
	wound healing
	camera-type eye development
	protein oligomerization

Pathway	FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling
	PDGFR -> AP-1/MYC signaling
	VEGFR -> AP-1/CREB/MYC signaling
	HGFR -> AP-1/CREB/MYC signaling
	AngiopoietinR -> AP-1 signaling
	ErythropoietinR -> AP-1/CREB/MYC signaling
	ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling
	EGFR -> AP-1/CREB/ELK-SRF/MYC signaling
	EGFR -> NCOR2 signaling
	EctodysplasinR -> AP-1 signaling
	TNFRSF6 -> HSF1 signaling
	NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling
	TNFRSF5/6 -> RB1/E2F signaling
	TNFR -> CREB/ELK-SRF signaling
	NGFR -> MEF signaling
	TNFRSF6 -> DDIT3 signaling
	TNFR -> AP-1/ATF/TP53 signaling
	TNFRSF1A -> AP-1/ATF/TP53 signaling
	TNFRSF1A -> CREB/ELK-SRF signaling
	FrizzledR -> JUN/PAX2 signaling
	Notch -> TCF3 signaling
	T-cell receptor -> ATF/CREB signaling
	IL1R -> STAT3 signaling
	IL1R -> NF-kB signaling
	AGER -> CREB/SP1 signaling
	EGFR -> AP-1/ATF2 signaling
	EGFR/ERBB2 -> TP53 signaling
	EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling
	KIT -> MITF signaling
	VEGFR -> NFATC signaling
	VEGFR -> ATF/CREB/ELK-SRF signaling
	IGF1R -> MEF/MYOD/MYOG signaling
	GDNF -> HSF1 signaling
	NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling
	ICAM1 -> AP-1/CREB/ELK-SRF signaling
	FibronectinR -> NF-kB signaling
	FibronectinR -> AP-1/ELK-SRF/SREBF signaling
	ThrombopoietinR -> SPI1 signaling
	EDG2 -> ELK-SRF signaling
	CholinergicRm -> CREB/ELK-SRF signaling
	CannabinoidR -> AP-1/EGR signaling
	DopamineR2 -> AP-1/CREB/ELK-SRF signaling
	SerotoninR1 -> FOS signaling
	PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling
	VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling
	PTAFR -> NF-kB signaling
	VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling
	GNRHR -> ELK-SRF signaling
	GRM1/5 -> CREB signaling
	EDG3/5 -> AP-1/ELK-SRF signaling
	EndothelinRb -> AP-1/CREB/ELK-SRF signaling
	VIPR -> CREB/CEBP signaling
	EndothelinRa -> AP-1/CREB signaling
	VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling
	VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling
	ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling
	Clozapine-Induced Granulocytopenia
	WNT7A Expression Targets
	WNT1 Expression Targets
	WNT4 Expression Targets
	WNT3A Expression Targets
	FASLG Expression Targets
	NGF/FOXO/MYCN/ELK-SRF Expression Targets
	BDNF Expression Targets
	NTF3 Expression Targets
	NTF4 Expression Targets
	CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets
	TNFSF13 Expression Targets
	TNFSF13B Expression Targets
	EDA Expression Targets
	TNFSF10 Expression Targets
	LTA Expression Targets
	TNFSF14 Expression Targets
	TNF/CREB Expression Targets
	TNF/TP53/ATF Expression Targets
	TNF/ELK-SRF Expression Targets
	NGF/AP-1/TP53/MYC Expression Targets
	NGF/CREB/CEBPB/MEF2A Expression Targets
	NGF/SMAD3/NF-kB Expression Targets
	CD40LG/ATF2/AP-1/TP53/E2F Expression Targets
	ICAM1 Expression Targets
	Fibronectin Expression Targets
	Thrombopoietin/SPI1 Expression Targets
	Dopamine/Gi Expression Targets
	Dronabinol/Anandamide Expression Targets
	GNRH2 Expression Targets
	S100A Expression Targets
	S100B Expression Targets
	S100P Expression Target
	HMGB1 Expression Targets
	TTR Expression Targets
	Acetylcholine Expression Targets
	AREG/AP-1 Expression Targets
	AREG/NFATC Expression Target
	BTC/NFATC Expression Targets
	EGF/TP53 Expression Targets
	EREG/AP-1/ATF Expression Targets
	HBEGF/AP-1/ATF Expression Targets
	HBEGF/MEF/MYOD Expression Target
	HBEGF/TP53 Expression Targets
	NRG1/AP-1/ATF Expression Targets
	NRG1/MEF/MYOD Expression Targets
	NRG1/TP53 Expression Target
	TGFA/MEF/MYOD/NFATC Expression Targets
	TGFA/TP53 Expression Targets
	VEGFA/NFATC Expression Targets
	VEGFA/ATF/CREB/ELK-SRF Expression Targets
	VEGFC/ATF Expression Target
	GDNF/HSF1 Expression Targets
	IGF2/MEF/MYOD Expression Targets
	CTGF/AP-1/CREB/MYC Expression Targets
	CTGF/NCOR2 Expression Target
	Erythropoietin/AP-1/MYC/CREB Expression Targets
	FLT3LG/AP-1/CREB/CREBBP Expression Targets
	GAS6/AP-1/CREB Expression Targets
	PGF/AP-1/CREB/CREBBP/MYC Expression Targets
	Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets
	AREG/CREB/CREBBP Expression Targets
	AREG/NCOR2 Expression Targets
	EGF/NCOR2 Expression Target
	EREG/CREB Expression Target
	HBEGF/CREB/MYC Expression Targets
	NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
	TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets
	FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets
	FGF1/NCOR2 Expression Target
	FGF2/NCOR2 Expression Targets
	FGF4/AP-1/MYC Expression Targets
	FGF7/AP-1/CREB/CREBBP/MYC Expression Targets
	FGF8/AP-1/CREB/MYC Expression Targets
	FGF9/AP-1/CREB/MYC Expression Targets
	FGF10/AP-1/CREB/CREBBP/MYC Expression Targets
	FGF18/AP-1/CREB Expression Targets
	FGF23/NCOR2 Expression Targets
	CSF1/AP-1/CREB/CREBBP/MYC Expression Targets
	PDGFB/AP-1/CREB/MYC Expression Target
	PDGFC/CREB Expression Target
	PDGFD/AP-1 Expression Targets
	VEGFA/NCOR2 Expression Target
	ANGPT1/CREB/CREBBP Expression Targets
	ANGPT2/AP-1/CREBBP/MYC Expression Targets
	FIGF/AP-1 Expression Target
	FIGF/NCOR2 Expression Target
	F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
	PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
	Glutamate/Gq Expression Targets
	AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
	AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets
	GNRH1 Expression Targets
	PAF/Gq -> NF-kB Expression Targets
	S1P Expression Targets
	VIP Expression Targets
	AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
	AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets
	EDN1 Expression Targets
	EDN3 Expression Targets
	ADCYAP1 Expression Targets
	IL16/ATF/CREB/CREBBP Expression Target
	CD8/ATF/CREB/CREBBP Expression Targets
	CD80/ATF/CREB/CREBBP Expression Targets
	CD86/ATF/CREB/CREBBP Expression Targets
	CD72/CREB/CREBBP Expression Targets
	PDCD1/ATF/CREB/CREBBP Expression Targets
	TCR/CREB/CREBBP/ATF Expression Targets
	FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
	IL1A Expression Targets
	IL1B/PGE2 Expression Targets
	NOTCH Expression Targets
	WNT5A Expression Targets
	EGF/AP-1/ATF Expression Targets
	EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets
	EGF/MEF/MYOD/NFATC Expression Targets
	HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets
	IGF1/MEF/MYOD/MYOG Expression Targets
	Insulin/MEF/MYOD Expression Targets
	KITLG/AP-1/CREB/CREBBP/MYC Expression Targets
	LPA Expression Targets
	PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets
	PDGF/AP-1/CREB/CREBBP/MYC Expression Targets
	TGFA/AP-1/ATF Expression Targets
	TNF/AP-1 Expression Targets
	VEGFA/AP-1/CREBBP/MYC Expression Targets
	IL1B Expression Targets
	BTC/AP-1/ATF/CREB Expression Targets
	c-Jun N-terminal kinases MAPK signaling pathway
	c-Jun N-terminal kinases MAPK signaling pathway

Group	MAP3K
	positive regulation of viral transcription
	activation of MAPKK activity
	activation of JNKK activity
	positive regulation of JUN kinase activity
	activation of JUN kinase activity
	positive regulation of MAP kinase activity
	MAPK cascade
	JNK cascade
	toll-like receptor signaling pathway
	toll-like receptor 2 signaling pathway
	toll-like receptor 4 signaling pathway
	MyD88-dependent toll-like receptor signaling pathway
	toll-like receptor 1 signaling pathway
	Toll signaling pathway
	transforming growth factor beta receptor signaling pathway
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of actin filament bundle assembly
	positive regulation of actin filament polymerization
	positive regulation of apoptotic process
	regulation of cell migration
	protein phosphorylation
	peptidyl-serine phosphorylation
	protein autophosphorylation
	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
	protein polyubiquitination
	cellular response to mechanical stimulus
	apoptotic mitochondrial changes
	innate immune response
	response to osmotic stress
	wound healing
	camera-type eye development
	protein oligomerization
	protein kinase binding
	mitogen-activated protein kinase binding
	JUN kinase binding
	mitogen-activated protein kinase kinase binding
	nucleotide binding
	ATP binding
	sphingolipid binding
	metal ion binding
	zinc ion binding
	protein kinase activity
	protein serine-threonine kinase activity
	MAP kinase kinase kinase activity
	JUN kinase kinase kinase activity
	JUN kinase kinase activity
	ubiquitin-protein ligase activity
	membrane
	cytoplasm
	cytosol
	cytoskeleton
	Secreted proteins

Source	Curated
	ResNet
	GO component
	RGD modified

MedScan ID	4214

Hugo ID	6848

Human chromosome position	5q11.2

GenBank ID	NC_000005
	NM_005921
	NP_005912
	NG_031884
	NC_018916
	AC_000137
	AC008937
	U29671
	AAB05828
	AA602425
	AF042838
	AAC97073
	AK307828
	BU194120
	BX537527
	DA889202
	Q13233
	NC_000079
	NM_011945
	NP_036075
	AC_000035
	AC118704
	CH466568
	EDL18419
	EDL18420
	AB014614
	BAA85878
	AF117340
	AAD25049
	AK142245
	L13103
	AAA97500
	U23470
	AAA85038
	P53349
	BC172631
	AAI72631
	NC_005101
	NM_053887
	NP_446339
	AC_000070
	AC111653
	CH473955
	EDM10340
	EDM10341
	EDM10342
	JQ013733
	AFD32168
	U48596
	AAC52596
	Q62925
	NT_006713
	NW_922607
	NW_001838934
	AC_000048
	NT_039590
	NW_001030537
	NW_001084795
	NW_047620
	XM_001074670
	XP_001074670
	XP_042066
	AI317205
	XM_042066
	1002604
	2815888
	8488988
	XM_001128827
	XP_001128827
	1143820
	19860665
	293730
	4583380
	6141559
	1354137
	2499638
	NC_007318
	NW_001493936
	XM_602275
	XP_602275
	NC_007123
	NW_001510849
	XM_688224
	XP_693316
	148887396
	148686472
	148686473
	149059333
	149059334
	149059335
	125832195
	126003529
	564899
	Dr.87896
	dre:564899

LocusLink ID	4214
	26401
	116667
	17269
	523962
	564899

Alias	MEKK
	MEKK1
	SRXY6
	MEKK 1
	MAPKKK1
	mitogen-activated protein kinase kinase kinase 1
	MEK kinase 1
	MAP/ERK kinase kinase 1
	MAPK/ERK kinase kinase 1
	mitogen activated protein kinase kinase kinase 1
	MEK kinase
	OTTMUSP00000021865
	OTTHUMP00000065818
	mitogen-activated protein kinase kinase kinase I
	MAP kinase kinase kinase 1
	MAPKKK I
	MAPK/ERK kinase kinase I
	Map3k1
	Map3k I
	MAP/ERK kinase kinase I
	MEK kinase I
	MEKK I
	MAPK/ ERK kinase kinase I
	MAPK/ ERK kinase kinase 1
	LOC564899
	chromosome
	scaffold
	similar to hCG40615

Organism	Homo sapiens
	Mus musculus
	Rattus norvegicus
	Bos taurus
	Danio rerio

OMIM ID	600982
	613762
	OMIM:600982

Unigene ID	Hs.653654
	Mm.15918
	Rn.11081
	Hs.657756
	Hs.508461
	Hs.170610
	Hs.634810
	Bt.65484
	Dr.87896
	Mm.446367

KEGG ID	hsa:4214
	mmu:26401
	rno:116667

Swiss-Prot Accession	Q13233
	F8VQ72
	P53349
	Q62925

EC Number	2.7.11.25
	2.7.1.-

GO ID	0005524
	0008432
	0008545
	0004706
	0004709
	0051019
	0031434
	0004672
	0019901
	0046625
	0004842
	0008270
	0002755
	0008063
	0008637
	0043010
	0071260
	0045087
	0032232
	0018105
	0030838
	0043065
	0050434
	0046777
	0051259
	0006468
	0000209
	0042787
	0030334
	0006970
	0034130
	0034134
	0034142
	0002224
	0007179
	0042060
	0005856
	0005829
	0046872
	0000166
	0007254
	0000165
	0007256
	0007257
	0000186
	0043507
	0043406
	0045944
	0005737
	0016020
	0004674
	0004710
	0000287
	0016740
	0007249
	0010552
	0005624
	0016301
	0042802
	0005575
	0005515
	0008372
	0001747
	0016567
	0000151

PIR ID	T10757
	G01887

Swiss-Prot ID	M3K1_RAT
	M3K1_HUMAN

Cell Localization	Membrane
	Cytoplasm

IPI ID	IPI00210195
	IPI00855985
	IPI00130375
	IPI00677379

Mouse chromosome position	13 60.0 cM

Rat chromosome position	2q14

Homologene ID	8056

MGI ID	1346872
	104845

RGD ID	620966

MedLine Reference	11784851
	9808624
	12941696
	15001576
	15882989
	12011049
	12049732
	15037605
	15164763
	16006144
	8643568
	10611349
	10805784
	11746500
	11756439
	11782455
	11815602
	11903060
	11971970
	11971971
	12048245
	12079429
	12185592
	12228228
	12456688
	12584189
	12600818
	12763138
	12878610
	14500727
	14612408
	14743216
	15205333
	15299005
	16044153
	16046415
	16286467
	16434970
	16636664
	16714289
	16760432
	8597633
	9008162
	9689078
	9836645
	10349636
	10465784
	10523642
	10852963
	11042159
	11076861
	11217851
	11891332
	12122119
	12458213
	12466851
	12493778
	12839996
	14586403
	14967141
	15358865
	15558021
	15601830
	15607429
	15795331
	16141072
	16141073
	16491099
	16557301
	16568086
	16761309
	16887003
	17101801
	17143273
	4035594
	4724491
	4865553
	5630254
	6740513
	6883178
	7618106
	8385802
	8621675
	8637721
	9427625
	9924790
	16427076
	16344560
	17301822
	17397260
	16081685
	9078260

Primary Cell Localization	Cytoplasm

Homo sapiens Chromosome position	5q11.2

Microarray ID	103020_s_at
	103021_r_at
	103022_at
	243030_at
	1424850_at

FunctionalClass	ATP binding
	MAP kinase kinase kinase
	magnesium ion binding
	nucleotide binding
	protein binding
	protein serine/threonine kinase
	transferase
	zinc ion binding
	kinase
	metal ion binding
	protein kinase
	ubiquitin-protein ligase
	identical protein binding
	JUN kinase kinase

Mus musculus Chromosome position	13 60.0 cM

KEGG pathway	GnRH signaling pathway
	MAPK signaling pathway

Rattus norvegicus Chromosome position	2q14

Bos taurus Chromosome position	20